BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Medicine by Design - ECPv6.15.18//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-ORIGINAL-URL:https://mbd.ccrm.ca X-WR-CALDESC:Events for Medicine by Design REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/Toronto BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20180311T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20181104T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20190310T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20191103T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20200308T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20201101T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20210314T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20211107T060000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=America/Toronto:20200616T120000 DTEND;TZID=America/Toronto:20200616T130000 DTSTAMP:20260405T225529 CREATED:20191127T180959Z LAST-MODIFIED:20201203T220705Z UID:7551-1592308800-1592312400@mbd.ccrm.ca SUMMARY:Global Speaker Series: Ulrich Steidl\, MD\, PhD - Albert Einstein College of Medicine DESCRIPTION:Medicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Ulrich Steidl\, MD\, PhD\, professor of cell biology and medicine at the Albert Einstein College of Medicine. The title of this talk will be\, “Stem cell heterogeneity and transcription state dynamics in normal and malignant hematopoiesis.” \n  \n \nAbout Ulrich Steidl\nDr. Steidl is the Diane and Arthur B. Belfer Faculty Scholar in Cancer Research\, director of the Stem Cell Isolation and Xenotransplantation Facility\, and a professor of cell biology and of medicine at Albert Einstein College of Medicine\, and associate chair for translational research in oncology at Montefiore Medical Centre. \nThe Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. URL:https://mbd.ccrm.ca/event/global-speaker-series-ulrich-steidl-june-2020/ LOCATION:Online CATEGORIES:Global Speaker Series ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20200527T150000 DTEND;TZID=America/Toronto:20200527T160000 DTSTAMP:20260405T225529 CREATED:20200417T170936Z LAST-MODIFIED:20200519T170735Z UID:8094-1590591600-1590595200@mbd.ccrm.ca SUMMARY:Career Speaker Series - Ali Khademhosseini DESCRIPTION:Featuring University of Toronto alumnus Ali Khademhosseini\, CEO and Founding Director\, Terasaki Institute for Biomedical Innovation\nRegister at this link. \n\n\nAli Khademhosseini is the CEO and Founding Director of the Terasaki Institute for Biomedical Innovation. He is also a Researcher for Amazon Web Services (AWS) Inc. Previously\, he was a Professor of Bioengineering\, Chemical Engineering and Radiology at the University of California-Los Angeles (UCLA). He joined UCLA as the Levi Knight Chair starting Nov. 2017 from Harvard University where he was a Professor at the Harvard Medical School (HMS) and faculty at the Harvard-MIT’s Division of Health Sciences and Technology (HST)\, Brigham and Women’s Hospital (BWH) and as well as associate faculty at the Wyss Institute for Biologically Inspired Engineering. At Harvard University\, he directed the Biomaterials Innovation Research Center (BIRC) a leading initiative in making engineered biomedical materials. He is recognized as a leader in combining micro and nano-engineering approaches with advanced biomaterials for regenerative medicine applications. He is a recipient of the Presidential Early Career Award for Scientists and Engineers\, the highest honor given by the US government for early career investigators. In 2011\, he received the Pioneers of Miniaturization Prize from the Royal Society of Chemistry (RSC) for his contribution to microscale tissue engineering and microfluidics. In 2016\, he received the Sr. Scientist Award of Tissue Engineering and Regenerative Medicine Society -Americas Chapter (TERMIS-AM)\, and in 2017 he received the Clemson Award of the Society for Biomaterials. He is a fellow of the American Institute of Medical and Biological Engineering (AIMBE)\, Biomedical Engineering Society (BMES)\, Royal Society of Chemistry (RSC)\, Biomaterials Science and Engineering (FBSE)\, Materials Research Society (MRS)\, NANOSMAT Society\, and American Association for the Advancement of Science (AAAS). He is also the recipient of the Mustafa Prize ($500\,000 prize) as well as a member of the International Academy of Medical and Biological Engineering\, Royal Society of Canada and Canadian Academy of Engineering. Currently he serves on the editorial board of numerous leading journals as well as an Associate Editor for ACS Nano. He received his Ph.D. in bioengineering from MIT (2005)\, and MASc (2001) and BASc (1999) degrees from University of Toronto both in chemical engineering. \n  \n\nAbout the series\nTo what extent can we plan and design our careers? How much depends on our environment\, the choices we make\, the opportunities that present themselves\, the networks we build\, and the achievements and failures we experience along the way? The Career Speaker Series will feature speakers who earned a graduate degree and have built interesting careers in regenerative medicine. They will speak about the challenges and opportunities of navigating a career in this emerging industry without a road map. These webinars are for graduate students\, post-doctoral fellows and research associates in regenerative medicine-related fields. URL:https://mbd.ccrm.ca/event/career-speaker-series-2/ LOCATION:Online END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20200525T140000 DTEND;TZID=America/Toronto:20200525T150000 DTSTAMP:20260405T225529 CREATED:20200424T164103Z LAST-MODIFIED:20200424T174726Z UID:8195-1590415200-1590418800@mbd.ccrm.ca SUMMARY:Myogenesis Discussion Group - virtual seminar DESCRIPTION:Please contact Louise Moyle at louise.moyle@utoronto.ca to find out how to join the Myogenesis Discussion Group – virtual serminar \nAbout the Myogenesis Discussion Group\nThe study of myology (skeletal\, smooth and cardiac muscle structure\, function and development) has wide-ranging importance in the field of regenerative medicine. Skeletal muscle is the most abundant tissue in the human body and cardiac muscle is required to circulate blood throughout it. Furthermore\, smooth muscle is present in the walls of hollow organs and the vasculature system\, making these tissues critical for normal physiological function. The goal of this discussion group is to explore models of development\, disease and regeneration in muscle tissues\, as well as potential therapeutic approaches. Within this\, we aim to discuss novel techniques to quantitatively measure all aspects of myology and the challenges associated with developing representative models for these complex tissues. URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-virtual-seminar/ LOCATION:Online END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20200513T150000 DTEND;TZID=America/Toronto:20200513T160000 DTSTAMP:20260405T225529 CREATED:20200417T170359Z LAST-MODIFIED:20200506T165434Z UID:8089-1589382000-1589385600@mbd.ccrm.ca SUMMARY:Career Speaker Series - Matthew Hildebrandt DESCRIPTION:Register at this link. \nFeaturing University of Toronto alumnus Matthew Hildebrandt\, PhD\, Product Manager\, STEMCELL Technologies \n \nMatthew Hildebrandt\, PhD\, joined STEMCELL Technologies in 2019 as an Associate Product Manager. STEMCELL Technologies is a global biotechnology company headquartered in Vancouver producing more than 2\,500 specialized media and cell separation products to support life science research. Dr. Hildebrandt’s academic career was focused around fundamental developmental and RNA biology which started with his PhD work in oncology at the University of Alberta in Edmonton and then continued with a post-doctoral fellowship with Dr. James Ellis at The Hospital for Sick Children in the Department of Developmental and Stem Cell Biology. Here he learned the benefits of human pluripotent stem cells as a model system and collaborated with several groups across Toronto to develop a resource of control human induced pluripotent stem cell lines. He now uses his experience in academia to support the development\, commercialization and maintenance of media products that support researchers using pluripotent stem cells. \n\nAbout the series\nTo what extent can we plan and design our careers? How much depends on our environment\, the choices we make\, the opportunities that present themselves\, the networks we build\, and the achievements and failures we experience along the way? The Career Speaker Series will feature speakers who earned a graduate degree and have built interesting careers in regenerative medicine. They will speak about the challenges and opportunities of navigating a career in this emerging industry without a road map. These webinars are for graduate students\, post-doctoral fellows and research associates in regenerative medicine-related fields. \n  URL:https://mbd.ccrm.ca/event/career-speaker-series/ LOCATION:Online END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20200507T130000 DTEND;TZID=America/Toronto:20200507T140000 DTSTAMP:20260405T225529 CREATED:20200417T172133Z LAST-MODIFIED:20200504T143410Z UID:8098-1588856400-1588860000@mbd.ccrm.ca SUMMARY:Introduction to Single Cell and Spatial Technologies webinar DESCRIPTION:In this webinar\, Adriana Suarez from 10x Genomics will discuss the following:\n-Introduction to single cell and spatial technologies (with a focus on 10x Genomics).\n-Overview of experimental workflows for single cell and spatial analyses.\n-Utility of single cell and spatial technologies to advance stem cell biology\, developmental biology and regenerative medicine with examples on heart development\, lung atlas\, immunotherapy\, induced pluripotency and more. \nThis webinar is for investigators\, research/scientific associates\, trainees and lab technicians at the University of Toronto and its affiliated hospitals. Registration is required. The session will be offered via Zoom webinar. \nAbout single cell and spatial technologies\nThe vast complexities of biology require approaches to build a complete picture\, starting from single cells to tissues and beyond. Single cell and spatial technologies enable researchers to resolve highly complex biological systems\, while bringing into focus the details that matter most. \n\nRegistration for this webinar is now full. Thank you for your interest. URL:https://mbd.ccrm.ca/event/introduction-to-single-cell-and-spatial-technologies-webinar/ LOCATION:Online END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20200421T153000 DTEND;TZID=America/Toronto:20200421T163000 DTSTAMP:20260405T225529 CREATED:20200414T153106Z LAST-MODIFIED:20200424T145838Z UID:8079-1587483000-1587486600@mbd.ccrm.ca SUMMARY:Virtual coffee breaks for trainees in the Medicine by Design community DESCRIPTION:You are invited to join other trainees from the Medicine by Design community for sharing\, support and discussion at a virtual coffee break. \nBrew your favourite hot beverage and join the conversation.  The virtual coffee break will be an unstructured discussion that will allow participants to connect socially and professionally. \nEmail info.mbd@utoronto.ca to receive the link to the meeting. URL:https://mbd.ccrm.ca/event/virtual-coffee-breaks-for-trainees-in-the-medicine-by-design-community-april-21/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20200414T153000 DTEND;TZID=America/Toronto:20200414T163000 DTSTAMP:20260405T225529 CREATED:20200414T152704Z LAST-MODIFIED:20200414T152704Z UID:8076-1586878200-1586881800@mbd.ccrm.ca SUMMARY:Virtual coffee breaks for trainees in the Medicine by Design community DESCRIPTION:You are invited to join other trainees from the Medicine by Design community for sharing\, support and discussion at a virtual coffee break. \nBrew your favourite hot beverage and join the conversation.  The virtual coffee break will be an unstructured discussion that will allow participants to connect socially and professionally. \nEmail info.mbd@utoronto.ca to receive the link to the meeting. URL:https://mbd.ccrm.ca/event/virtual-coffee-breaks-for-trainees-in-the-medicine-by-design-community/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20200407T153000 DTEND;TZID=America/Toronto:20200407T163000 DTSTAMP:20260405T225529 CREATED:20200402T212701Z LAST-MODIFIED:20200424T150134Z UID:8047-1586273400-1586277000@mbd.ccrm.ca SUMMARY:Virtual coffee break for trainees DESCRIPTION:You are invited to join other trainees from the Medicine by Design community for sharing\, support and discussion at a virtual coffee break on Tuesday\, April 7\, at 3:30 p.m. to 4:30 p.m. \nBrew your favourite hot beverage and join the conversation. Hosted by Louise Moyle (Glibert lab)\, the virtual coffee break will be an unstructured discussion that will allow participants to connect socially and professionally. The topic of the discussion will be\, “Staying on top of the literature.” \nEmail info.mbd@utoronto.ca to receive the link to the meeting. URL:https://mbd.ccrm.ca/event/virtual-coffee-break-for-trainees-april-7/ LOCATION:Online ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20200331T140000 DTEND;TZID=America/Toronto:20200331T150000 DTSTAMP:20260405T225529 CREATED:20200327T155821Z LAST-MODIFIED:20200424T150323Z UID:8042-1585663200-1585666800@mbd.ccrm.ca SUMMARY:Virtual coffee break for trainees DESCRIPTION:Trainees in the Medicine by Design community are invited to attend virtual coffee breaks. \nVirtual coffee breaks are a chance to share ideas\, interact socially and discuss topics of interest. These unstructured chats are a way to engage with each other and continue scientific discussion\, even when many labs are closed as a result of the COVID-19 pandemic. \nThe chat on March 31 will be hosted by Maria Abou Chakra\, from the Bader lab\, and will be focused on the topic of Coping in Extraordinary Times. \nPlease email info.mbd@utoronto.ca to register to receive the meeting link. URL:https://mbd.ccrm.ca/event/virtual-coffee-break-for-trainees-march-31/ END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20200218T120000 DTEND;TZID=America/Toronto:20200218T130000 DTSTAMP:20260405T225529 CREATED:20191127T175612Z LAST-MODIFIED:20200130T202459Z UID:7543-1582027200-1582030800@mbd.ccrm.ca SUMMARY:Global Speaker Series: Stuart Forbes\, MB\, ChB - University of Edinburgh DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute and the Ontario Institute for Regenerative Medicine\, is pleased to welcome Stuart Forbes\, MB\, ChB\, director of the Centre for Regenerative Medicine and professor of transplantation and regenerative medicine at the University of Edinburgh\, and consultant hepatologist at the Scottish Liver Transplant Unit. He will give a talk titled\, “Developing regenerative therapies for the damaged liver.” \n\nDownload event poster\nThe event will be livestreamed (link will be live shortly before event)\n\n  \nTalk Abstract\nThe normal liver regenerates well after injury but in severe or chronic damage the regeneration capability begins to fail and cellular senescence develops. We have studied human liver injury and regeneration to develop mouse models that develop epithelial senescence and model human disease. This has revealed plasticity between the biliary and hepatocyte population. The epithelial senescence also drives liver pathology such as fibrosis and can be targeted using small molecule approaches. \nBased upon our studies of liver injury and regeneration we have been developing cell therapies for liver disease including macrophage cell therapy for liver cirrhosis which is now in phase 2. \n  \nBiography\nStuart Forbes is Professor of Transplantation and Regenerative Medicine\, at the University of Edinburgh and the Scottish Liver Transplant Unit. His research focuses on how the chronically damaged liver regenerates and how these mechanisms process becomes deranged in liver and bile duct cancer. Prof. Forbes is Director of the MRC Centre for Regenerative Medicine\, University of Edinburgh which houses 230+ scientists and clinicians. He is Director of the UK wide UKRMP Hub for engineering and exploiting the stem cell niche which aims to exploit the biology of stem cell niches for translational benefit. Prof. Forbes is a consultant Hepatologist at the Scottish Liver Transplant Unit\, Royal Infirmary of Edinburgh and has clinical interests in liver failure\, cancer and transplantation and is running phase 1 and 2 trials of macrophage cell therapy for liver cirrhosis. URL:https://mbd.ccrm.ca/event/global-speaker-series-stuart-forbes-february-2020/ LOCATION:Canada CATEGORIES:Global Speaker Series ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20200121T120000 DTEND;TZID=America/Toronto:20200121T130000 DTSTAMP:20260405T225529 CREATED:20191127T174717Z LAST-MODIFIED:20200110T222642Z UID:7536-1579608000-1579611600@mbd.ccrm.ca SUMMARY:Global Speaker Series: Naomi Leonard\, PhD - Princeton University DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute and the Ontario Institute for Regenerative Medicine\, is pleased to welcome Naomi Leonard\, PhD\, Edwin S. Wilsey Professor in the Department of Mechanical and Aerospace Engineering at Princeton University. She will deliver a talk titled “Resilience and the Dynamics of Spreading Processes“. \n\nDownload poster\nLivestream talk (NOTE: Medicine by Design’s YouTube channel will go live just before the talk begins)\n\n  \nTalk Abstract\nSpreading processes impact biological\, social\, and technological systems. To systematically derive testable predictions and the means to manage spreading\, models are needed that predict spreading dynamics in terms of a few parameters. We study a spreading model in which interacting agents can adjust their susceptibility to the spreading process after first exposure. The model is motivated by an investigation of regulation of foraging by desert harvester ants. Using an analytically tractable model that predicts behaviors exhibited in field data\, we show how resilience of colony foraging rates to changing temperature and humidity can be explained by ants modifying their susceptibility to the spread of foraging\, once exposed to outside conditions. To generalize these results\, we propose and analyze a network contagion model with adjustable susceptibility and agent heterogeneity. We show how four dynamic regimes are distinguished by four numbers that depend on network structure and heterogeneity. In the bi-stable regime\, not captured in traditional models\, there can be a rapid cascade after a long period of quiescence. We show further how our results allow for systematic design of control strategies to suppress or promote spreading. \nThis is joint work with Renato Pagliara and (for the ant foraging study) Deborah Gordon. \nBiography\nNaomi Ehrich Leonard is Edwin S. Wilsey Professor of Mechanical and Aerospace Engineering and associated faculty in Applied and Computational Mathematics at Princeton University.  She is affiliated with the Program in Quantitative and Computational Biology and the Princeton Neuroscience Institute.  Naomi is a control theorist whose work involves analysis and design of feedback and interconnection in complex\, dynamical systems.  She uses mathematical models to study mechanisms of collective motion and collective decision-making for multi-agent systems in biology and in engineering.  She has applied her work to animal group at many scales as well as to rule-based improvisational dance.  She led a multidisciplinary ocean sensing project with a month-long deployment of an automated\, adaptive network of underwater robotic vehicles in Monterey Bay\, CA.  She received her BSE in Mechanical Engineering from Princeton University and her PhD in Electrical Engineering from the University of Maryland.  She is a MacArthur Fellow\, and Fellow of the American Academy of Arts and Sciences\, SIAM\, IEEE\, IFAC\, and ASME. \n\nLearn more URL:https://mbd.ccrm.ca/event/global-speaker-series-naomi-leonard-phd-january-2020/ LOCATION:Canada CATEGORIES:Global Speaker Series ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20191203T080000 DTEND;TZID=America/Toronto:20191203T173000 DTSTAMP:20260405T225529 CREATED:20190226T213104Z LAST-MODIFIED:20191210T192127Z UID:6471-1575360000-1575394200@mbd.ccrm.ca SUMMARY:Medicine by Design Symposium DESCRIPTION:REGISTRATION FOR THIS EVENT HAS CLOSED\nThe 4th annual Medicine by Design Symposium will bring together principal investigators and trainees from across the University of Toronto and its affiliated hospitals\, along with members of our Scientific Advisory Board\, to advance our successful research collaborations toward impact. \nInvited Speakers\n \nSessions will include: \n Controlling stem cell fate and tissue formation\n Novel regenerative medicine approaches to disease treatment\n A panel discussion on enabling early-stage translation \n\nModerator: Michael May\, Chief Executive Officer\, CCRM\nPanellists: Dr. Jane Batt\, Respirologist and Scientist\, Keenan Research Centre for Biomedical Science\, St. Michael’s Hospital\, and Associate Professor\, Faculty of Medicine\, U of T; Dawn Bell\, Chief Scientific Officer\, Novartis Canada and Associate\, Creative Destruction Lab; Cynthia Lavoie\, Managing Director\, AllosteRx Capital; and Phil Vanek\, General Manager\, Cell and Gene Therapy Strategy\, GE Healthcare Life Sciences\n\n Overcoming translational barriers \n\nThe symposium will also include an opportunity for trainees in Medicine by Design-funded labs to present their research during a poster session. \n\nRegistration and Poster Abstract Submission\nGeneral Registration\nWe have reached capacity. Registration for this event has closed. \nTrainee Poster Abstract Submission and Registration\nThe deadline to submit poster abstracts was Oct. 9\, 2019. We are no longer accepting abstracts. \n\nAgenda\n\n Download agenda URL:https://mbd.ccrm.ca/event/symposium-2019/ LOCATION:MaRS Auditorium\, 101 College Street\, Toronto\, Ontario\, M5G 1L7\, Canada CATEGORIES:Symposium ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20191119T120000 DTEND;TZID=America/Toronto:20191119T130000 DTSTAMP:20260405T225529 CREATED:20181210T172653Z LAST-MODIFIED:20191126T154104Z UID:6168-1574164800-1574168400@mbd.ccrm.ca SUMMARY:Global Speaker Series: James Wells\, PhD - Cincinnati Children's Hospital Medical Centre DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome James Wells\, PhD\, director for research\, Division of Endocrinology\, and chief scientific officer\, Center for Stem Cell and Organoid Medicine (CuSTOM) at the Cincinnati Children’s Hospital Medical Centre\, and a professor in the Department of Pediatrics at the University of Cincinnati. He will give a talk titled\, “Using human pluripotent stem cells to study development\, diabetes and digestive disease.” \n\n Download event poster\n This event will be livestreamed (link will be live shortly before event)\n\nBiography\nDr. Wells is an endowed professor of Pediatrics at the Cincinnati Children’s Hospital Medical Center. He is in the Division of Developmental Biology\, is the Director for Basic Research in the Division of Endocrinology and was appointed Chief Scientific Officer of the Center for Stem Cell and Organoid Medicine. \nDr. Wells’ research focuses on the processes by which gastrointestinal and endocrine organs form in the developing embryo and how they maintain systemic metabolic homeostasis postnatally. This work in developmental biology has provided the basis for the efforts to generate human cells and tissues from pluripotent stem cells. His lab pioneered approaches to generate gastrointestinal (GI) tissue organoids of the stomach\, intestine\, and colon from human pluripotent stem cells. Human organoids and mouse models are being used in the lab to study endocrine control of digestion and metabolism\, congenital defects of the digestive tract\, and enteric pathogens. In addition\, Dr. Wells and his colleagues are using organoids as a basis for tissue engineering efforts to generate functional tissues for transplantation. \n Learn more about James Wells URL:https://mbd.ccrm.ca/event/global-speaker-series-james-wells-november-2019/ LOCATION:Canada CATEGORIES:Global Speaker Series ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20191106T083000 DTEND;TZID=America/Toronto:20191108T160000 DTSTAMP:20260405T225529 CREATED:20190628T180008Z LAST-MODIFIED:20191125T194315Z UID:6739-1573029000-1573228800@mbd.ccrm.ca SUMMARY:ISSCR International Symposium: From Stem Cell Biology to New Therapies DESCRIPTION:As our understanding of stem cell biology surges forward\, new and exciting investigational therapies are rapidly advancing towards and through clinical trials. From November 6-8\, 2019\, From Stem Cell Biology to New Therapies will highlight the most current and promising clinical applications of stem cell therapies. The program features world-renowned leaders in translational research from academia and industry\, and will include an interactive panel that will discuss the regulatory challenges of translational stem cell research. \n\nRegister and submit poster abstracts URL:https://mbd.ccrm.ca/event/isscr-international-symposium-toronto-november-2019/ LOCATION:Metro Toronto Convention Centre\, 255 Front Street West\, Toronto\, Ontario\, M5V 2W6\, Canada CATEGORIES:External Events END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20191104T131500 DTEND;TZID=America/Toronto:20191104T141500 DTSTAMP:20260405T225529 CREATED:20190226T211610Z LAST-MODIFIED:20191125T194315Z UID:6464-1572873300-1572876900@mbd.ccrm.ca SUMMARY:Synthetic Biology Discussion Group DESCRIPTION:Dr. Michael Aregger\, a post-doctoral fellow in the Moffat lab\, will give a talk titled “Global mapping of human genetic interactions using CRISPR-Cas screens.” \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups\n\nTalk Abstract\nCRISPR-Cas technology has revolutionized genome editing and has facilitated the elucidation of gene function and therapeutic targets for diseases such as cancer. During my PostDoc in Jason Moffat’s lab I have developed and applied genome-wide CRISPR-Cas9 screens for the identification of fitness genes in human cells. More recently\, I have applied CRISPR screens for the global mapping of genetic interactions for genes functioning in cellular metabolism\, whose rewiring is a cancer hallmark and a major focus in the development of novel therapeutic agents. Our data reveals extensive cross talk between metabolic pathways and uncovered the functional role of previously uncharacterized genes. Finally\, we have developed a novel CRISPR-Cas screening platform that allows for highly specific combinatorial targeting of multiple genes\, genetic elements or genomic sites. We have applied this platform to reveal extensive genetic interactions between paralogous genes and uncovered previously masked phenotypes due to genetic redundancy. \nCollectively\, in this seminar I will present the CRISPR-based screening strategies we have generated to map genetic interaction networks in human cells that can be leveraged to study the wiring of cellular states\, determine novel gene functions and serve as a source for the rational design of combinatorial anti-cancer therapeutic strategies. URL:https://mbd.ccrm.ca/event/synbio-discussion-group-2019-november/ LOCATION:Canada CATEGORIES:Discussion Groups ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20191104T083000 DTEND;TZID=America/Toronto:20191106T153000 DTSTAMP:20260405T225529 CREATED:20190628T180815Z LAST-MODIFIED:20191125T194315Z UID:6742-1572856200-1573054200@mbd.ccrm.ca SUMMARY:Till & McCulloch Meetings DESCRIPTION:The Till & McCulloch Meetings are Canada’s stem cell research conference. As the only conference of its kind in Canada\, the Till & McCulloch Meetings provide an unparalleled opportunity for you or your organization to meet and network with Canada’s leading stem cell scientists\, clinicians\, bioengineers and ethicists\, as well as representatives from industry\, government\, health and NGO sectors from around the world. \nThe 2019 Till & McCulloch Meetings (TMM2019) will take place in Montréal\, Québec\, November 4-6\, 2019. \nOnline Registration opens early April\, 2019 \nEarly Bird Registration closes on August 14\, 2019 \nOnline Registration closes on October 9\, 2019 \nThe 2019 Till & McCulloch Meetings are hosted by the Stem Cell Network and CCRM.Hotel Bonaventure Montréal URL:https://mbd.ccrm.ca/event/tmm-2019/ LOCATION:Hotel Bonaventure Montréal\, 900 Rue de la Gauchetière Ouest\, Montréal\, Québec\, H5A 1E4\, Canada CATEGORIES:External Events END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20191022T120000 DTEND;TZID=America/Toronto:20191022T130000 DTSTAMP:20260405T225529 CREATED:20181210T172224Z LAST-MODIFIED:20200424T173347Z UID:6166-1571745600-1571749200@mbd.ccrm.ca SUMMARY:Global Speaker Series: Karen Christman\, PhD - University of California\, San Diego DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Karen Christman\, PhD\, a professor of bioengineering at the Sanford Consortium for Regenerative Medicine at the University of California\, San Diego. She will give a talk titled\, “Decellularized extracellular matrix based hydrogels for regenerative engineering.” \n Download event poster\n This event will be livestreamed (link will be live shortly before event) \nTalk Abstract\nThe extracellular matrix (ECM) is nature’s scaffold\, and in recent years\, researchers have isolated these scaffolds for tissue engineering applications by removing the cellular components\, a process called decellularization. These scaffolds are known to promote cell influx\, regeneration\, and healing in a variety of tissues\, and their degradation products have angiogenic\, chemoattractant\, and antimicrobial properties\, as well as promote cell proliferation. By removal of the cellular antigens\, these scaffolds are considered biocompatible\, and xenogeneic sources can be used. While these scaffolds retain the native ECM structure\, they are not amenable to minimally invasive\, injectable procedures.  We have developed a variety of injectable ECM derived hydrogels that self-assemble to form porous\, nanofibrous scaffolds once injected in vivo or brought to physiological conditions in vitro.  These ECM based scaffolds have been shown to increase tissue specific differentiation and maturation of a variety of progenitor and stem cells in vitro\, and are showing promise in vivo in several tissues including the myocardium and skeletal muscle.  This talk will cover the recent progress with these materials including the first clinical trial in myocardial infarction patients. \nBiography\nDr. Christman is a Professor in the Department of Bioengineering in the Jacobs School of Engineering at UC San Diego.  She received her B.S. in Biomedical Engineering from Northwestern University in 2000 and her Ph.D. from the University of California San Francisco and Berkeley Joint Bioengineering Graduate Group in 2003\, where she examined in situ approaches to myocardial tissue engineering.  She was also a NIH postdoctoral fellow at the University of California\, Los Angeles in the fields of polymer chemistry and nanotechnology.  Dr. Christman joined the Department of Bioengineering in 2007 and is a member of the Institute of Engineering in Medicine at the University of California\, San Diego.  Her lab\, which is housed in the Sanford Consortium for Regenerative Medicine\, focuses on developing novel biomaterials for tissue engineering and regenerative medicine applications\, and has a strong translational focus with the main goal of developing minimally invasive therapies for cardiovascular disease and women’s health.  Dr. Christman is a fellow of the American Heart Association and the American Institute for Medical and Biological Engineering\, and has received several awards including the NIH Director’s New Innovator and Transformative Research Awards\, the Wallace H. Coulter Foundation Early Career Translational Research Award\, the American Heart Association Western States Innovative Sciences Award\, and the Tissue Engineering and Regenerative Medicine Society’s Young Investigator and Senior Scientist Awards.  Dr. Christman is also co-founder of Ventrix\, Inc.\, which has completed a Phase I clinical trial and is currently planning a Phase II trial with the cardiac extracellular matrix hydrogel technology developed in her lab at UC San Diego. \n Learn more about Karen Christman URL:https://mbd.ccrm.ca/event/global-speaker-series-karen-christman-october-2019/ LOCATION:Canada CATEGORIES:Global Speaker Series ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20190923T133000 DTEND;TZID=America/Toronto:20190923T150000 DTSTAMP:20260405T225529 CREATED:20190912T190234Z LAST-MODIFIED:20191125T194315Z UID:6872-1569245400-1569250800@mbd.ccrm.ca SUMMARY:Myogenesis Discussion Group DESCRIPTION:This meeting will feature two talks: \n\nJared Te (Dr. Jane Batt lab): “Enabling skeletal muscle repair and functional recovery following denervation-induced injury using ultrasound mediated gene delivery (UMGD)”\nLouise Moyle (Dr. Penney Gilbert lab): “Breaking the LINC in satellite cells: does disrupted mechanosignalling affect skeletal muscle regeneration?”\n\nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Louise Moyle. \n\nLearn more about Medicine by Design discussion groups URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-2019-september/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Discussion Groups END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20190917T120000 DTEND;TZID=America/Toronto:20190917T130000 DTSTAMP:20260405T225529 CREATED:20181210T171838Z LAST-MODIFIED:20191126T154223Z UID:6164-1568721600-1568725200@mbd.ccrm.ca SUMMARY:Global Speaker Series: Guo-Li Ming\, MD\, PhD - University of Pennsylvania DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Guo-Li Ming\, MD\, PhD\, professor of neuroscience at the Perelman School of Medicine\, University of Pennsylvania. She will give a talk titled\, “Brain-Region-Specific Organoids for Modeling Neurodevelopment and Disease.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\nTalk Abstract\nThree dimensional (3D) organoid cultures from human iPSCs have been recently developed to recapitulate the development and resemble the cytoarchitecture of various organs. Human brain is probably the most complex organ in the human body.  Several proof of principle studies demonstrate that human brain organoids can serve as a unique experimental model to probe the molecular and cellular mechanisms underlying the human brain development and to model neurodevelopmental disorders\, such as microcephaly and autism. We have developed various protocols to produce brain-region specific organoids derived from human iPSCs using a novel miniaturized spinning bioreactor\, including forebrain\, midbrain and hypothalamus organoids.  I will present our recent progress on using these organoids as model systems to study human neurogenesis. \nLearn more about Guo-Li Ming URL:https://mbd.ccrm.ca/event/global-speaker-series-guo-li-ming-september-2019/ LOCATION:Canada CATEGORIES:Global Speaker Series ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20190827T120000 DTEND;TZID=America/Toronto:20190827T130000 DTSTAMP:20260405T225529 CREATED:20190226T210846Z LAST-MODIFIED:20191125T194315Z UID:6460-1566907200-1566910800@mbd.ccrm.ca SUMMARY:Synthetic Biology Discussion Group DESCRIPTION:Dr. Claudio Monetti\, a senior scientist at panCELLa\, will give a talk. \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups URL:https://mbd.ccrm.ca/event/synbio-discussion-group-2019-august/ LOCATION:Canada CATEGORIES:Discussion Groups ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20190826T120000 DTEND;TZID=America/Toronto:20190826T140000 DTSTAMP:20260405T225529 CREATED:20190514T203615Z LAST-MODIFIED:20191125T194315Z UID:6622-1566820800-1566828000@mbd.ccrm.ca SUMMARY:Myogenesis Discussion Group DESCRIPTION:This group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact the group organizers. \n\nLearn more about Medicine by Design discussion groups URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-august-2019/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Discussion Groups ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20190730T120000 DTEND;TZID=America/Toronto:20190730T130000 DTSTAMP:20260405T225529 CREATED:20190226T210558Z LAST-MODIFIED:20191125T194315Z UID:6458-1564488000-1564491600@mbd.ccrm.ca SUMMARY:Synthetic Biology Discussion Group DESCRIPTION:Jenise Chen\, a PhD candidate in the Kelley lab\, will give a talk titled “A multiplexed\, electrochemical interface for cell-free synthetic toehold-mediated gene networks”. \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups\n\nTalk abstract\nThe implementation of colorimetric detection techniques has offered a powerful means of producing rapid qualitative results with easy visual readout. However\, these techniques are usually limited to either a “yes” or “no” answer and have difficulty multiplexing over three targets simultaneously. Electrochemical detection is capable of providing solutions to these limitations. The key advantage of electrochemical assays is the ability for signal amplification\, allowing for trace analyte detection. Recent literature has highlighted the promising avenues of synthetic biology and cell-free gene circuits. This project is the first of its kind to detect cell-free synthetic gene circuits through electrochemical readout. A gold-based electrochemical sensor has been designed to implement five different detection sites for restriction enzyme cutting of surface-immobilized DNA labelled with methylene blue. Restriction enzymes are produced through a cell-free toehold gene circuit and are easily redesigned for disease-specific detection. By coupling electrochemical detection and cell-free toehold gene circuits\, we were able to create a multiplexed assay for applications in antibiotics and antibiotic resistance detection. URL:https://mbd.ccrm.ca/event/synbio-discussion-group-2019-july/ LOCATION:Canada CATEGORIES:Discussion Groups ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20190729T120000 DTEND;TZID=America/Toronto:20190729T140000 DTSTAMP:20260405T225529 CREATED:20190514T203428Z LAST-MODIFIED:20191125T194316Z UID:6620-1564401600-1564408800@mbd.ccrm.ca SUMMARY:Myogenesis Discussion Group DESCRIPTION:This group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact the group organizers. \n\nLearn more about Medicine by Design discussion groups URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-july-2019/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Discussion Groups ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20190723T110000 DTEND;TZID=America/Toronto:20190723T120000 DTSTAMP:20260405T225529 CREATED:20190716T183334Z LAST-MODIFIED:20191125T194316Z UID:6804-1563879600-1563883200@mbd.ccrm.ca SUMMARY:Translational Biology & Engineering Program Research Seminar: Shulamit Levenberg\, PhD\, Technion DESCRIPTION:Professor Shulamit Levenberg\, PhD\, Dean of the Faculty of Biomedical Engineering at Technion-Israel Institute of Technology will give a talk titled “Engineered vascularized tissue constructs.” \n\nLearn more URL:https://mbd.ccrm.ca/event/translational-biology-engineering-program-research-seminar-shulamit-levenberg-phd-technion/ LOCATION:Ted Rogers Centre for Heart Research\, 661 University Avenue\, 14th Floor\, Toronto\, Ontario\, M5G 1M1\, Canada CATEGORIES:Other Events END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20190718T120000 DTEND;TZID=America/Toronto:20190718T130000 DTSTAMP:20260405T225529 CREATED:20190610T150117Z LAST-MODIFIED:20191126T154434Z UID:6713-1563451200-1563454800@mbd.ccrm.ca SUMMARY:Global Speaker Series: Shulamit Levenberg\, PhD — Technion-Israel Institute of Technology DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Shulamit Levenberg\, PhD\, Dean of the Faculty of Biomedical Engineering at Technion-Israel Institute of Technology and the inaugural Medicine by Design Scholar in Residence. The title of her talk is “Vascularization Dynamics in Engineered Tissues.” \n\nDownload event poster\n\nBiography\nProfessor Shulamit Levenberg is the elected Dean of the Biomedical Engineering Department at the Technion. She also serves as the director of the Technion Center for 3D Bioprinting and The Rina & Avner Schneur Center for Diabetes Research. Professor Levenberg earned her PhD at the Weizmann Institute of Science\, where she focused on cell adhesion dynamics and signaling\, and pursued her post-doctoral research in tissue engineering at MIT\, in the lab of Professor Robert Langer. In 2004\, she joined the Technion Faculty of Biomedical Engineering where she conducts interdisciplinary research on stem cells and tissue engineering. She spent a sabbatical year (2011-2012) as a visiting professor at the Wyss Institute for Biology Inspired Engineering at Harvard University and a summer sabbatical (2017) at the University of Western Australia as a winner of the Raine Visiting Professor Award. Professor Levenberg received the Krill Prize for excellence in scientific research\, awarded by the Wolf Foundation\, and was named by Scientific American as a “Research Leader” in tissue engineering\, for her seminal work on vascularization of engineered tissues. She also received the France-Israel Foundation Prize\, the Italian Excellence for Israel Prize\, the Teva Research Prize and the Juludan Prize. In 2018\, she received the Rappaport Prize for Biomedical Sciences. Professor Levenberg has authored more than 100 publications\, and presented her work in over 100 international conferences as an invited or keynote speaker. She is founder and chief scientific officer of two start-up companies in the areas of cultured meat and nanoliter arrays for rapid antimicrobial susceptibility testing.  She is a member of the Israel National Counsel for Bioethics and is actively involved in training young scientists. URL:https://mbd.ccrm.ca/event/global-speaker-series-shulamit-levenberg-july-2019/ LOCATION:Canada CATEGORIES:Global Speaker Series ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20190706T080000 DTEND;TZID=America/Toronto:20190721T170000 DTSTAMP:20260405T225529 CREATED:20190628T182304Z LAST-MODIFIED:20191125T194316Z UID:6748-1562400000-1563728400@mbd.ccrm.ca SUMMARY:Summer by Design DESCRIPTION:How do you move innovative regenerative medicine discoveries out of the lab efficiently and effectively so patients benefit sooner? \nMedicine by Design\, in partnership with CCRM and the Rotman School of Management\, hosts a two-week workshop each summer for high-performing PhD candidates and post-doctoral fellows from around the world to advance their understanding of how to translate and commercialize regenerative medicine research. The workshop takes place in Toronto\, Canada\, where stem cells were first discovered in the 1960s and a leading regenerative medicine ecosystem has developed. \nSummer by Design brings together trainees from selected international regenerative medicine institutes and the University of Toronto and its affiliated hospitals to learn from experts in clinical translation and commercialization\, explore the city’s dynamic life sciences hub\, and make connections with emerging researchers from around the world. URL:https://mbd.ccrm.ca/event/summer-by-design/ CATEGORIES:Workshops ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20190624T120000 DTEND;TZID=America/Toronto:20190624T140000 DTSTAMP:20260405T225529 CREATED:20190514T203259Z LAST-MODIFIED:20191125T194316Z UID:6618-1561377600-1561384800@mbd.ccrm.ca SUMMARY:Myogenesis Discussion Group DESCRIPTION:This group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact the group organizers. \n\nLearn more about Medicine by Design discussion groups URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-2/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Discussion Groups ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20190618T120000 DTEND;TZID=America/Toronto:20190618T130000 DTSTAMP:20260405T225529 CREATED:20190510T164043Z LAST-MODIFIED:20191126T154411Z UID:6590-1560859200-1560862800@mbd.ccrm.ca SUMMARY:Global Speaker Series: Kevin Chalut\, PhD — University of Cambridge DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Kevin Chalut\, PhD\, a Royal Society University Research Fellow\, Cavendish Laboratory\, at the University of Cambridge and principal investigator in the Cambridge Stem Cell Institute. He will give a talk titled\, “Mechanical signalling and cell fate.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\n  \nTalk Abstract\nThe role of mechanical signaling in cell fate choice has been largely overlooked; however\, it plays a significant role in tuning cellular response to signals. My lab is investigating the interplay between biochemical signaling and mechanical signaling in cell fate decisions. I will show first in the mouse embryo that biochemical signaling modulates cytoskeletal contractility to influence spatial positioning and solidify cell fate choice. I will then show that mechanics tunes the response of the cell to biochemical signaling to steer fate choice. This hypothetical feedback loop between mechanics and biochemical signaling likely has significant impact on cellular plasticity both in development and stem cells. I will also present an example demonstrating the functional impact of mechanics on stem cell function. In this example\, we have shown that we can reverse the loss of plasticity associated with ageing by controlling the mechanical microenvironment. Ultimately\, I will advance the hypothesis that mechanical sensing acts as a switch to modulate growth factor signaling to modulate cell fate choice. \n  \nBiography\nKevin Chalut is a biophysicist with a PhD in Physics from Duke University. He is currently a group leader at the Wellcome Trust-Medical Research Council Stem Cell Institute in Cambridge. \nHis work focuses on using the tools and concepts of physics to study cell fate choice in stem cells and developing organisms. His lab primarily investigates how the mechanical microenvironment regulates fate decisions\, and exactly how cells process information during that fate choice. The ultimate goal of his laboratory is to apply their physics-based techniques to understand how organisms develop\, and also how to use stem cells for therapeutic use. URL:https://mbd.ccrm.ca/event/global-speaker-series-kevin-chalut-june-2019/ LOCATION:Medical Sciences Building\, Room 2172\, 1 King's College Circle\, Toronto\, Ontario\, M5S 1A8\, Canada CATEGORIES:Global Speaker Series ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20190603T120000 DTEND;TZID=America/Toronto:20190603T130000 DTSTAMP:20260405T225529 CREATED:20181210T171351Z LAST-MODIFIED:20200429T165518Z UID:6162-1559563200-1559566800@mbd.ccrm.ca SUMMARY:Global Speaker Series: Daniel G. Anderson\, PhD - Massachusetts Institute of Technology DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Daniel G. Anderson\, PhD\, the Samuel A. Goldblith Professor of Applied Biology\, associate professor in the Department of Chemical Engineering and Institute for Medical Engineering and Science\, and a member of the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology. He will give a talk titled\, “Delivery systems for in vivo genome editing and cell therapy.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\nTalk Abstract\nHigh throughput\, combinatorial approaches have revolutionized small molecule drug discovery.  Here we describe our work on the combinatorial development of biomaterials for medical devices ranging from nanoparticulate delivery systems to macroscopic devices.  One focus of our work is on nanoparticulate\, intracellular delivery systems for RNA therapy and gene editing.  Libraries of degradable polymers and lipid-like materials have been synthesized\, formulated and screened for their ability to delivery macromolecular payloads inside of cells.  A number of delivery formulations have been developed with in vivo efficacy\, enabling gene suppression with siRNA\, gene expression with mRNA\, or permanent genetic editing using the CRISPR/Cas9 system.  These formulations show potential therapeutic application for the treatment of disease in both rodent and primate models.  A second focus of our work is on developing biomaterials that can avoid the fibrotic response common to implanted medical devices.  Using combinatorial chemistry\, we have developed new materials capable of avoiding fibrosis and scar tissue formation. These show particular promise as vehicles for the immune-isolation of transplanted cells\, for the treatment of diabetes.  When formulated into microcapsules these materials enable functional\, long-term islet transplantation in immune competent\, diabetic rodents\, as well as normal non-human primates. \nBiography\nLearn more about Daniel G. Anderson URL:https://mbd.ccrm.ca/event/global-speaker-series-daniel-anderson-june-2019/ LOCATION:Medical Sciences Building\, Room 2172\, 1 King's College Circle\, Toronto\, Ontario\, M5S 1A8\, Canada CATEGORIES:Global Speaker Series ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20190528T120000 DTEND;TZID=America/Toronto:20190528T140000 DTSTAMP:20260405T225529 CREATED:20190514T201412Z LAST-MODIFIED:20191125T194316Z UID:6614-1559044800-1559052000@mbd.ccrm.ca SUMMARY:Myogenesis Discussion Group DESCRIPTION:This meeting will feature two speakers \n\nChristine Nguyen (Stewart lab): “Characterizing the electrophysiological properties of 3D bioengineered skeletal muscle”\nBella Xu (Gilbert lab): “An in vitro functional assay to predict in vivo muscle stem cell engraftment outcomes – faster\, cheaper and easier”\n\nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact the group organizers. \n\nLearn more about Medicine by Design discussion groups URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-may-2019/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Discussion Groups ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT END:VCALENDAR