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DTSTART;TZID=America/Toronto:20240312T120000
DTEND;TZID=America/Toronto:20240312T130000
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SUMMARY:Global Speaker Series: Shruti Naik\, PhD - New York University Grossman School of Medicine
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nJoin speaker\, Shruti Naik\, Associate Professor in Pathology\, Medicine and Dermatology and Associate Director of the Colton Center for Autoimmunity at NYU Grossman School of Medicine. \nTalk title: Immune-mediated mechanisms of tissue adaptation and maladaptation. \nREGISTER HERE\nAbout Shruti Naik \n\n  \n  \n  \n  \nDr. Shruti Naik\, Ph.D.\, holds the position of Associate Professor in Pathology\, Medicine and Dermatology and also serves as the Associate Director of the Colton Center for Autoimmunity at NYU Grossman School of Medicine. \nDr. Naik is an international leader in immunology and regenerative medicine. Her research examines how Psoriasis and Inflammatory Bowel Disease\, the most common chronic inflammatory diseases that collectively affect ~5% of the Western population\, profoundly impair organ function. By leveraging cutting-edge technologies to study mechanisms of how immune cells comminate with tissues in health and disease\, Naik seeks to develop curative therapies that halt inflammatory damage and rejuvenate organs at the cellular and molecular level. \nDr. Naik earned her B.S. in Cell and Molecular Biology from the University of Maryland College Park and subsequently obtained her Ph.D. through the University of Pennsylvania-NIH graduate partnership program under the mentorship of Drs. Yasmine Belkaid and Julie Segre. She further honed her expertise as s Damon Runyon Postdoctoral Fellow at the Rockefeller University in New York City. \nIn addition to her outstanding research contributions\, Dr. Naik is a strong advocate for increasing diversity in science. She is also committed to mentoring the next generation of scientists and physicians. Her involvement extends to serving on Scientific Advisory Board of the Keystone Symposium and her role as an Executive Producer of the film Six Degrees from Science. Dr. Naik has received numerous accolades for her groundbreaking research and advocacy including the Regeneron Award for Creative Innovation\, the L’Oréal For Women in Science Award\, the Damon Runyon Dale F. Frey Award for Breakthrough Scientist\, the Blavatnik Award for Young Scientists\, the International Takeda International Innovators in Science Award\, Pew-Stewart Scholar\, NIH Directors Innovator Award DP2\, Packard Fellow\, Burrows Welcome PATH award\, and is a NYSCF Robertson Stem Cell Investigator. \nTalk abstract \nThe epithelial tissues that line our body routinely experience inflammation inducing pathogenic and noxious agents. The mechanisms and consequences of how epithelial tissues\, and in particular their long-lived stem cells\, sense\, respond to\, and remember such encounters are only now beginning to unfold. I discuss the crosstalk between immune cells\, epithelial stem cells\, and c microbes and its importance for epithelial health and repair. Understanding these dynamic interactions may provide unique means of boosting epithelial barrier function and healing by modulating immune and microbial signals perceived by stem cells \nHosted by Medicine by Design\, in partnership with the McEwen Stem Cell Institute.  \n This event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room. \n 
URL:https://mbd.ccrm.ca/event/global-speaker-series-shruti-naik-phd-new-york-university-school-of-medicine/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240207T120000
DTEND;TZID=America/Toronto:20240207T130000
DTSTAMP:20231220T162622Z
CREATED:20231220T162622Z
LAST-MODIFIED:20231220T162622Z
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SUMMARY:Careers Beyond Academia - John Preece and Kori St Cyr
DESCRIPTION:Speakers:\nJohn Preece – Sector Development Officer\, Life Sciences\, City of Toronto\, Economic Development & Culture \nKori St Cyr – Director\, Policy and Government Relations\, Natural Sciences and Engineering Research Council of Canada (NSERC)  \n\nCareers Beyond Academia\n“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. For previous recordings of Careers Beyond Academia see here. \nWho Should Attend?\nAttendees should be research trainees‡ who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \n‡ A research trainee is a graduate student\, post-doc\, research associate and/or technician currently working a Canadian lab. \nLearning Objectives:\n\nHelp trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be\nExpose candidates to careers that they might not have previously considered as typical careers in the life sciences\n\n\n\n\n\n\nDate\nConfirmed Speakers\nLink to Register\n\n\n\n\nFebruary 7\, 2024\nJohn Preece – Sector Development Officer\, Life Sciences\, City of Toronto\, Economic Development & Culture \nKori St Cyr – Director\, Policy and Government Relations\, Natural Sciences and Engineering Research Council of Canada (NSERC)\n\n\n\n\nSign up here!
URL:https://mbd.ccrm.ca/event/careers-beyond-academia-john-preece-and-kori-st-cyr/
CATEGORIES:Career Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240206T120000
DTEND;TZID=America/Toronto:20240206T130000
DTSTAMP:20240131T150148Z
CREATED:20230921T175131Z
LAST-MODIFIED:20240131T150148Z
UID:21193-1707220800-1707224400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Bernard Thébaud\, MD\, PhD – Ottawa Hospital Research Institute
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nJoin speaker Bernard Thébaud\, Senior Scientist\, Regenerative Medicine Program\, Ottawa Hospital Research Institute\, Neonatologist\, Department of Pediatrics\, The Ottawa Hospital and the Children’s Hospital of Eastern Ontario\, Professor\, Department of Pediatrics and Partnership Research Chair\, Regenerative Medicine\, University of Ottawa. \nHosted by Medicine by Design\, in partnership with the McEwen Stem Cell Institute.  \nTalk title: Helping Underdeveloped Lungs with Cells – The HULC trials from Petri dish to Patient  \nREGISTER HERE\nAbout Bernard Thébaud \n\n  \n  \n  \n  \nDr. Bernard Thébaud is a clinician-scientist with a focus on the clinical translation of stem cell-based therapies for lung diseases. He is a senior scientist with the Ottawa Hospital Research Institute and a neonatologist with the Children’s Hospital of Eastern Ontario\, providing care to critically ill newborns. He is also a Professor of Pediatrics at the University of Ottawa.  Dr. Thébaud obtained his MD at the University Louis Pasteur in Strasbourg in France and trained in Pediatrics and Neonatology at the University Paris V\, where he obtained his MSc and PhD before completing a 2-year postdoctoral fellowship at the University of Alberta.  \nDr. Thébaud studies the mechanisms of lung development\, injury and repair to design new treatments for incurable lung diseases. His focus is on answering clinically relevant questions for translation into real-life applications. He is now translating innovative cell and gene therapies from the lab into patients to improve outcomes.  Dr. Thébaud has participated on numerous peer reviews committees and scientific advisory boards at the international\, national and provincial level\, including CIHR and NIH. Dr. Thébaud holds the University of Ottawa Partnership Research Chair in Regenerative Medicine. His research is funded by the Canadian Institutes of Health Research\, the Heart and Stroke Foundation of Canada\, and the Stem Cell Network.  \nTalk abstract \nPreterm birth is a leading cause of infant morbidity and mortality worldwide. Bronchopulmonary dysplasia (BPD)\, the chronic lung disease that follows ventilator and O2 therapy for acute respiratory failure\, is the most common complication of prematurity and accounts for much of the long-term morbidity. BPD lacks effective therapies. Experimental data over the past 15 years have provided some evidence for the potential for cell-based therapies to prevent neonatal lung injury and have led to early phase clinical trials using mesenchymal stromal cells. This presentation will summarize the hazardous path from Petri dish to Patient and acknowledge the current stage of infancy of cell-based therapy. Much more needs to be learned about the biology of these putative repair cells in order to fully harness their therapeutic potential.  \nThis event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room.
URL:https://mbd.ccrm.ca/event/global-speaker-series-bernard-thebaud-md-phd-ottawa-hospital-research-institute/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240123T120000
DTEND;TZID=America/Toronto:20240123T130000
DTSTAMP:20240111T143704Z
CREATED:20230921T175506Z
LAST-MODIFIED:20240111T143704Z
UID:21196-1706011200-1706014800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Ana Andreazza\, PhD - University of Toronto
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nJoin speaker Ana Andreazza\, Professor in the Departments of Pharmacology & Toxicology and Psychiatry at the University of Toronto\, Tier II Canada Research Chair in Molecular Pharmacology of Mood Disorders\, and Thomas C. Zachos Chair in Mitochondrial Research. \nHosted by Medicine by Design\, in partnership with the McEwen Stem Cell Institute.  \nTalk title: Brain\, mitochondria & metabolism: A transdiagnostic dimension \nREGISTER HERE\n  \nAbout Ana Andreazza \n\n  \n  \n  \n  \nAs a Professor at the University of Toronto in Pharmacology & Toxicology and Psychiatry\, I hold the Tier II Canada Research Chair in Molecular Pharmacology of Mood Disorders and the Thomas C. Zachos Chair in Mitochondrial Research. I am also the Founder and Scientific Director of the Mitochondrial Innovation Initiative\, a Senior Fellow of Massey College\, and a Member of the Royal Society of Canada College of New Scholars. \nMy research primarily explores the role of mitochondrial function in health and disease\, focusing on neurological and psychiatric disorders\, organ transplant and regeneration\, and novel therapeutics for mitochondrial health improvement. A key area is the study of mitochondrial function in mood disorders like bipolar disorder (BD)\, where I’ve identified dysregulation in mitochondrial genes and are now using 3D brain organoids to investigate neurotransmission impacts. This could lead to personalized treatments for mood and mitochondrial disorders. In organ transplantation\, my work centers on preserving donor organs\, especially lungs\, and improving transplantation outcomes. This involves studying cell metabolism and mitochondrial health\, contributing to better donor-recipient matches and enhancing patient care. I also pioneer in mitochondrial transplantation and therapy\, exploring the stability\, safety\, and efficacy of mitochondria transplant for regenerative medicine and chronic diseases. \nFinally\, my approach integrates cross-disciplinary collaboration\, intertwining mitochondrial function with various health aspects. Leading the Mitochondrial Innovation Initiative\, I drive advances in mitochondrial biology and its health implications\, promoting knowledge exchange and groundbreaking discoveries for patient and societal benefits. \nThis event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room.
URL:https://mbd.ccrm.ca/event/global-speaker-series-ana-andreazza-phd/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20240117T120000
DTEND;TZID=America/Toronto:20240117T130000
DTSTAMP:20231220T162235Z
CREATED:20231220T162235Z
LAST-MODIFIED:20231220T162235Z
UID:33190-1705492800-1705496400@mbd.ccrm.ca
SUMMARY:Careers Beyond Academia - Christa Studzinski and Paul Nagy
DESCRIPTION:Speakers:\nChrista Studzinski  – Director\, Business Development & Partnerships\, Ontario Brain Institute \nPaul Nagy – Medical Director\, Specialty Care and Oncology\, GSK Canada \n\nCareers Beyond Academia\n“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. For previous recordings of Careers Beyond Academia see here. \nWho Should Attend?\nAttendees should be research trainees‡ who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \n‡ A research trainee is a graduate student\, post-doc\, research associate and/or technician currently working a Canadian lab. \nLearning Objectives:\n\nHelp trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be\nExpose candidates to careers that they might not have previously considered as typical careers in the life sciences\n\n\n\n\n\n\nDate\nConfirmed Speakers\nLink to Register\n\n\n\n\nJanuary 17\, 2024\nChrista Studzinski  – Director\, Business Development & Partnerships\, Ontario Brain Institute \nPaul Nagy – Medical Director\, Specialty Care and Oncology\, GSK Canada\n\n\n\n\nSign up here!
URL:https://mbd.ccrm.ca/event/careers-beyond-academia-christa-studzinski-and-paul-nagy/
CATEGORIES:Career Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20231206T083000
DTEND;TZID=America/Toronto:20231206T180000
DTSTAMP:20230912T130123Z
CREATED:20230823T190308Z
LAST-MODIFIED:20230912T130123Z
UID:20808-1701851400-1701885600@mbd.ccrm.ca
SUMMARY:8th Annual Symposium: Intentional Innovation
DESCRIPTION:
URL:https://mbd.ccrm.ca/event/8th-annual-symposium-intentional-innovation/
LOCATION:MaRS Auditorium\, 101 College Street\, Toronto\, Ontario\, M5G 1L7\, Canada
CATEGORIES:Symposium
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20231115T120000
DTEND;TZID=America/Toronto:20231115T130000
DTSTAMP:20230921T181944Z
CREATED:20230824T141215Z
LAST-MODIFIED:20230921T181944Z
UID:20816-1700049600-1700053200@mbd.ccrm.ca
SUMMARY:Careers Beyond Academia - Ursula Nosi and Shivali Joshi
DESCRIPTION:Speakers:\nUrsula Nosi\, PhD – Scientist I – Process Development\, BlueRock Therapeutics\nShivali Joshi\, PhD – Development Manager\, OmniaBio \nREGISTER HERE\n\nCareers Beyond Academia\n“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. View previous recordings of Careers Beyond Academia here. \nWho Should Attend?\nAttendees should be research trainees‡ who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \n‡ A research trainee is a graduate student\, post-doc\, research associate and/or technician currently working a Canadian lab. \nLearning Objectives:\n\nHelp trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be\nExpose candidates to careers that they might not have previously considered as typical careers in the life sciences\n\nREGISTER HERE
URL:https://mbd.ccrm.ca/event/careers-beyond-academia-3/
CATEGORIES:Career Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20231114T120000
DTEND;TZID=America/Toronto:20231114T130000
DTSTAMP:20231005T173639Z
CREATED:20220714T013512Z
LAST-MODIFIED:20231005T173639Z
UID:17697-1699963200-1699966800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Claudia Fischbach-Teschl\, PhD – Cornell University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nJoin speaker Claudia Fischbach-Teschl\,  Professor\, Biomedical Engineering\, Cornell University\, Director of Cornell’s Physical Sciences Oncology Center (PSOC) on the Physics of Cancer Metabolism\, and Associate Director of Cornell Nanoscale Science and Engineering Facility (CNF). Read more about Professor Fischbach-Teschl. \nHosted by Medicine by Design\, in partnership with the McEwen Stem Cell Institute. \nTalk title: Physical sciences approaches to analyze tumor-associated ECM dynamics. \nRegister here\nAbout Claudia Fischbach-Teschl \n\n  \nClaudia Fischbach-Teschl is the Stanley Bryer 1946 Professor of Biomedical Engineering at Cornell University and Associate Director of Cornell Nanoscale Science and Engineering Facility (CNF). She received her Ph.D. in Pharmaceutical Technology from the University of Regensburg\, Germany and conducted her postdoctoral work at Harvard University in the Division of Engineering and Applied Sciences. Her lab utilizes engineering tools and strategies to gain a better understanding of how tumor-microenvironment interactions regulate cancer development\, progression\, and therapy resistance with a focus on cell-ECM interactions. She is a fellow of the American Institute for Medical and Biological Engineering (AIMBE)\, the Biomedical Engineering Society\, and the Alexander von Humboldt Foundation in Germany. She is the recipient of the Momentum Mid-Career Award by the Cellular and Molecular Bioengineering Special Interest Group of the Biomedical Engineering Society (BMES) and the inaugural awardee of a Rosalind Franklin Award by the Max Planck Centre for Physics in Medicine in Germany. She is a Senior Editor of Cancer Research\, and serves on the Editorial Board of the ACS journal Biomaterials Science and Engineering and Tissue Engineering. She is an advocate for interdisciplinary cancer research and has written Op-Ed articles on this topic including in Scientific American.  \nTalk abstract \nMicroenvironmental conditions contribute to the pathogenesis of cancer and include altered cellular composition\, extracellular matrix (ECM) deposition\, and mechanical cues. However\, our understanding of the specific mechanisms by which these microenvironmental perturbations impact the development\, progression\, and therapy response of cancer is relatively limited. More intricate models are needed to better understand the complex biochemical and biophysical interactions that drive tumor initiation\, growth\, metastasis\, metabolic adaptation\, and immune evasion. The fields of biomaterials and tissue engineering provide increasingly sophisticated tools and strategies to recapitulate and monitor relevant properties of tumor-microenvironment interactions. These approaches not only bear tremendous potential to advance our current understanding of cancer\, but are also increasingly explored for more clinically relevant drug testing. Indeed\, combining patient-specific cells with engineered culture systems promises to enhance the predictive power of precision medicine pipelines. This talk will highlight specific examples of how the microenvironment regulates the highly dynamic nature of cancer and will outline opportunities and challenges of the field of tumor engineering.  \n This event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room.
URL:https://mbd.ccrm.ca/event/global-speaker-series-nov-2023/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20231017T120000
DTEND;TZID=America/Toronto:20231017T130000
DTSTAMP:20230921T134623Z
CREATED:20220714T141111Z
LAST-MODIFIED:20230921T134623Z
UID:17712-1697544000-1697547600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Qizhi Tang\, PhD – University of California\, San Francisco
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Qizhi Tang\, PhD. Professor Tang is a professor of surgery in the Division of Transplant Surgery and director\, Transplantation Research Laboratory from the University of California\, San Francisco. Learn more about the Tang lab. \nRegister for in-person\nThis event will be held in person at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room. \nTalk title: Helping pancreatic beta cells survive after transplant \n\nAbout Qizhi Tang \n\n  \nDr. Qizhi Tang is a professor of immunology in the UCSF Diabetes Center\, the Department of Surgery\, the Gladstone Institute of Genomic Immunology\, and the Institute of Regenerative Medicine at the University of California\, San Francisco (UCSF). She studied medicine at Peking Union Medical College. After a 6-month research internship during year 5 of the 8-year MD program\, she left the program to pursue graduate study in the US. She studied viral immunology at the University of Illinois in Chicago for her PhD. For her postdoctoral fellowship\, she studied cellular and molecular mechanisms of immune tolerance under the tutelage of Jeffrey bluestone\, first at the University Chicago and then at UCSF. She served as the director of the UCSF Transplantation Research Lab for 14 years from 2007 to 2021. She is currently the director of the Northern California JDRF Center of Excellence. \nOne major research focus in the Tang Lab has been on investigating regulatory T cell control of autoimmune diabetes and transplant rejection. In the past 10 years\, she has led translational efforts to design and implement 10 Treg-based clinical trials in autoimmune diseases and organ transplantation. Currently\, pre-clinical research in her lab focuses on developing cellular engineering strategies to enhance human Treg potency and stability. Another area of research in the Tang lab is to optimize beta cell replacement therapy for type 1 diabetes by improving islet survival in ischemia and designing strategies to avoid immune rejection without systemic immunosuppression. \nTalk abstract \nPancreatic beta cell replacement therapy has the potential to cure type 1 diabetes by replacing lost beta cells.  The therapy is limited by the poor survival of the transplanted cells and the need for life-long immunosuppression.  The presentation will describe ongoing efforts to tackle these challenges using cell engineering strategies.
URL:https://mbd.ccrm.ca/event/global-speaker-series-oct-2023/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20231011T120000
DTEND;TZID=America/Toronto:20231011T130000
DTSTAMP:20230926T135356Z
CREATED:20230824T141127Z
LAST-MODIFIED:20230926T135356Z
UID:20814-1697025600-1697029200@mbd.ccrm.ca
SUMMARY:Careers Beyond Academia - Allison Bethune and Josee Champagne
DESCRIPTION:Speakers:\nAllison Bethune\, MSc – Program Manager\, Harquail Centre for Neuromodulation\, Finance\, Strategy and Sustainability\, Sunnybrook Research Institute \nJosee Champagne\, HBSc\, CCRP – Senior Research Associate\, The Ottawa Hospital; Associate Director\, Clinical Development\, Northern Therapeutics; Director of Clinical Development and Business Development\, weCANreg Consulting Group Inc. \n\nCareers Beyond Academia\n“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. For previous recordings of Careers Beyond Academia see here. \nWho Should Attend?\nAttendees should be research trainees‡ who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \n‡ A research trainee is a graduate student\, post-doc\, research associate and/or technician currently working a Canadian lab. \nLearning Objectives:\n\nHelp trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be\nExpose candidates to careers that they might not have previously considered as typical careers in the life sciences\n\n\n\n\n\n\nDate\nConfirmed Speakers\nLink to Register\n\n\n\n\nOctober 11\, 2023\nAllison Bethune\, MSc\, Program Manager\, Harquail Centre for Neuromodulation\, Finance\, Strategy and Sustainability\, Sunnybrook Research Institute \nJosee Champagne\, HBSc\, CCRP\, Senior Research Associate\, The Ottawa Hospital; Associate Director\, Clinical Development\, Northern Therapeutics; Director of Clinical Development and Business Development\, weCANreg Consulting Group Inc.\n\n\n\n\nSign up here!
URL:https://mbd.ccrm.ca/event/careers-beyond-academia-2/
CATEGORIES:Career Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20231003T153000
DTEND;TZID=America/Toronto:20231003T170000
DTSTAMP:20230915T151812Z
CREATED:20230914T174000Z
LAST-MODIFIED:20230915T151812Z
UID:20930-1696347000-1696352400@mbd.ccrm.ca
SUMMARY:Building a Biotech Venture Program Information Session and Networking
DESCRIPTION:Join us on October 3 for an information session to learn about the Building a Biotech Venture program.\nRegister Here\nProgram Information Session and Networking\nOctober 3 from 3:30pm-5:00pm \nONRamp\, 100 College St. Suite 150. \nAt the program information session: \n– Learn how to successfully apply to the program \n– Get an overview of the business canvas\, a key component of the application \n– Hear from previous years’ pitch finalists \n– Network with other interested trainees and/or form a team \n \nTake your first steps toward entrepreneurship with the Building a Biotech Venture program\, where regenerative medicine or precision medicine-focused trainee teams learn from industry experts to develop their venture concepts\, create a pitch deck and business canvas\, and set milestones for building their company. \nThe Building a Biotech Venture program will include a series of workshops where teams will:  \n\nLearn how to think about their research in terms of a product or business\nBuild a business canvas and develop their product or venture concept\nReceive guidance from industry experts on intellectual property\, clinical translation\, and early-stage stage investment\, and preclinical experimental de-risking.\nCreate a pitch deck and receive coaching on telling their venture story\nReceive mentoring throughout the process.\n\nThe program will culminate in a pitch competition where the top teams will receive up to $25\,000 (first place) and $10\,000 (second place) in research funding to advance their venture. \n\n\nPlease email any questions about this program to info.mbd@utoronto.ca.
URL:https://mbd.ccrm.ca/event/building-a-biotech-venture-program-information-session-and-networking/
LOCATION:ONRamp\, 100 College St\, Suite 150\, Toronto\, M5G 1L5\, Canada
CATEGORIES:Partner Events,Workshops
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230926T120000
DTEND;TZID=America/Toronto:20230926T130000
DTSTAMP:20230912T134906Z
CREATED:20220714T141149Z
LAST-MODIFIED:20230912T134906Z
UID:17711-1695729600-1695733200@mbd.ccrm.ca
SUMMARY:Global Speaker Series - Miriam Merad\, MD\, PhD\, Icahn School of Medicine\, Mount Sinai
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Miriam Merad\, MD\, PhD. Miriam Merad is the Director of the Precision Immunology Institute at Mount Sinai School of Medicine in New York and the Director of the Mount Sinai Human Immune Monitoring Center (HIMC). \nTalk title: Targeting myeloid cells in cancer and inflammatory diseases \nThis is a virtual event.\n\nVirtual event links will be sent after registration.\n\nRegister here\n\nAbout Miriam Merad \n\n  \nDr. Merad is an internationally acclaimed physician-scientist and a leader in the fields of dendritic cell and macrophage biology with a focus on their contribution to human diseases. Dr. Merad identified the tissue-resident macrophage lineage and revealed its distinct role in organ physiology and pathophysiology. She established the contribution of this macrophage lineage to cancer progression and inflammatory diseases and is now working on developing novel macrophage-targeted therapies for these conditions. In addition to her work on macrophages\, Dr. Merad is known for her work on dendritic cells\, which control adaptive immunity. She identified a new subset of dendritic cells\, now considered a key antiviral and antitumor immunity target. \nDr. Merad leads the Precision Immunology Institute at the Icahn School of Medicine (PrIISM) to bring immunology discoveries to the clinic. PrIISM integrates immunological research programs with synergistic expertise in biology\, medicine\, technology\, physics\, mathematics\, and computational biology to enhance our understanding of human immunology. She also founded the Human Immune Monitoring Center at Mount Sinai\, one of the world’s most sophisticated research centers\, which uses cutting-edge single-cell technology to understand the contribution of immune cells to major human diseases or treatment responses. \nDr. Merad has authored more than 200 primary papers and reviews in high-profile journals. Her work has been cited several thousand times. She receives generous funding from the National Institutes of Health (NIH) for her research on innate immunity and its contribution to human disease and belongs to several NIH consortia. She is an elected member of the American Society of Clinical Investigation and the recipient of the William B. Coley Award for Distinguished Research in Basic and Tumor Immunology. She is the President of the International Union of Immunological Societies (IUIS). In 2020\, she was elected to the National Academy of Sciences in recognition of her contributions to the field of immunology. \n  \n 
URL:https://mbd.ccrm.ca/event/global-speaker-series-sept-2023/
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230913T120000
DTEND;TZID=America/Toronto:20230913T130000
DTSTAMP:20230810T130311Z
CREATED:20230810T130311Z
LAST-MODIFIED:20230810T130311Z
UID:20742-1694606400-1694610000@mbd.ccrm.ca
SUMMARY:Careers Beyond Academia — Michael Mee and Robyn Butt
DESCRIPTION:Speakers:\n\nMichael Mee\, PhD\, Principal\, Amplitude Ventures\nRobyn Butt\, MsC\, Junior Scientist – Research & Development\, Morphocell Technologies Inc.\n\n\nCareers Beyond Academia\n“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. For previous recordings of Careers Beyond Academia see here. \nWho Should Attend?\nAttendees should be research trainees‡ who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \n‡ A research trainee is a graduate student\, post-doc\, research associate and/or technician currently working a Canadian lab. \nLearning Objectives:\n\nHelp trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be\nExpose candidates to careers that they might not have previously considered as typical careers in the life sciences\n\n\n\n\n\n\nDate\nConfirmed Speakers\nLink to Register\n\n\n\n\nSeptember 13\, 2023\nMichael Mee\, Ph.D\, Principal\, Amplitude Ventures \nRobyn Butt\, MSc\, Junior Scientist – Research & Development\, Morphocell Technologies Inc.\nSign up here!\n\n\n\n\n\n 
URL:https://mbd.ccrm.ca/event/careers-beyond-academia-michael-mee-robyn-butt/
CATEGORIES:Career Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230619T080000
DTEND;TZID=America/Toronto:20230628T170000
DTSTAMP:20230119T171027Z
CREATED:20230119T165641Z
LAST-MODIFIED:20230119T171027Z
UID:19417-1687161600-1687971600@mbd.ccrm.ca
SUMMARY:Summer by Design 2023
DESCRIPTION:How do you move innovative discoveries out of the lab efficiently and effectively so patients benefit sooner? What are the steps involved in translating and commercializing regenerative medicine discoveries? What career opportunities exist beyond academia? \nApply for Summer by Design\, an intensive program for PhD students and post-doctoral fellows from Canadian and international universities\, which will run from June 19 to 28\, 2023\, at the University of Toronto. \nThis eight-day program will feature expert-led\, interactive sessions including lectures\, group work and case studies. \nParticipants will: \n-Make connections with other Summer by Design participants to strengthen their networks of international peers\n-Explore Toronto’s dynamic life sciences hub by meeting with clinical and industry leaders in the field of regenerative medicine\n-Learn from experts across various aspects of the technology translation continuum and be introduced to important topics involved in the business of regenerative medicine including: \n  \nApplications are due on January 23\, 2023. Visit https://mbd.ccrm.ca/opportunities/summer-by-design for more info. \n 
URL:https://mbd.ccrm.ca/event/summer-by-design-2023/
CATEGORIES:Partner Events
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230606T120000
DTEND;TZID=America/Toronto:20230606T130000
DTSTAMP:20230508T200241Z
CREATED:20230411T143207Z
LAST-MODIFIED:20230508T200241Z
UID:19810-1686052800-1686056400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Omolola Eniola-Adefeso\, PhD - University of Michigan
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Omolola Eniola-Adefeso\, PhD\, from the University of Michigan. \nTalk title: Leveraging the Natural Cellular and Biomolecular Interactions in Blood for the Design of Targeted\, Anti-Inflammatory Particle Therapeutics. \nRegister for in-person\nAbout Omolola Eniola-Adefeso \n \nDr. Omolola Eniola-Adefeso is the University Diversity and Social Transformation Professor of Chemical Engineering and Biomedical Engineering at the University of Michigan-Ann Arbor. She received a doctoral degree (2004) in Chemical and Biomolecular Engineering at the University of Pennsylvania. She was a postdoctoral associate in the Pediatrics/Leukocyte Biology at Baylor College of Medicine. Dr. Eniola-Adefeso joined the faculty of Chemical Engineering at the University of Michigan in 2006\, where she runs the Cell Adhesion and Drug Delivery Laboratory. Since she arrived at Michigan\, Dr. Eniola-Adefeso has received several honors and awards\, including the NSF CAREER Award\, American Heart Association Innovator Award\, and most recently\, the BMES MIDCAREER Award. She is a fellow of the American Institute for Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society and serves as Deputy Editor for Science Advances. Her research is currently funded by multiple grants from the NIH NHLBI\, American Heart Association\, and the National Science Foundation. \nTalk abstract \nVascular-targeted particle therapeutics offer the possibility of increased drug effectiveness while minimizing side effects often associated with systemic drug administration. Factors that influence the likelihood of targeted particle therapeutics to reach the vascular wall are the ability to identify: 1) a disease-specific target\, 2) the appropriate drug carrier type and geometry for efficient interaction with the vascular wall\, and 3) a drug-carrier combination that allows for the desired release of the targeted therapeutics. Our work focuses on probing the role of particle geometry\, material chemistry\, and blood rheology/dynamics on the ability of vascular-targeted drug carriers to interact with the blood vessel wall – an important consideration that will control the effectiveness of drug targeting regardless of the targeted disease or delivered therapeutically. This presentation will highlight the carrier-blood cell interactions that affect drug carrier binding to the vascular wall and alter critical neutrophil functions in disease. The talk will present the material design parameters for optimal drug carriers’ design for active and passive use in treating acute lung injury and other inflammatory diseases. \nThis event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room.
URL:https://mbd.ccrm.ca/event/global-speaker-series-lola-eniola-adefeso-phd-university-of-michigan/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230529T140000
DTEND;TZID=America/Toronto:20230529T150000
DTSTAMP:20230117T213444Z
CREATED:20230117T212649Z
LAST-MODIFIED:20230117T213444Z
UID:19390-1685368800-1685372400@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:Please visit the discussion groups page for more information.  \n 
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-22/
LOCATION:Online
CATEGORIES:Discussion Groups
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230424T140000
DTEND;TZID=America/Toronto:20230424T150000
DTSTAMP:20230117T213509Z
CREATED:20230117T212459Z
LAST-MODIFIED:20230117T213509Z
UID:19387-1682344800-1682348400@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:Please visit the discussion groups page for more information.  \n 
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-23/
LOCATION:Online
CATEGORIES:Discussion Groups
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230420T120000
DTEND;TZID=America/Toronto:20230420T130000
DTSTAMP:20230328T132833Z
CREATED:20230104T152027Z
LAST-MODIFIED:20230328T132833Z
UID:19171-1681992000-1681995600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Jean-Laurent Casanova\, MD\, PhD – Rockefeller University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Jean-Laurent Casanova\, MD\, PhD\, from Rockefeller University. \nTalk title: The human genetic and immunological determinants of life-threatening COVID-19 \nRegister for virtual\nRegister for in-person\nAbout Jean-Laurent Casanova\n \n \nJean-Laurent Casanova received his MD in 1987 and his PhD in 1992\, after training at the Pasteur Institute in Paris and the Ludwig Institute for Cancer Research in Lausanne. He was appointed professor at Necker in 1999 and with Laurent Abel\, co-founded the Laboratory of Human Genetics of Infectious Diseases. He was appointed professor at Rockefeller University in 2008 and named HHMI investigator in 2014. He continues to partner with Dr. Abel\, maintaining their lab in Paris and NY. \nCasanova studies the human genetic and immunological determinants of life-threatening infectious diseases. He searches for rare and common single-gene mutations that selectively compromise immunity of otherwise healthy individuals who are vulnerable to specific infectious diseases. He then searches for other causes disrupting the same mechanisms of host defense\, and thus characterizes the causal mechanisms of life-threatening infectious diseases. \nTalk abstract\nAutosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare\, biochemically deleterious X-linked TLR7 variants in 16 unrelated male individuals aged 7 to 71 years (mean: 36.7 years) from a cohort of 1\,202 male patients aged 0.5 to 99 years (mean: 52.9 years) with unexplained critical COVID-19 pneumonia. None of the 331 asymptomatically or mildly infected male individuals aged 1.3 to 102 years (mean: 38.7 years) tested carry such TLR7 variants (p = 3.5 × 10-5). The phenotypes of five hemizygous relatives of index cases infected with SARS-CoV-2 include asymptomatic or mild infection (n=2\, 5 and 38 years)\, or moderate (n=1\, 5 years)\, severe (n=1\, 27 years)\, or critical (n=1\, 29 years) pneumonia. Two boys (aged 7 and 12 years) from a cohort of 262 male patients with severe COVID-19 pneumonia (mean: 51.0 years) are hemizygous for a deleterious TLR7 variant. The cumulative allele frequency for deleterious TLR7 variants in the male general population is < 6.5×10-4 We also show that blood B cell lines and myeloid cell subsets from the patients do not respond to TLR7 stimulation\, a phenotype rescued by wild-type TLR7 The patients’ blood plasmacytoid dendritic cells (pDCs) produce low levels of type I IFNs in response to SARS-CoV-2. Overall\, X-linked recessive TLR7 deficiency is a highly penetrant genetic etiology of critical COVID-19 pneumonia\, in about 1.8% of male patients below the age of 60 years. Human TLR7 and pDCs are essential for protective type I IFN immunity against SARS-CoV-2 in the respiratory tract. Furthermore\, circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL\, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia\, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower\, more physiological\, concentrations of IFN-α and/or -ω (100 pg/mL\, in 1/10 dilutions of plasma) in 13.6% of 3\,595 patients with critical COVID-19\, including 21% of 374 patients > 80 years\, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1\,124 deceased patients (aged 20 days-99 years; mean: 70 years). Moreover\, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neutralizing high concentrations of IFN-β. We also show\, in a sample of 34\,159 uninfected subjects from the general population\, that auto-Abs neutralizing high concentrations of IFN-α and/or -ω are present in 0.18% of individuals between 18 and 69 years\, 1.1% between 70 and 79 years\, and 3.4% >80 years. Moreover\, the proportion of subjects carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10\,778 uninfected individuals: 1% of individuals <70 years\, 2.3% between 70 and 80 years\, and 6.3% >80 years. By contrast\, auto-Abs neutralizing IFN-β do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over-80s\, and total fatal COVID-19 cases.
URL:https://mbd.ccrm.ca/event/global-speaker-series-jean-laurent-casanova-phd/
LOCATION:ONRamp\, 100 College St\, Suite 150\, Toronto\, M5G 1L5\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230420T113000
DTEND;TZID=America/Toronto:20230420T123000
DTSTAMP:20230125T174449Z
CREATED:20230125T174449Z
LAST-MODIFIED:20230125T174449Z
UID:19455-1681990200-1681993800@mbd.ccrm.ca
SUMMARY:Modelling Cell Development & Regeneration Discussion Group
DESCRIPTION:Please visit the discussion groups page for more information.
URL:https://mbd.ccrm.ca/event/modelling-cell-development-regeneration-discussion-group-24/
LOCATION:Online
CATEGORIES:Discussion Groups
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230417T100000
DTEND;TZID=America/Toronto:20230417T110000
DTSTAMP:20230125T174350Z
CREATED:20230125T174350Z
LAST-MODIFIED:20230125T174350Z
UID:19457-1681725600-1681729200@mbd.ccrm.ca
SUMMARY:Modelling Cell Development & Regeneration Discussion Group
DESCRIPTION:Please visit the discussion groups page for more information.
URL:https://mbd.ccrm.ca/event/modelling-cell-development-regeneration-discussion-group-23/
LOCATION:Online
CATEGORIES:Discussion Groups
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230327T140000
DTEND;TZID=America/Toronto:20230327T150000
DTSTAMP:20230117T213458Z
CREATED:20230117T204040Z
LAST-MODIFIED:20230117T213458Z
UID:19385-1679925600-1679929200@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:Please visit the discussion groups page for more information.  \n 
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-16/
LOCATION:Online
CATEGORIES:Discussion Groups
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230323T100000
DTEND;TZID=America/Toronto:20230323T110000
DTSTAMP:20230125T174258Z
CREATED:20230125T174258Z
LAST-MODIFIED:20230125T174258Z
UID:19454-1679565600-1679569200@mbd.ccrm.ca
SUMMARY:Modelling Cell Development & Regeneration Discussion Group
DESCRIPTION:Please visit the discussion groups page for more information.
URL:https://mbd.ccrm.ca/event/modelling-cell-development-regeneration-discussion-group-22/
LOCATION:Online
CATEGORIES:Discussion Groups
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230320T110000
DTEND;TZID=America/Toronto:20230320T120000
DTSTAMP:20230125T174115Z
CREATED:20230125T174115Z
LAST-MODIFIED:20230125T174115Z
UID:19448-1679310000-1679313600@mbd.ccrm.ca
SUMMARY:Modelling Cell Development & Regeneration Discussion Group
DESCRIPTION:Please visit the discussion groups page for more information.
URL:https://mbd.ccrm.ca/event/modelling-cell-development-regeneration-discussion-group-21/
LOCATION:Online
CATEGORIES:Discussion Groups
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230315T120000
DTEND;TZID=America/Toronto:20230315T130000
DTSTAMP:20230218T194710Z
CREATED:20230104T172944Z
LAST-MODIFIED:20230218T194710Z
UID:19207-1678881600-1678885200@mbd.ccrm.ca
SUMMARY:Careers Beyond Academia
DESCRIPTION:  \nVirtutal event: Register here\nAbout the series“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. \nWho should attend? Attendees should be research trainees (graduate students\, post-doctoral fellows\, research associates and/or technicians currently working Canadian labs) who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \nLearning objectives Help trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be Expose candidates to careers that they might not have previously considered as typical careers in the life sciences.
URL:https://mbd.ccrm.ca/event/careers-beyond-academia/
LOCATION:Virtual
CATEGORIES:Career Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230314T130000
DTEND;TZID=America/Toronto:20230314T140000
DTSTAMP:20230222T191147Z
CREATED:20230104T143408Z
LAST-MODIFIED:20230222T191147Z
UID:19172-1678798800-1678802400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Domitilla Del Vecchio\, PhD – Massachusetts Institute of Technology
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Domitilla Del Vecchio\, PhD\, from the Massachusetts Institute of Technology. \nTalk title: Synthetic genetic circuits to uncover and enforce the OCT4 trajectories of successful reprogramming of human fibroblasts. \nRegister for virtual\nRegister for in-person\nAbout the Del Vecchio lab\n \n \nDomitilla Del Vecchio received the PhD degree in Control and Dynamical Systems from the California Institute of Technology\, Pasadena\, and the Laurea degree in Electrical Engineering (Automation) from the University of Rome at Tor Vergata in 2005 and 1999\, respectively. From 2006 to 2010\, she was an Assistant Professor in the Department of Electrical Engineering and Computer Science and in the Center for Computational Medicine and Bioinformatics at the University of Michigan\, Ann Arbor. In 2010\, she joined the Department of Mechanical Engineering at the Massachusetts Institute of Technology (MIT)\, where she is currently Professor and member of the Synthetic Biology Center. She is a Fellow of the International Federation of Automatic Control (2022)\, an IEEE Fellow (2021)\, and a recipient of the Newton Award for Transformative Ideas during the COVID-19 Pandemic (2020)\, the 2016 Bose Research Award (MIT)\, the Donald P. Eckman Award from the American Automatic Control Council (2010)\, the NSF Career Award (2007)\, the American Control Conference Best Student Paper Award (2004)\, and the Bank of Italy Fellowship (2000). Her research focuses on developing techniques to make synthetic genetic circuits robust to context and on applying these to biosensing and cell fate control for regenerative medicine applications. \n  \nTalk abstract\nReprogramming human fibroblasts to induced pluripotent stem cells (iPSCs) is inefficient\, with heterogeneity among transcription factor (TF) trajectories driving divergent cell states. Nevertheless\, the impact of TF dynamics on reprogramming efficiency remains uncharted. In this work\, we identify the successful reprogramming trajectories of the core pluripotency TF\, OCT4\, and design a genetic controller that enforces such trajectories with high precision. By combining a genetic circuit that generates a wide range of OCT4 trajectories with live cell imaging\, we track OCT4 trajectories with clonal resolution and find that a distinct constant OCT4 trajectory is required for colony formation. We then develop a genetic controller circuit that yields a tight OCT4 distribution around the identified trajectory. In terms of reprogramming efficiency\, this controller outperforms other circuits that less accurately regulate OCT4. Our approach is generalizable for identifying and enforcing TF dynamics for cell fate programming applications.
URL:https://mbd.ccrm.ca/event/global-speaker-series-domitilla-del-vecchio-phd/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230227T140000
DTEND;TZID=America/Toronto:20230227T150000
DTSTAMP:20230117T213520Z
CREATED:20230117T203946Z
LAST-MODIFIED:20230117T213520Z
UID:19383-1677506400-1677510000@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:Please visit the discussion groups page for more information.  \n 
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-24/
LOCATION:Online
CATEGORIES:Discussion Groups
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20230223T130000
DTEND;TZID=America/Toronto:20230223T140000
DTSTAMP:20230206T185723Z
CREATED:20220714T012204Z
LAST-MODIFIED:20230206T185723Z
UID:17688-1677157200-1677160800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Jeff Biernaskie\, PhD – University of Calgary
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. Medicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Jeff Biernaskie\, PhD\, from the University of Calgary. \nTalk title: Insights into the determinants of tissue regeneration versus scar formation. \nThis is a hybrid event. Register for the in-person or virtual option. Lunch will be served to in-person registrants. \nThis event is also being sponsored by the Collaborative Specialization in Developmental Biology. \nRegister now for virtual\nRegister now for in-person  \nAbout the Biernaskie lab\n \n \nDr. Biernaskie completed his BSc in Neuroscience at the University of Lethbridge. He earned a PhD in Neuroscience at Memorial University studying the effects of focused rehabilitative experience on brain plasticity following stroke. He completed postdoctoral training with Freda Miller and David Kaplan studying skin and neural stem cell biology at the Hospital for Sick Children in Toronto. In 2009\, he joined the Faculty of Veterinary Medicine at the University of Calgary\, where is he currently a Professor in Stem Cell Biology and Regenerative Medicine. He is a member of the Alberta Children’s Hospital Research Institute and the Hotchkiss Brain Institute and he holds the Calgary Firefighters Burn Treatment Society Chair in Skin Regeneration and Wound Healing. In 2019\, he was elected as a member of the Royal Society of Canada\, College of Scholars\, Artists and Scientists. \nHis research program is focused on understanding the cellular and molecular mechanisms that promote fibrotic versus regenerative healing with the goal of developing treatments to restore organ function following injury or disease. His group is also interested in how skin and brain stem/progenitor cells are regulated during homeostasis and how factors like injury\, advanced aging and the immune system impact their function. \nTalk abstract\nAdult mammals have evolved to heal deep skin wounds by forming fibrotic scar in order to most efficiently fill the defect and support reepithelialisation to prevent infection. But it is unclear as to the mechanisms that drive this propensity and whether there are ways to re-awaken pro-regenerative processes in order to better restore normal function to the healed skin. I will describe our work in captive adult reindeer which provides a powerful comparative model of scarless versus fibrotic skin wound healing. Full-thickness injuries of reindeer antler skin (velvet) exhibit near-complete regeneration\, whereas back skin forms fibrotic scar. By employing single-cell multi-omics we found that even prior to injury\, velvet demal fibroblasts exhibit a transcriptional ground state that resembles human fetal fibroblasts\, whereas back skin fibroblasts express inflammatory mediators mimicking pro-fibrotic adult human and rodent fibroblasts. As a consequence of these distinct resting states\, skin injury elicited site-specific immune responses: back skin fibroblasts amplifying myeloid infiltration and maturation\, whereas velvet fibroblasts adopted an immunosuppressive phenotype that restricted leukocyte recruitment and hastened immune resolution. Finally\, I will describe additional experiments that highlight a critical role for fibroblasts in orchestrating local immune function during wound healing and that decoupling these fibroblast-immune interactions may be a promising approach to mitigate scar.
URL:https://mbd.ccrm.ca/event/global-speaker-series-feb-2023/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
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DTSTART;TZID=America/Toronto:20230222T110000
DTEND;TZID=America/Toronto:20230222T120000
DTSTAMP:20230125T173321Z
CREATED:20230125T173321Z
LAST-MODIFIED:20230125T173321Z
UID:19449-1677063600-1677067200@mbd.ccrm.ca
SUMMARY:Modelling Cell Development & Regeneration Discussion Group
DESCRIPTION:Please visit the discussion groups page for more information.
URL:https://mbd.ccrm.ca/event/modelling-cell-development-regeneration-discussion-group-20/
LOCATION:Online
CATEGORIES:Discussion Groups
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DTSTART;TZID=America/Toronto:20230216T120000
DTEND;TZID=America/Toronto:20230216T130000
DTSTAMP:20230104T172528Z
CREATED:20230104T171450Z
LAST-MODIFIED:20230104T172528Z
UID:19200-1676548800-1676552400@mbd.ccrm.ca
SUMMARY:Careers Beyond Academia: Jodi Garner\, Roche\, & Patrycja Thompson\, University of Toronto
DESCRIPTION:Speakers Jodi Garner\, PhD Strategic Collaborations Lead\, Roche Patrycja Thompson\, PhD Partnerships Officer\, Strategic Initiatives Industry Partnerships\, University of Toronto \nVirtual Event – Register Here\nAbout the series“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. \nWho should attend? Attendees should be research trainees (graduate students\, post-doctoral fellows\, research associates and/or technicians currently working Canadian labs) who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \nLearning objectives Help trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be Expose candidates to careers that they might not have previously considered as typical careers in the life sciences.
URL:https://mbd.ccrm.ca/event/careers-beyond-academia-jodi-garner-roche-patrycja-thompson-university-of-toronto/
LOCATION:Virtual
CATEGORIES:Career Speaker Series
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DTSTART;TZID=America/Toronto:20230214T153000
DTEND;TZID=America/Toronto:20230214T163000
DTSTAMP:20230206T174817Z
CREATED:20230203T203418Z
LAST-MODIFIED:20230206T174817Z
UID:19503-1676388600-1676392200@mbd.ccrm.ca
SUMMARY:Healthy & Inclusive Labs Trainee Town Hall
DESCRIPTION:What makes a healthy lab environment? What can be done to better support you as a trainee? Share your thoughts at the Healthy & Inclusive Labs Trainee Town Hall! \nJoin us for a crucial town hall discussion on the challenges impacting the social health of your lab. We want to hear your perspective on what could be done to create lab environments that better support equity\, diversity and inclusion\, mental health\, and overall performance. Your feedback will help Medicine by Design’s Healthy and Inclusive Labs Committee develop more effective and relevant event programming. \n  \nRegister now\n  \nTo help guide our discussions at the town hall\, we ask that you fill out this survey. We would love to have your input even if you can’t attend!
URL:https://mbd.ccrm.ca/event/healthy-incl-labs-town-hall/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Healthy & Inclusive Labs
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