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X-WR-CALDESC:Events for Medicine by Design
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DTSTART:20170312T070000
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DTSTART;TZID=America/Toronto:20190228T120000
DTEND;TZID=America/Toronto:20190228T130000
DTSTAMP:20260406T022700
CREATED:20181220T172404Z
LAST-MODIFIED:20191125T194331Z
UID:6234-1551355200-1551358800@mbd.ccrm.ca
SUMMARY:Career Speaker Series: Omar F. Khan\, Tiba Biotech\, LLC
DESCRIPTION:Learn more and register
URL:https://mbd.ccrm.ca/event/career-speaker-series-omar-f-khan/
CATEGORIES:Career Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190122T120000
DTEND;TZID=America/Toronto:20190122T130000
DTSTAMP:20260406T022700
CREATED:20181210T163443Z
LAST-MODIFIED:20191126T154151Z
UID:6151-1548158400-1548162000@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Peter Reddien\, PhD - Massachusetts Institute of Technology
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Peter Reddien\, PhD\, a professor in the Department of Biology at the Massachusetts Institute of Technology. He will give a talk titled\, “The essential components of regeneration.” \nDownload event poster \nThis event will be livestreamed (link will be live shortly before event) \nTalk Abstract\nHow animals regenerate missing body parts is one of the great mysteries of biology. Planarians are flatworms capable of some of the most dramatic known feats of animal regeneration\, including regeneration of new heads. We have uncovered a key set of minimal components and concepts needed to explain how these animals accomplish their regenerative feats. \nBiography\nLearn more about Peter Reddien
URL:https://mbd.ccrm.ca/event/global-speaker-series-peter-reddien-january-2019/
LOCATION:Mount Sinai Hospital\, Ben Sadowski Auditorium\, 18th floor\, 600 University Avenue\, Toronto\, Ontario\, M5G 1X5\, Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190121T150000
DTEND;TZID=America/Toronto:20190121T160000
DTSTAMP:20260406T022700
CREATED:20190116T151320Z
LAST-MODIFIED:20191125T194331Z
UID:6332-1548082800-1548086400@mbd.ccrm.ca
SUMMARY:Special Seminar: Kaitlyn Sadtler\, PhD
DESCRIPTION:The Institute of Biomaterials & Biomedical Engineering and Medicine by Design present a special seminar by Kaitlyn Sadtler\, PhD. The title of her talk is “Harnessing the Immune System in Regenerative Medicine.” Learn more
URL:https://mbd.ccrm.ca/event/special-seminar-kaitlyn-sadtler-phd/
LOCATION:Canada
CATEGORIES:Other Events
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190111T120000
DTEND;TZID=America/Toronto:20190111T130000
DTSTAMP:20260406T022700
CREATED:20181220T172129Z
LAST-MODIFIED:20191125T194331Z
UID:6231-1547208000-1547211600@mbd.ccrm.ca
SUMMARY:Career Speaker Series: Azadeh Golipour\, AVROBIO\, Inc.
DESCRIPTION:Learn more and register
URL:https://mbd.ccrm.ca/event/career-speaker-series-azadeh-golipour-avrobio-inc/
CATEGORIES:Career Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181211T120000
DTEND;TZID=America/Toronto:20181211T133000
DTSTAMP:20260406T022700
CREATED:20180820T142558Z
LAST-MODIFIED:20191125T194331Z
UID:5658-1544529600-1544535000@mbd.ccrm.ca
SUMMARY:Computational Biology Discussion Group
DESCRIPTION:Professor Rudi Winklbauer from the Department of Cell & Systems Biology will give a talk titled “Adhesion mechanisms for a vast range of cell adhesion strengths.” \nFor more information about topics and speakers and to register\, please contact Maria Abou Chakra or Himanshu Kaul. This group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n Learn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/compbio-discussion-december-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181204T080000
DTEND;TZID=America/Toronto:20181204T171500
DTSTAMP:20260406T022700
CREATED:20180814T223719Z
LAST-MODIFIED:20191126T153340Z
UID:5567-1543910400-1543943700@mbd.ccrm.ca
SUMMARY:Medicine by Design Symposium
DESCRIPTION:REGISTRATION IS CLOSED – WE HAVE REACHED CAPACITY\nTHE DEADLINE TO SUBMIT POSTER ABSTRACTS WAS OCT. 10. WE ARE NO LONGER ACCEPTING POSTER ABSTRACTS.\nCell and Gene Therapy\n\nThe third annual Medicine by Design Symposium will bring together principal investigators and trainees from across the University of Toronto and affiliated hospitals\, along with members of our Scientific Advisory Board\, to share research and ignite new collaborations. Session themes include: \n\nGene engineering\nImmune engineering\nMuscle engineering\nNeural engineering\n\nThe symposium will also include an opportunity for trainees in Medicine by Design-funded labs to present their research during a poster session. \n\nInvited Speakers\n \n\n\nRegistration\nREGISTRATION HAS CLOSED \n\nAgenda and Poster List\nAgenda – FINAL \nPoster Index \n\nFlyer\nDownload the symposium flyer
URL:https://mbd.ccrm.ca/event/symposium-2018/
LOCATION:101 College Street\, Toronto\, Ontario\, M5G 1L7\, Canada
CATEGORIES:Symposium
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181127T120000
DTEND;TZID=America/Toronto:20181127T133000
DTSTAMP:20260406T022700
CREATED:20180814T221947Z
LAST-MODIFIED:20191125T194331Z
UID:5565-1543320000-1543325400@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Keith Pardee\, an assistant professor at the Leslie Dan Faculty of Pharmacy\, will give a talk on “Cell-free Synthetic Biology:  Rapid\, Low-cost Tools for Human Health.” \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and received information about upcoming meetings\, please contact Laura Prochazka. \nTalk Abstract\nWe see cell-free technologies as important tools in meeting challenges that face health care systems at home and abroad.  As we have demonstrated\, cell-free hosting of diagnostics and drug manufacturing offers a paradigm shift in how health care systems can adapt rapidly to public health needs\, provide emergency response and extend lab-grade molecular capabilities into virtually any environment.  Such applications are enabled by freeze-dried cell-free (FD-CF) enzymes that are sterile yet retain the properties of cellular transcription and translation for deploying poised molecular components to the field.  \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/synbio-discussion-november-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181120T120000
DTEND;TZID=America/Toronto:20181120T130000
DTSTAMP:20260406T022700
CREATED:20180820T150235Z
LAST-MODIFIED:20191126T153521Z
UID:5670-1542715200-1542718800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Marlene Rabinovitch\, MD\, Stanford University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Marlene Rabinovitch\, MD\, the Dwight and Vera Dunlevie Professor in Pediatric Cardiology at Stanford University. She will give a talk titled\, “Impact of shear stress on chromatin accessibility and gene regulation.” \nDownload poster \nThis talk will be be live streamed \nTalk Abstract\nIt is well known that laminar shear stress as opposed to static or disturbed flow induces vasculoprotective endothelial (EC) genes such as endothelial nitric oxide synthase (eNOS)\, but how changes in flow affect chromatin accessibility at specific transcription factor binding sites is not known. We used the Ibidi flow system with cultured pulmonary arterial (PA) EC and applied ATAC Seq\, ChIPSeq and RNA Seq to determine why certain regions of chromatin open and others close to regulate a distinct program of gene expression. We determined by mass spectrometry and proximity ligation analysis that KLF4 interacts with the Brg complex of chromatin remodelers under laminar flow to regulate genes that protect endothelial cells and that ATF2 interacts with the Brg complex of chromatin remodelers under static or disturbed flow\, to regulate genes that can perturb endothelial function and lead to a pro-inflammatory milieu. We harvested EC from patients with pulmonary arterial hypertension (PAH) associated with a congenital heart defect but could not observe a phenotype that distinguished these from control EC under static or laminar flow conditions.  Based upon computer modeling of a congenital heart defect with PAH\, we subjected the EC to high shear\, 100 or 170 dynes cm2.  In both cases we saw evidence of high eNOS and eNOS un-coupling resulting in an increase in reactive oxygen species (ROS). RNA sequencing revealed increased cholesterol biosynthesis and activation of GTPase that can alter caveoli and result in eNOS uncoupling\, ROS production and perturbation of normal endothelial cell function. \nBiography\nDr. Rabinovitch is the Dwight and Vera Dunlevie Professor in Pediatric Cardiology\, at Stanford University School of Medicine. Dr. Rabinovitch graduated from McGill University Medical School and completed her pediatrics training at the University of Colorado and sub-specialty training in cardiology at Boston Children’s Hospital\, Harvard Medical School\, where she was Assistant Professor. She then became Professor of Pediatrics\, Laboratory Medicine and Pathobiology and Medicine at the University of Toronto\, Director of the Cardiovascular Research Program at the Hospital for Sick Children and the Robert M. Freedom/Heart and Stroke Foundation Chair. \nDr. Rabinovitch has received numerous awards for her research and mentoring. These include: \n\n2017: the American Heart Association Distinguished Scientist Lecturer;\n2016: the prestigious J. Burns Amberson Lectureship from the American Thoracic Society\, and the Robert F. Grover Prize from the Assembly on Pulmonary Circulation;\n2015: Mentorship Awards from the Association for Women in Science and the Stanford Department of Pediatrics;\n2012: the Judith Pool Mentorship Award;\n2010: the Louis and Artur Lucian Award for Research in Circulatory Diseases from McGill University:\n2008: the Recognition Award for Scientific Accomplishment from ATS;\n2006: the American Heart Association’s (AHA) Distinguished Scientist Award;\n2004: AHA’s Basic Research Prize\, and the Canadian Institute of Circulatory and Respiratory Health Lectureship and Prize; and\n2003: the Gill Heart Institute Award for Outstanding Contributions to Cardiovascular Research.\n\nShe has given numerous named lectureships\, including the AHA Paul Dudley White and Dickinson Richards Lectures\, as well as the American Physiological Society Julius Comroe Lecture. She has served as Visiting Professor in many countries worldwide and has over 190 peer-reviewed publications and 124 invited reviews and book chapters. \nDr. Rabinovitch is currently the Director of the Basic Science and Engineering Initiative of the Betty Irene Moore Children’s Heart Center at Stanford University. In addition\, she is the Associate Director in Basic Research at Stanford’s Cardiovascular Institute and on the Executive Committee of the Pulmonary Vascular Research Institute. She has recently served as an External Advisor to the NHLBI Lung Regeneration Program\, the Max Planck Institute for Heart and Lung Research and the German Lung Centers of Excellence\, and has also served on the Scientific Advisory Councils of NHLBI as well as numerous other Research Foundations. She is a member of the American Society for Clinical Investigation\, and the Association of American Physicians\, and has been Associate Editor of Circulation Research and Annual Reviews of Physiology. Her research focuses on uncovering fundamental genetic\, metabolic\, and inflammatory mechanisms causing pulmonary hypertension that can be translated to the clinic.
URL:https://mbd.ccrm.ca/event/global-speaker-series-marlene-rabinovitch-november-2018/
LOCATION:Mount Sinai Hospital\, Ben Sadowski Auditorium\, 18th floor\, 600 University Avenue\, Toronto\, Ontario\, M5G 1X5\, Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181113T120000
DTEND;TZID=America/Toronto:20181113T133000
DTSTAMP:20260406T022700
CREATED:20180820T142410Z
LAST-MODIFIED:20191125T194332Z
UID:5656-1542110400-1542115800@mbd.ccrm.ca
SUMMARY:Computational Biology Discussion Group
DESCRIPTION:The Computational Biology Discussion Group will meet. For more information about topics and speakers and to register\, please contact Maria Abou Chakra or Himanshu Kaul. This group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n Learn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/compbio-discussion-november-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181030T120000
DTEND;TZID=America/Toronto:20181030T133000
DTSTAMP:20260406T022700
CREATED:20180814T221116Z
LAST-MODIFIED:20191125T194332Z
UID:5561-1540900800-1540906200@mbd.ccrm.ca
SUMMARY:Computational and Synthetic Biology Discussion Groups
DESCRIPTION:Kaushik Raj\, a PhD candidate in the laboratory of Professor Krishna Mahadevan (Department of Chemical Engineering & Applied Chemistry)\, will give a talk on “Emergent properties in gene regulation”. \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. \nTalk Abstract\nThis talk will focus on how simple motifs in gene regulatory networks come together to result in complex regulatory programs\, and how mathematical models can help us study them. A special emphasis will be given to modelling and engineering bistability in biological systems. \nLearn more about Medicine by Design discussion groups\n\n 
URL:https://mbd.ccrm.ca/event/joint-discussion-october-2018-2/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181025T160000
DTEND;TZID=America/Toronto:20181025T170000
DTSTAMP:20260406T022700
CREATED:20181017T140619Z
LAST-MODIFIED:20191125T194332Z
UID:5873-1540483200-1540486800@mbd.ccrm.ca
SUMMARY:Seminar: Frank Barry\, PhD\, National University of Ireland Galway
DESCRIPTION:Frank Barry\, a professor of cellular therapy at the Regenerative Medicine Institute at the National University of Ireland Galway\, will present a talk on “Cell-based therapies for osteoarthritis: Progress and obstacles.” This talk is hosted by the Collaborative Specialization in Musculoskeletal Sciences at the University of Toronto.
URL:https://mbd.ccrm.ca/event/seminar-frank-barry-phd-national-university-of-ireland-galway/
LOCATION:Medical Sciences Building\, Room 4227\, 1 King's College Circle\, Toronto\, Ontario\, M5S 3K1\, Canada
CATEGORIES:External Events
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181016T120000
DTEND;TZID=America/Toronto:20181016T130000
DTSTAMP:20260406T022700
CREATED:20180814T224231Z
LAST-MODIFIED:20191126T153439Z
UID:5570-1539691200-1539694800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Jennifer Elisseeff\, PhD\, Johns Hopkins University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Jennifer Elisseeff\, PhD\, Professor and Director\, Translational Tissue Engineering Center\, Wilmer Eye Institute and departments of Biomedical Engineering\, Orthopedic Surgery\, Chemical and Biological Engineering\, and Materials Science and Engineering at Johns Hopkins University. The title of her talk is “Lessons from translation and the development of regenerative immunotherapies”. \nDownload event poster \nThis talk will be be live streamed \nAbstract\nThe immune system is the first responder to trauma and foreign bodies such as biomaterials\, yet this response and its capacity to orchestrate tissue repair has been largely ignored. Today\, biomaterials can be engineered with exquisite control over physical properties and can present an array of spatially controlled biological cues. Until now\, these scaffolds have directly targeted stem cells\, vascular development\, and differentiated cells to stimulate tissue formation or wound healing. Translating tissue engineering technologies to the clinic\, we discovered cells from adaptive immune system responded to the biomaterials. We profiled in depth the immunological response to the wound environment in combination with biological scaffolds. The adaptive immune system\, specifically Th2 T cells\, is required for the scaffold stimulation of wound repair. We are now investigating in detail the innate and adaptive immune response to synthetic versus biological scaffolds and possible candidates for tissue stroma-immune regulation. In parallel\, we are exploiting these discoveries to design immunomodulatory materials for tissue repair. Ultimately\, targeting the immune system represents a paradigm shift for the field and will help to realize the promise of regenerative medicine. \nBiography\nJennifer Elisseeff is the Morton Goldberg Professor and Director of the Translational Tissue Engineering Center at Johns Hopkins University’s Department of Biomedical Engineering and the Wilmer Eye Institute\, with appointments in Chemical and Biological Engineering\, Materials Science and Orthopedic Surgery. She was elected a Fellow of the American Institute of Medical and Biological Engineering\, the National Academy of Inventors\, and a Young Global Leader by World Economic Forum. In 2018\, she was elected to the National Academy of Engineering. \nJennifer received a bachelor’s degree in chemistry from Carnegie Mellon University and a PhD in medical engineering from the Harvard–MIT Division of Health Sciences and Technology. Later she was a Fellow at the National Institute of General Medical Sciences\, Pharmacology Research Associate Program\, where she worked in the National Institute of Dental and Craniofacial Research. She has published over 200 papers\, book chapters\, and patent applications and received a number of awards including the Carnegie Young Alumni Award. In 2002\, she was named by MIT Technology Review as a top innovator under 35. \nJennifer’s research focus is the development of biomaterials for regenerative medicine applications in orthopedics\, plastic and reconstructive surgery\, and ophthalmology.  She is now studying biomaterials-directed regenerative immunology and the role of the adaptive immune system in tissue repair.  She is committed to the translation of regenerative biomaterials and has founded several companies and participates in several industry advisory boards.
URL:https://mbd.ccrm.ca/event/global-speaker-series-2018-october/
LOCATION:Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181002T120000
DTEND;TZID=America/Toronto:20181002T133000
DTSTAMP:20260406T022700
CREATED:20180820T162328Z
LAST-MODIFIED:20191125T194345Z
UID:5699-1538481600-1538487000@mbd.ccrm.ca
SUMMARY:Computational and Synthetic Biology Discussion Groups
DESCRIPTION:Nicole Mideo\, an assistant professor in the Department of Ecology and Evolutionary Biology\, will give a talk titled “Multiscale models for predicting parasite life history.” \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n Learn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/joint-discussion-october-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180918T120000
DTEND;TZID=America/Toronto:20180918T130000
DTSTAMP:20260406T022700
CREATED:20180814T224618Z
LAST-MODIFIED:20191126T153657Z
UID:5573-1537272000-1537275600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Ke Cheng\, PhD\, North Carolina State University/UNC-Chapel Hill
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Ke Cheng\, PhD\, associate professor in the Department of Molecular and Biomedical Sciences at North Carolina State University’s College of Veterinary Medicine and associate professor in the joint Department of Biomedical Engineering at North Carolina State University and the University of North Carolina at Chapel Hill. The title of his talk is “Cell Therapy by Design: Biomaterials and Bioengineering Approaches for More Potent Cell Therapies”. \nDownload event poster \nThis talk will be be live streamed \nAbstract\nNo therapy currently available can reduce the size of an established scar on the heart. Cell therapy aims to alter this fixed trajectory for MI survivors: to intervene adverse heart remodelling\, to reduce scar size\, and to actually regenerate viable myocardial tissue. The last one and half decades witnessed the booming of stem cell therapies for multiple diseases. Our lab has been studying stem cell therapy for heart regeneration in the past decade. Efficacy in cell transplantation is hampered by many hurdles\, including low rates of cell retention and engraftment\, poor targeting to the injury site\, and unstable cell quality during long-term storage. We have developed multiple ​bioengineering strategies to enhance the delivery of stem cells. In addition\, we have been studying alternative mechanisms that can explain the extravasation of injected cells. \nBiography\nDr. Ke Cheng is professor of biomedical engineering and veterinary medicine at UNC-Chapel Hill and NC State University\, where he also serves as the associate director of the Comparative Medicine Institute. His research focuses on stem cells\, biomaterials and nanomedicine approaches for regenerative medicine applications. More particularly\, the results from the Cheng lab have translated into new therapies for cardiovascular and pulmonary diseases such as myocardial infarction and pulmonary fibrosis\, including recently completed and ongoing clinical trials in human patients. The lab has been continuously supported by the National Institutes of Health and has published results in journals such as Nature Biomedical Engineering\, Nature Communications\, Circulation Research\, ACS Nano and Theranostics.
URL:https://mbd.ccrm.ca/event/global-speaker-series-2018-september/
LOCATION:Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180911T120000
DTEND;TZID=America/Toronto:20180911T133000
DTSTAMP:20260406T022700
CREATED:20180809T160748Z
LAST-MODIFIED:20191125T194345Z
UID:5426-1536667200-1536672600@mbd.ccrm.ca
SUMMARY:Computational Biology Discussion Group
DESCRIPTION:The Computational Biology Discussion Group will meet. For more information about topics and speakers and to register\, please contact Maria Abou Chakra or Himanshu Kaul. This group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n Learn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/compbio-discussion-september-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180828T120000
DTEND;TZID=America/Toronto:20180828T133000
DTSTAMP:20260406T022700
CREATED:20180809T143453Z
LAST-MODIFIED:20191125T194345Z
UID:5422-1535457600-1535463000@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Christian Euler\, a PhD candidate in the laboratory of Professor Krishna Mahadevan\, will give a talk on “Reverse and Forward Engineering: Modelling Real and Synthetic Systems”.  \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up to get more information on upcoming discussion groups\, please contact Laura Prochazka. \n Learn more about Medicine by Design discussion groups\n\n\nAbstract\nOne of the goals of synthetic biology is to recapitulate the dynamics of known biological systems. Modelling these circuits is essential to both explaining how they work and informing the forward design of novel systems with desired dynamic responses to signal inputs. Beyond this\, new dynamic responses may be possible with the rational\, model-driven repurposing of biological parts. In this tutorial\, the basic steps of dynamic modelling will be presented along with several resources to assist you in further exploring model-based design in your synthetic system. All skill levels are welcome and encouraged to attend. 
URL:https://mbd.ccrm.ca/event/synbio-discussion-august-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180619T120000
DTEND;TZID=America/Toronto:20180619T130000
DTSTAMP:20260406T022700
CREATED:20180820T162619Z
LAST-MODIFIED:20191126T153302Z
UID:5701-1529409600-1529413200@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Prisca Liberali\, Friedrich Miescher Institute for Biomedical Research
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Prisca Liberali\, PhD\, from the Friedrich Miescher Institute for Biomedical Research\, affiliated with the University of Basel. The title of her talk is “Self-organization and symmetry breaking in intestinal organoids.” \nDownload poster \nTalk Abstract\nIntestinal organoids are complex three-dimensional structures that mimic cell type composition and tissue organization of the intestine by recapitulating the self-organizing capacity of cell populations derived from a single stem cell. Crucial in this process is a first symmetry-breaking event\, in which only a fraction of identical cells in a symmetrical cyst differentiate into Paneth cells\, which in turn generates the stem cell niche and leads to asymmetric structures such as crypts and villi. We here combine a quantitative single-cell gene expression and imaging approach to characterize the development of intestinal organoids from a single cell. We show that intestinal organoid development follows a regeneration process driven by transient Yap1 activation. Cell-to-cell variability in Yap1\, emerging in symmetrical cysts\, induces a Notch/Dll1 lateral inhibition event driving the symmetry-breaking event and the formation of the first Paneth cell. Our findings reveal how single cells exposed to a uniform growth-promoting environment have the intrinsic ability to generate emergent\, self-organized behavior resulting in the formation of complex multicellular asymmetric structures.
URL:https://mbd.ccrm.ca/event/global-speaker-series-prisca-liberali-june-2018/
LOCATION:Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180515T120000
DTEND;TZID=America/Toronto:20180515T130000
DTSTAMP:20260406T022700
CREATED:20180820T162954Z
LAST-MODIFIED:20191126T152730Z
UID:5703-1526385600-1526389200@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Jared Toettcher\, PhD\, Princeton University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Jared Toettcher\, PhD\, assistant professor of molecular biology at Princeton University. \nDownload event poster \nLivestream talk (link will be live shortly before event) \nPlease check back soon for more details.
URL:https://mbd.ccrm.ca/event/global-speaker-series-jared-toettcher-may-2018/
LOCATION:Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180508T120000
DTEND;TZID=America/Toronto:20180508T130000
DTSTAMP:20260406T022700
CREATED:20180320T215232Z
LAST-MODIFIED:20191125T194345Z
UID:5052-1525780800-1525784400@mbd.ccrm.ca
SUMMARY:Computational Discussion Group
DESCRIPTION:The Computational Discussion Group will meet. For more information about topics and speakers and to register\, please contact Maria Abou Chakra or Himanshu Kaul. This group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/computational-discussion-group-may-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180426T120000
DTEND;TZID=America/Toronto:20180426T130000
DTSTAMP:20260406T022700
CREATED:20180320T214324Z
LAST-MODIFIED:20191125T220911Z
UID:5049-1524744000-1524747600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Michael Levin\, PhD\, Tufts University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Michael Levin\, PhD\, Vannevar Bush Professor in the Department of Biology at Tufts University and director of both the Allen Discovery Center at Tufts University and the Tufts Center for Regenerative and Developmental Biology. His talk title is “Cracking the bioelectric code: Targeting endogenous physiological networks for advances in regenerative medicine and synthetic bioengineering.” \nDownload event poster \nLive stream the talk (link will be live shortly before the talk begins) \nAbstract \nA key property of living tissues is their ability to perform pattern homeostasis: harnessing individual cell behaviours toward creation and repair of complex anatomies during embryogenesis and regeneration. How can the decision-making abilities of cells be targeted for advances in regenerative medicine and synthetic bioengineering? Our group has discovered that an important aspect of information processing at the tissue and organ level occurs via endogenous bioelectrical signalling: spatio-temporal patterns of resting potential (across all cells\, not just neurons) that store and process pattern memories that help direct growth and form. In this talk\, I will explain the basics of non-neural bioelectricity\, illustrate the new molecular techniques we have developed to read and write patterning information into tissues\, and show examples of the control of large-scale pattern by specific modulation of patterns of resting potential. Recent examples include reprogramming of tumours\, converting gut tissue into complete eyes\, induction of appendage regeneration\, innervation control\, and repair of teratogen- and mutation-induced birth defects. While we have identified transduction machinery and transcriptional targets of bioelectric change in single cells\, the biggest open questions concern computationally understanding the dynamics of large-scale bioelectric circuits for pattern control. I will conclude the talk with a perspective on the exciting opportunities in synthesizing machine learning and electroceutical compounds for advances in regenerative repair\, cancer normalization and synthetic morphology. \nBiography \nMike Levin is a professor in the Department of Biology at Tufts University\, holding the endowed Vannevar Bush Chair and serving as director of the Allen Discovery Center at Tufts. He began as a software engineer\, working in scientific programming and artificial intelligence. He then received two B.S. degrees (in computer science and Biology) at Tufts University\, and then went on to a PhD with Cliff Tabin (Harvard Medical School)\, in which they identified the genetic cascade responsible for consistent left-right asymmetry of the embryonic heart and viscera. In his post-doc with Mark Mercola (also at Harvard Medical School)\, he identified a physiological system of long-range signalling upstream of the transcriptional cascades determining embryonic laterality. He started his own group in 2000 at the Forsyth Institute (Harvard School of Dental Medicine)\, focusing on building new molecular tools to read and control the bioelectrically mediated processing of patterning information in embryogenesis and regeneration. He moved his team to the main campus at Tufts in 2009\, to be closer to collaborators in diverse fields. Currently\, his group uses computational and molecular-genetic techniques at the intersection of developmental biophysics\, primitive cognition and machine learning. They use model systems including embryonic frog\, regenerating flatworms\, Physarum slime molds\, and human cells to understand information processing and computation in a wide range of living systems.
URL:https://mbd.ccrm.ca/event/global-speaker-series-michael-levin-april-2018/
LOCATION:Leslie Dan Faculty of Pharmacy\, Room 850\, 144 College Street\, Toronto\, Ontario\, M5S 3M2\, Canada
CATEGORIES:Global Speaker Series
ATTACH;FMTTYPE=image/jpeg:https://mbd.ccrm.ca/wp-content/uploads/2017/09/MBD-Symposium-full-87-720x480.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180410T120000
DTEND;TZID=America/Toronto:20180410T130000
DTSTAMP:20260406T022700
CREATED:20180320T213951Z
LAST-MODIFIED:20191125T194345Z
UID:5047-1523361600-1523365200@mbd.ccrm.ca
SUMMARY:Computational Discussion Group
DESCRIPTION:The Computational Discussion Group will meet. For more information about topics and speakers and to register\, please contact Maria Abou Chakra or Himanshu Kaul. This group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/computational-discussion-group-2018-april/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180327T120000
DTEND;TZID=America/Toronto:20180327T130000
DTSTAMP:20260406T022700
CREATED:20180320T213720Z
LAST-MODIFIED:20191125T194345Z
UID:5045-1522152000-1522155600@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group — Trevor McKee\, PhD
DESCRIPTION:Trevor McKee\, PhD\, will speak on “Moving from Images to Data: Resources and expertise in computational pathology at the STTARR core facility.” \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up to get more information on upcoming discussion groups\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups\n\nTalk abstract \nA major bottleneck in synthetic biology approaches to medicine is the lack of quantitative data on tissue morphology to inform structural information on pathological and healthy tissue states. Excitingly\, the advent of digital pathology with increasing semi-automated computational analysis workflows is moving the discipline towards a quantitative science. Computational pathology is providing new tools that can both augment a clinical pathologist’s toolbox\, as well as provide new insights into tissue structure at single-cell resolution to guide the development of synthetic biology-guided next-generation therapeutics. Single-cell resolution structural and positional information is also a major part of the Human Cell Atlas\, a worldwide consortium to map every cell and cell lineage in the developing and adult human. We are therefore delighted to gain some insight into the work of Dr. Trevor McKee\, visiting from STTARR to talk to us about “Moving from Images to Data: Resources and expertise in computational pathology at the STTARR core facility.” \nDr. McKee is a biological engineer who received his PhD from MIT under the guidance of Dr. Rakesh K. Jain\, on the application of intravital microscopy to studying barriers to drug and gene delivery in tumours. He runs the Computational Pathology core facility within STTARR\, a multi-modality imaging facility within the Princess Margaret Cancer Centre\, where he leads a team of programmers and technicians to build algorithms to quantitatively measure protein and RNA abundance at the single-cell resolution in whole-slide pathology images\, for academic and pharmaceutical clients. \n 
URL:https://mbd.ccrm.ca/event/synbio-discussion-group-march-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180326T123000
DTEND;TZID=America/Toronto:20180326T133000
DTSTAMP:20260406T022700
CREATED:20180820T153115Z
LAST-MODIFIED:20191126T153246Z
UID:5677-1522067400-1522071000@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Eric Siggia\, PhD\, Rockefeller University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Eric Siggia\, PhD\, the Viola Ward Brinning and Elbert Calhoun Brinning Professor at Rockefeller University. The title of his talk is “Microcolonies of Human Embryonic Stem Cells as Models of Early Embryonic Patterning.” \nDownload event poster \nLive stream talk (link will be live shortly before the event)
URL:https://mbd.ccrm.ca/event/global-speaker-series-eric-siggia-march-2018/
LOCATION:Medical Sciences Building\, Room 2170\, 1 King's College Circle\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180220T120000
DTEND;TZID=America/Toronto:20180220T130000
DTSTAMP:20260406T022700
CREATED:20180820T161012Z
LAST-MODIFIED:20191126T153223Z
UID:5689-1519128000-1519131600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Princess Imoukhuede\, PhD\, University of Illinois at Urbana-Champaign
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Princess Imoukhuede\, PhD\, assistant professor of bioengineering at the University of Illinois at Urbana-Champaign. Professor Imoukhuede will deliver a talk on Systems Biology: Recipes for Advancing Predictive Biology. \nDownload event poster \nLive stream talk (link will be live shortly before the event) \nTalk Abstract\nDirected control of angiogenesis can improve the treatment of over 70 diseases. We hypothesize that such control can be reached by computationally integrating two types of parameters: protein concentrations and protein-protein interaction (PPI) kinetics. In support of this hypothesis\, we report three key advancements: (1) engineering of new quantitative fluorescent nanosensors (qFluors) to measure plasma membrane vascular endothelial growth factor receptor (VEGFR) (Fig. 1) and platelet derived growth factor receptor (PDGFR) concentrations and heterogeneity; (2) discovery and measurement of new cross-family interactions between PDGFs and VEGFR2 (Fig. 2); and (3) development of computational models that accurately predict VEGFR-mediated protein phosphorylation\, cell proliferation\, and cell migration (Fig. 3). \nOur approaches are advancing us towards the goal of directing the growth factor receptor signaling that underlies angiogenesis. Firstly\, our qFluors are establishing a new method for quantifying biomarker heterogeneity\, which can be translated to clinical pathology. More immediately\, this approach is providing the receptor concentration data necessary for accurate computational model development. Additionally\, our discovery and measurement of cross-family binding represents a paradigm shift\, where PPI interaction kinetics\, not family\, define our view of protein function. More immediately\, these kinetic measurements provide the necessary data for predicting cell responses. Finally\, our computational models are integrating each of the parameters and providing validated predictions of angiogenic cell response. \nThis material is based upon work supported by the National Science Foundation (NSF)\, American Heart Association (AHA)\, and American Cancer Society (ACS) under Grant #s: NSF CBET: 1512598; NSF CAREER: 1653925; NSF BPE:1648454; AHA:16SDG26940002; and ACS-IL: 282802 \nBiography\nProfessor Imoukhuede earned her SB in Chemical Engineering from the Massachusetts Institute of Technology (MIT) where her research earned her the coveted Class of 1972 award\, presented annually to the project that most improves the quality of life through its impact on people and/or the environment. Professor Imoukhuede’s research was funded by the National Science Foundation’s Biotechnology Process Engineering Center at MIT and through a Bioengineering Undergraduate Research Award by the MIT Division of Bioengineering and Environmental Health.\nProfessor Imoukhuede was honored with the 2002 Betsy Schumaker Award (also known as the MIT female athlete of the year)\, was selected to a COSIDA/VERIZON Academic All-America team\, and was awarded an NCAA postgraduate scholarship. Professor Imoukhuede championed the importance of social responsibility in the midst of academic excellence by serving as the President of the MIT Committee on Multiculturalism\, President of the MIT chapter of the American Institute of Chemical Engineers (AIChE)\, and held both chapter and zone offices in the National Society of Black Engineers (NSBE). \nAfter earning her undergraduate degree\, Professor Imoukhuede pursued graduate study in bioengineering at the California Institute of Technology (Caltech) in Pasadena\, CA. Here\, she combined sensitive techniques in biomedical optics with nanoparticle imaging towards understanding the structure\, function\, and trafficking of a key protein in epilepsy\, the GABA transporter\, GAT1. She also performed research in nicotine addiction through molecular imaging of nicotinic acetylcholine receptors. Professor Imoukhuede’s research in nanotechnology earned her the Kavli Nanoscience Institute Award and her graduate research was supported by the National Institutes of Health (NIDA). Professor Imoukhuede was the first African-American woman to be awarded a Bioengineering PhD by Caltech and was only the second African-American woman to earn a PhD from Caltech’s Division of Engineering and Applied Science. \nProfessor Imoukhuede completed a post-doctoral fellowship in the Biomedical Engineering Department at the Johns Hopkins University School of Medicine.  During her fellowship at Johns Hopkins\, she was 1 of ten post-doctoral fellows nationwide to earn the prestigious United Negro College Fund/Merck Postdoctoral Research Fellowship\, 1 of 6 young investigators to earn the FASEB Postdoctoral Professional Development Award\, and her work was awarded a Poster Award at the biennial Gordon Conference in Angiogenesis. Her post-doctoral work was also supported by the National Institutes of Health (NHLBI).
URL:https://mbd.ccrm.ca/event/global-speaker-series-princess-imoukhuede-february-2018/
LOCATION:Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180116T120000
DTEND;TZID=America/Toronto:20180116T130000
DTSTAMP:20260406T022700
CREATED:20180820T155649Z
LAST-MODIFIED:20191125T194345Z
UID:5683-1516104000-1516107600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Lee Rubin\, PhD\, Harvard University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Lee Rubin\, PhD\, professor in the Department of Stem Cell and Regenerative Biology at Harvard University. This event will be webcast \nBiography\nLee Rubin received his PhD in Neuroscience from The Rockefeller University and completed postdoctoral fellowships in pharmacology at Harvard Medical School and in neurobiology at Stanford University School of Medicine. He has broad experience in both academia and industry\, particularly in the realms of cell-based assays and drug discovery. Prior to Harvard\, he was chief scientific officer of Curis\, Inc.\, a Cambridge-based biotechnology company\, where his group identified the first small molecule regulators of the hedgehog signalling pathway. One of their antagonists was developed by Genentech and is now (as Erivedge) approved as the first oral treatment for metastatic basal cell carcinoma. At Harvard\, much of Rubin’s work is focused on finding key molecular mediators of different neurodegenerative diseases and on searching for effective pre-clinical therapeutic candidates. His group’s research takes advantage of their ability to produce large numbers of patient-derived induced pluripotent stem cell lines and of effective means of deriving large numbers of differentiated neurons from them. They have set up an array of techniques that allow them to identify early cellular and physiological changes in neurons as they become diseased. For example\, they have identified new targets for the treatment of the motor neuron disorders spinal muscular atrophy and amyotrophic lateral sclerosis. They are also studying autism spectrum disorders\, Parkinson’s disease and Alzheimer’s disease. Recently\, his group discovered that a circulating protein\, GDF11\, has the ability to reverse some of the changes in the central nervous system associated with aging. They are actively exploring the therapeutic implications of these observations.
URL:https://mbd.ccrm.ca/event/global-speaker-series-lee-rubin-january-2018/
LOCATION:Canada
CATEGORIES:Global Speaker Series
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