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DTSTART;TZID=America/Toronto:20190826T120000
DTEND;TZID=America/Toronto:20190826T140000
DTSTAMP:20260406T004853
CREATED:20190514T203615Z
LAST-MODIFIED:20191125T194315Z
UID:6622-1566820800-1566828000@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:This group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact the group organizers. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-august-2019/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190730T120000
DTEND;TZID=America/Toronto:20190730T130000
DTSTAMP:20260406T004853
CREATED:20190226T210558Z
LAST-MODIFIED:20191125T194315Z
UID:6458-1564488000-1564491600@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Jenise Chen\, a PhD candidate in the Kelley lab\, will give a talk titled “A multiplexed\, electrochemical interface for cell-free synthetic toehold-mediated gene networks”. \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups\n\nTalk abstract\nThe implementation of colorimetric detection techniques has offered a powerful means of producing rapid qualitative results with easy visual readout. However\, these techniques are usually limited to either a “yes” or “no” answer and have difficulty multiplexing over three targets simultaneously. Electrochemical detection is capable of providing solutions to these limitations. The key advantage of electrochemical assays is the ability for signal amplification\, allowing for trace analyte detection. Recent literature has highlighted the promising avenues of synthetic biology and cell-free gene circuits. This project is the first of its kind to detect cell-free synthetic gene circuits through electrochemical readout. A gold-based electrochemical sensor has been designed to implement five different detection sites for restriction enzyme cutting of surface-immobilized DNA labelled with methylene blue. Restriction enzymes are produced through a cell-free toehold gene circuit and are easily redesigned for disease-specific detection. By coupling electrochemical detection and cell-free toehold gene circuits\, we were able to create a multiplexed assay for applications in antibiotics and antibiotic resistance detection.
URL:https://mbd.ccrm.ca/event/synbio-discussion-group-2019-july/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190729T120000
DTEND;TZID=America/Toronto:20190729T140000
DTSTAMP:20260406T004853
CREATED:20190514T203428Z
LAST-MODIFIED:20191125T194316Z
UID:6620-1564401600-1564408800@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:This group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact the group organizers. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-july-2019/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190723T110000
DTEND;TZID=America/Toronto:20190723T120000
DTSTAMP:20260406T004853
CREATED:20190716T183334Z
LAST-MODIFIED:20191125T194316Z
UID:6804-1563879600-1563883200@mbd.ccrm.ca
SUMMARY:Translational Biology & Engineering Program Research Seminar: Shulamit Levenberg\, PhD\, Technion
DESCRIPTION:Professor Shulamit Levenberg\, PhD\, Dean of the Faculty of Biomedical Engineering at Technion-Israel Institute of Technology will give a talk titled “Engineered vascularized tissue constructs.” \n\nLearn more
URL:https://mbd.ccrm.ca/event/translational-biology-engineering-program-research-seminar-shulamit-levenberg-phd-technion/
LOCATION:Ted Rogers Centre for Heart Research\, 661 University Avenue\, 14th Floor\, Toronto\, Ontario\, M5G 1M1\, Canada
CATEGORIES:Other Events
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190718T120000
DTEND;TZID=America/Toronto:20190718T130000
DTSTAMP:20260406T004853
CREATED:20190610T150117Z
LAST-MODIFIED:20191126T154434Z
UID:6713-1563451200-1563454800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Shulamit Levenberg\, PhD — Technion-Israel Institute of Technology
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Shulamit Levenberg\, PhD\, Dean of the Faculty of Biomedical Engineering at Technion-Israel Institute of Technology and the inaugural Medicine by Design Scholar in Residence. The title of her talk is “Vascularization Dynamics in Engineered Tissues.” \n\nDownload event poster\n\nBiography\nProfessor Shulamit Levenberg is the elected Dean of the Biomedical Engineering Department at the Technion. She also serves as the director of the Technion Center for 3D Bioprinting and The Rina & Avner Schneur Center for Diabetes Research. Professor Levenberg earned her PhD at the Weizmann Institute of Science\, where she focused on cell adhesion dynamics and signaling\, and pursued her post-doctoral research in tissue engineering at MIT\, in the lab of Professor Robert Langer. In 2004\, she joined the Technion Faculty of Biomedical Engineering where she conducts interdisciplinary research on stem cells and tissue engineering. She spent a sabbatical year (2011-2012) as a visiting professor at the Wyss Institute for Biology Inspired Engineering at Harvard University and a summer sabbatical (2017) at the University of Western Australia as a winner of the Raine Visiting Professor Award. Professor Levenberg received the Krill Prize for excellence in scientific research\, awarded by the Wolf Foundation\, and was named by Scientific American as a “Research Leader” in tissue engineering\, for her seminal work on vascularization of engineered tissues. She also received the France-Israel Foundation Prize\, the Italian Excellence for Israel Prize\, the Teva Research Prize and the Juludan Prize. In 2018\, she received the Rappaport Prize for Biomedical Sciences. Professor Levenberg has authored more than 100 publications\, and presented her work in over 100 international conferences as an invited or keynote speaker. She is founder and chief scientific officer of two start-up companies in the areas of cultured meat and nanoliter arrays for rapid antimicrobial susceptibility testing.  She is a member of the Israel National Counsel for Bioethics and is actively involved in training young scientists.
URL:https://mbd.ccrm.ca/event/global-speaker-series-shulamit-levenberg-july-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190706T080000
DTEND;TZID=America/Toronto:20190721T170000
DTSTAMP:20260406T004853
CREATED:20190628T182304Z
LAST-MODIFIED:20191125T194316Z
UID:6748-1562400000-1563728400@mbd.ccrm.ca
SUMMARY:Summer by Design
DESCRIPTION:How do you move innovative regenerative medicine discoveries out of the lab efficiently and effectively so patients benefit sooner? \nMedicine by Design\, in partnership with CCRM and the Rotman School of Management\, hosts a two-week workshop each summer for high-performing PhD candidates and post-doctoral fellows from around the world to advance their understanding of how to translate and commercialize regenerative medicine research. The workshop takes place in Toronto\, Canada\, where stem cells were first discovered in the 1960s and a leading regenerative medicine ecosystem has developed. \nSummer by Design brings together trainees from selected international regenerative medicine institutes and the University of Toronto and its affiliated hospitals to learn from experts in clinical translation and commercialization\, explore the city’s dynamic life sciences hub\, and make connections with emerging researchers from around the world.
URL:https://mbd.ccrm.ca/event/summer-by-design/
CATEGORIES:Workshops
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190624T120000
DTEND;TZID=America/Toronto:20190624T140000
DTSTAMP:20260406T004853
CREATED:20190514T203259Z
LAST-MODIFIED:20191125T194316Z
UID:6618-1561377600-1561384800@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:This group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact the group organizers. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-2/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190618T120000
DTEND;TZID=America/Toronto:20190618T130000
DTSTAMP:20260406T004853
CREATED:20190510T164043Z
LAST-MODIFIED:20191126T154411Z
UID:6590-1560859200-1560862800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Kevin Chalut\, PhD — University of Cambridge
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Kevin Chalut\, PhD\, a Royal Society University Research Fellow\, Cavendish Laboratory\, at the University of Cambridge and principal investigator in the Cambridge Stem Cell Institute. He will give a talk titled\, “Mechanical signalling and cell fate.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\n  \nTalk Abstract\nThe role of mechanical signaling in cell fate choice has been largely overlooked; however\, it plays a significant role in tuning cellular response to signals. My lab is investigating the interplay between biochemical signaling and mechanical signaling in cell fate decisions. I will show first in the mouse embryo that biochemical signaling modulates cytoskeletal contractility to influence spatial positioning and solidify cell fate choice. I will then show that mechanics tunes the response of the cell to biochemical signaling to steer fate choice. This hypothetical feedback loop between mechanics and biochemical signaling likely has significant impact on cellular plasticity both in development and stem cells. I will also present an example demonstrating the functional impact of mechanics on stem cell function. In this example\, we have shown that we can reverse the loss of plasticity associated with ageing by controlling the mechanical microenvironment. Ultimately\, I will advance the hypothesis that mechanical sensing acts as a switch to modulate growth factor signaling to modulate cell fate choice. \n  \nBiography\nKevin Chalut is a biophysicist with a PhD in Physics from Duke University. He is currently a group leader at the Wellcome Trust-Medical Research Council Stem Cell Institute in Cambridge. \nHis work focuses on using the tools and concepts of physics to study cell fate choice in stem cells and developing organisms. His lab primarily investigates how the mechanical microenvironment regulates fate decisions\, and exactly how cells process information during that fate choice. The ultimate goal of his laboratory is to apply their physics-based techniques to understand how organisms develop\, and also how to use stem cells for therapeutic use.
URL:https://mbd.ccrm.ca/event/global-speaker-series-kevin-chalut-june-2019/
LOCATION:Medical Sciences Building\, Room 2172\, 1 King's College Circle\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190603T120000
DTEND;TZID=America/Toronto:20190603T130000
DTSTAMP:20260406T004853
CREATED:20181210T171351Z
LAST-MODIFIED:20200429T165518Z
UID:6162-1559563200-1559566800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Daniel G. Anderson\, PhD - Massachusetts Institute of Technology
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Daniel G. Anderson\, PhD\, the Samuel A. Goldblith Professor of Applied Biology\, associate professor in the Department of Chemical Engineering and Institute for Medical Engineering and Science\, and a member of the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology. He will give a talk titled\, “Delivery systems for in vivo genome editing and cell therapy.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\nTalk Abstract\nHigh throughput\, combinatorial approaches have revolutionized small molecule drug discovery.  Here we describe our work on the combinatorial development of biomaterials for medical devices ranging from nanoparticulate delivery systems to macroscopic devices.  One focus of our work is on nanoparticulate\, intracellular delivery systems for RNA therapy and gene editing.  Libraries of degradable polymers and lipid-like materials have been synthesized\, formulated and screened for their ability to delivery macromolecular payloads inside of cells.  A number of delivery formulations have been developed with in vivo efficacy\, enabling gene suppression with siRNA\, gene expression with mRNA\, or permanent genetic editing using the CRISPR/Cas9 system.  These formulations show potential therapeutic application for the treatment of disease in both rodent and primate models.  A second focus of our work is on developing biomaterials that can avoid the fibrotic response common to implanted medical devices.  Using combinatorial chemistry\, we have developed new materials capable of avoiding fibrosis and scar tissue formation. These show particular promise as vehicles for the immune-isolation of transplanted cells\, for the treatment of diabetes.  When formulated into microcapsules these materials enable functional\, long-term islet transplantation in immune competent\, diabetic rodents\, as well as normal non-human primates. \nBiography\nLearn more about Daniel G. Anderson
URL:https://mbd.ccrm.ca/event/global-speaker-series-daniel-anderson-june-2019/
LOCATION:Medical Sciences Building\, Room 2172\, 1 King's College Circle\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190528T120000
DTEND;TZID=America/Toronto:20190528T140000
DTSTAMP:20260406T004853
CREATED:20190514T201412Z
LAST-MODIFIED:20191125T194316Z
UID:6614-1559044800-1559052000@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:This meeting will feature two speakers \n\nChristine Nguyen (Stewart lab): “Characterizing the electrophysiological properties of 3D bioengineered skeletal muscle”\nBella Xu (Gilbert lab): “An in vitro functional assay to predict in vivo muscle stem cell engraftment outcomes – faster\, cheaper and easier”\n\nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact the group organizers. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-may-2019/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190528T120000
DTEND;TZID=America/Toronto:20190528T130000
DTSTAMP:20260406T004853
CREATED:20190226T210212Z
LAST-MODIFIED:20191125T194316Z
UID:6456-1559044800-1559048400@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Michael Garton\, an assistant professor at the Institute of Biomaterials & Biomedical Engineering\, will give a talk titled “Bringing protein interface design to the synthetic biology party”. \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/synbio-discussion-group-2019-may/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190507T120000
DTEND;TZID=America/Toronto:20190507T130000
DTSTAMP:20260406T004853
CREATED:20181210T170927Z
LAST-MODIFIED:20191126T153836Z
UID:6160-1557230400-1557234000@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Abhay Pandit\, PhD - National University of Ireland Galway
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Abhay Pandit\, PhD\, established professor in biomaterials at the National University of Ireland Galway. He will give a talk titled\, “Redefining Identity of Disease\, Tissues and Cells: A Biomaterials Paradigm.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\nLearn more about Abhay Pandit
URL:https://mbd.ccrm.ca/event/global-speaker-series-may-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190430T120000
DTEND;TZID=America/Toronto:20190430T130000
DTSTAMP:20260406T004853
CREATED:20190226T205829Z
LAST-MODIFIED:20191125T194331Z
UID:6454-1556625600-1556629200@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Lyla El-Fayoumi\, a MSc candidate in the van der Kooy lab\, will give a talk titled “Science at the Speed of Light: Optogenetics 101”. \nLyla El-Fayomi is working with in vivo optogenetic tools to study the neural circuits involved in drug addiction. She will discuss with us the opportunities and challenges presented by optogenetics and introduce her newly-created optogenetics working group that is going to focus on discussing methods and troubleshooting protocols. \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/synbio-discussion-group-2019-april/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190429T120000
DTEND;TZID=America/Toronto:20190429T140000
DTSTAMP:20260406T004853
CREATED:20190426T200220Z
LAST-MODIFIED:20191125T194331Z
UID:6570-1556539200-1556546400@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:This meeting will feature two speakers \n\nEge Sarikaya — “Understanding the disease pathogenesis of X-linked myotubular myopathy”\nLily Huang — “Investigating the role of VMA21in relation to autophagy and myopathy with excessive autophagy (MEA)”\n\nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Louise Moyle. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190423T120000
DTEND;TZID=America/Toronto:20190423T130000
DTSTAMP:20260406T004853
CREATED:20181210T165302Z
LAST-MODIFIED:20191126T153901Z
UID:6157-1556020800-1556024400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Cole DeForest\, PhD - University of Washington
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Cole DeForest\, PhD\, an assistant professor in the Department of Chemical Engineering and core faculty at the Institute of Stem Cell & Regenerative Medicine at the University of Washington. He will give a talk titled\, “User-Programmable Hydrogel Biomaterials to Probe and Direct 4D Stem Cell Fate.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\nTalk Abstract\nThe extracellular matrix directs stem cell function through a complex choreography of biomacromolecular interactions in a tissue-dependent manner. Far from static\, this hierarchical milieu of biochemical and biophysical cues presented within the native cellular niche is both spatially complex and ever changing. As these pericellular reconfigurations are vital for tissue morphogenesis\, disease regulation\, and healing\, in vitro culture platforms that recapitulate such dynamic environmental phenomena would be invaluable for fundamental studies in stem cell biology\, as well as in the eventual engineering of functional human tissue. In this talk\, I will discuss some of our group’s recent success in reversibly modifying both the chemical and physical aspects of synthetic cell culture platforms with user-defined spatiotemporal control. Results will highlight our ability to modulate intricate cellular behavior including stem cell differentiation\, protein secretion\, and cell-cell interactions in 4D. \nBiography\nLearn more about Cole DeForest
URL:https://mbd.ccrm.ca/event/global-speaker-series-cole-deforest-april-2019/
LOCATION:Mount Sinai Hospital\, Ben Sadowski Auditorium\, 18th floor\, 600 University Avenue\, Toronto\, Ontario\, M5G 1X5\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190401T150000
DTEND;TZID=America/Toronto:20190401T160000
DTSTAMP:20260406T004853
CREATED:20190329T205705Z
LAST-MODIFIED:20191126T154243Z
UID:6521-1554130800-1554134400@mbd.ccrm.ca
SUMMARY:Special Seminar: Dr. Timothy O'Brien\, National University of Ireland\, Galway
DESCRIPTION:Timothy O’Brien\, MD\, PhD will give a talk titled “Therapeutic Potential of Mesenchymal Stem Cells for Diabetic Complications: Translational Pathway in the EU.” \n\nDownload poster\n\nAbstract\nDiabetes mellitus is assuming pandemic proportions and is associated with microvascular and macrovascular complications which result in major morbidity and mortality. These conditions represent unmet medical need and new treatment approaches are needed. My laboratory is interested in the use of mesenchymal stromal cells to treat diabetic complications as they are readily isolated\, can be culture expanded under GMP conditions and possess anti-inflammatory\, immunomodulatory and angiogenic properties. We are particularly interested in the translation of laboratory discoveries to the clinic and to this end have constructed specialized GMP and clinical research facilities. The presentation will describe the translational pathway\, with an emphasis on regulatory issues\, in progressing from the laboratory to early phase clinical trials. Pre-clinical and early clinical trial experience of the use of MSCs in diabetic macrovascular and microvascular disease will be presented. Advances in cell manufacture will also be described. \nBiography\nDr. O’Brien is Professor of Medicine and Director of the Regenerative Medicine Institute\, National University of Ireland Galway. He is also a Consultant Physician in Endocrinology and Metabolism\, Saolta University Healthcare Group\, Ireland.
URL:https://mbd.ccrm.ca/event/special-seminar-dr-timothy-obrien-national-university-of-ireland-galway/
LOCATION:Ted Rogers Centre for Heart Research\, 661 University Avenue\, 14th Floor\, Toronto\, Ontario\, M5G 1M1\, Canada
CATEGORIES:Other Events
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190326T120000
DTEND;TZID=America/Toronto:20190326T130000
DTSTAMP:20260406T004853
CREATED:20190226T205147Z
LAST-MODIFIED:20191125T194331Z
UID:6451-1553601600-1553605200@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Leo Chou\, an assistant professor at the Institute of Biomaterials & Biomedical Engineering\, will give a talk titled “What can DNA nanotechnology do for synthetic biology?” \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups\n\nTalk Abstract\nThe field of DNA nanotechnology uses nucleic acids as a “brick & mortar” toolset to build synthetic molecular structures and devices. These DNA-based tools leverage the sequence-programmability and predictability of nucleic acid hybridization to enable precise spatiotemporal manipulation of macromolecules as well as higher-ordered assemblies. A central motivation of the field is to be able to design and create artificial molecular assemblies that rival the complexity of natural molecular systems\, and that can perform user-defined tasks across molecular to cellular length scales. The pursuit of this goal also aims to contribute towards a bottom-up understanding of how the spatiotemporal dynamics of biomolecular assemblies dictate their function\, which can inform synthetic biology design. \nIn this talk I will provide an overview of DNA nanotechnology and briefly introduce its fundamental as well as emerging capabilities. I will highlight existing examples of DNA-based molecular tools and devices\, including their use for synthetic biology applications\, such as for controlling receptor signaling and gene expression. I will also highlight efforts from our own group to engineer bio-inspired molecular devices for applications in biological sensing and therapeutic discovery.
URL:https://mbd.ccrm.ca/event/synbio-discussion-group-2019-march/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190318T120000
DTEND;TZID=America/Toronto:20190318T130000
DTSTAMP:20260406T004853
CREATED:20181220T172601Z
LAST-MODIFIED:20191125T194331Z
UID:6236-1552910400-1552914000@mbd.ccrm.ca
SUMMARY:Career Speaker Series: Alborz Mahdavi\, Protomer Technologies
DESCRIPTION:Learn more and register
URL:https://mbd.ccrm.ca/event/career-speaker-series-alborz-mahdavi-protomer-technologies/
CATEGORIES:Career Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190313T083000
DTEND;TZID=America/Toronto:20190315T171500
DTSTAMP:20260406T004853
CREATED:20190227T145007Z
LAST-MODIFIED:20191125T194331Z
UID:6474-1552465800-1552670100@mbd.ccrm.ca
SUMMARY:Cell & Gene Therapy Revolution: Pan-Canadian Strategic Forum
DESCRIPTION:Following the success of its first edition\, CellCAN is happy to announce that the second pan-Canadian Strategic Forum will be held this winter\, on March 13-15\, 2019\, in Toronto. \nIn partnership with the Centre for Commercialization of Cancer Immunotherapy (C3i) and the Centre for Commercialization of Regenerative Medicine (CCRM)\, this Strategic Forum represents a great opportunity to identify concrete actions – from manufacturing to commercialization – that can be taken to help stakeholders in our field become better equipped to develop cell\, tissue and gene therapies. \n\nLearn more and register
URL:https://mbd.ccrm.ca/event/cellcan-forum-2019-march/
LOCATION:The Omni King Edward Hotel\, 37 King Street East\, Toronto\, Ontario\, M5C 1E9\, Canada
CATEGORIES:External Events
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190307T123000
DTEND;TZID=America/Toronto:20190307T133000
DTSTAMP:20260406T004853
CREATED:20181210T164335Z
LAST-MODIFIED:20191126T153958Z
UID:6154-1551961800-1551965400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Weian Zhao\, PhD - University of California\, Irvine
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Weian Zhao\, PhD\, associate professor at the Sue and Bill Gross Stem Cell Research Center\, Chao Family Comprehensive Cancer Center\, and Department of Pharmaceutical Sciences at the University of California\, Irvine. He will give a talk titled\, “Bioengineering technologies for next generation stem cells and immunotherapies.” \n Download event poster \n This event will be livestreamed (link will be live shortly before event) \nLearn more about Weian Zhao
URL:https://mbd.ccrm.ca/event/global-speaker-series-weian-zhao-march-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190228T120000
DTEND;TZID=America/Toronto:20190228T130000
DTSTAMP:20260406T004853
CREATED:20181220T172404Z
LAST-MODIFIED:20191125T194331Z
UID:6234-1551355200-1551358800@mbd.ccrm.ca
SUMMARY:Career Speaker Series: Omar F. Khan\, Tiba Biotech\, LLC
DESCRIPTION:Learn more and register
URL:https://mbd.ccrm.ca/event/career-speaker-series-omar-f-khan/
CATEGORIES:Career Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190122T120000
DTEND;TZID=America/Toronto:20190122T130000
DTSTAMP:20260406T004853
CREATED:20181210T163443Z
LAST-MODIFIED:20191126T154151Z
UID:6151-1548158400-1548162000@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Peter Reddien\, PhD - Massachusetts Institute of Technology
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Peter Reddien\, PhD\, a professor in the Department of Biology at the Massachusetts Institute of Technology. He will give a talk titled\, “The essential components of regeneration.” \nDownload event poster \nThis event will be livestreamed (link will be live shortly before event) \nTalk Abstract\nHow animals regenerate missing body parts is one of the great mysteries of biology. Planarians are flatworms capable of some of the most dramatic known feats of animal regeneration\, including regeneration of new heads. We have uncovered a key set of minimal components and concepts needed to explain how these animals accomplish their regenerative feats. \nBiography\nLearn more about Peter Reddien
URL:https://mbd.ccrm.ca/event/global-speaker-series-peter-reddien-january-2019/
LOCATION:Mount Sinai Hospital\, Ben Sadowski Auditorium\, 18th floor\, 600 University Avenue\, Toronto\, Ontario\, M5G 1X5\, Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190121T150000
DTEND;TZID=America/Toronto:20190121T160000
DTSTAMP:20260406T004853
CREATED:20190116T151320Z
LAST-MODIFIED:20191125T194331Z
UID:6332-1548082800-1548086400@mbd.ccrm.ca
SUMMARY:Special Seminar: Kaitlyn Sadtler\, PhD
DESCRIPTION:The Institute of Biomaterials & Biomedical Engineering and Medicine by Design present a special seminar by Kaitlyn Sadtler\, PhD. The title of her talk is “Harnessing the Immune System in Regenerative Medicine.” Learn more
URL:https://mbd.ccrm.ca/event/special-seminar-kaitlyn-sadtler-phd/
LOCATION:Canada
CATEGORIES:Other Events
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190111T120000
DTEND;TZID=America/Toronto:20190111T130000
DTSTAMP:20260406T004853
CREATED:20181220T172129Z
LAST-MODIFIED:20191125T194331Z
UID:6231-1547208000-1547211600@mbd.ccrm.ca
SUMMARY:Career Speaker Series: Azadeh Golipour\, AVROBIO\, Inc.
DESCRIPTION:Learn more and register
URL:https://mbd.ccrm.ca/event/career-speaker-series-azadeh-golipour-avrobio-inc/
CATEGORIES:Career Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181211T120000
DTEND;TZID=America/Toronto:20181211T133000
DTSTAMP:20260406T004853
CREATED:20180820T142558Z
LAST-MODIFIED:20191125T194331Z
UID:5658-1544529600-1544535000@mbd.ccrm.ca
SUMMARY:Computational Biology Discussion Group
DESCRIPTION:Professor Rudi Winklbauer from the Department of Cell & Systems Biology will give a talk titled “Adhesion mechanisms for a vast range of cell adhesion strengths.” \nFor more information about topics and speakers and to register\, please contact Maria Abou Chakra or Himanshu Kaul. This group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n Learn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/compbio-discussion-december-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181204T080000
DTEND;TZID=America/Toronto:20181204T171500
DTSTAMP:20260406T004853
CREATED:20180814T223719Z
LAST-MODIFIED:20191126T153340Z
UID:5567-1543910400-1543943700@mbd.ccrm.ca
SUMMARY:Medicine by Design Symposium
DESCRIPTION:REGISTRATION IS CLOSED – WE HAVE REACHED CAPACITY\nTHE DEADLINE TO SUBMIT POSTER ABSTRACTS WAS OCT. 10. WE ARE NO LONGER ACCEPTING POSTER ABSTRACTS.\nCell and Gene Therapy\n\nThe third annual Medicine by Design Symposium will bring together principal investigators and trainees from across the University of Toronto and affiliated hospitals\, along with members of our Scientific Advisory Board\, to share research and ignite new collaborations. Session themes include: \n\nGene engineering\nImmune engineering\nMuscle engineering\nNeural engineering\n\nThe symposium will also include an opportunity for trainees in Medicine by Design-funded labs to present their research during a poster session. \n\nInvited Speakers\n \n\n\nRegistration\nREGISTRATION HAS CLOSED \n\nAgenda and Poster List\nAgenda – FINAL \nPoster Index \n\nFlyer\nDownload the symposium flyer
URL:https://mbd.ccrm.ca/event/symposium-2018/
LOCATION:101 College Street\, Toronto\, Ontario\, M5G 1L7\, Canada
CATEGORIES:Symposium
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181127T120000
DTEND;TZID=America/Toronto:20181127T133000
DTSTAMP:20260406T004853
CREATED:20180814T221947Z
LAST-MODIFIED:20191125T194331Z
UID:5565-1543320000-1543325400@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Keith Pardee\, an assistant professor at the Leslie Dan Faculty of Pharmacy\, will give a talk on “Cell-free Synthetic Biology:  Rapid\, Low-cost Tools for Human Health.” \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and received information about upcoming meetings\, please contact Laura Prochazka. \nTalk Abstract\nWe see cell-free technologies as important tools in meeting challenges that face health care systems at home and abroad.  As we have demonstrated\, cell-free hosting of diagnostics and drug manufacturing offers a paradigm shift in how health care systems can adapt rapidly to public health needs\, provide emergency response and extend lab-grade molecular capabilities into virtually any environment.  Such applications are enabled by freeze-dried cell-free (FD-CF) enzymes that are sterile yet retain the properties of cellular transcription and translation for deploying poised molecular components to the field.  \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/synbio-discussion-november-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181120T120000
DTEND;TZID=America/Toronto:20181120T130000
DTSTAMP:20260406T004853
CREATED:20180820T150235Z
LAST-MODIFIED:20191126T153521Z
UID:5670-1542715200-1542718800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Marlene Rabinovitch\, MD\, Stanford University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Marlene Rabinovitch\, MD\, the Dwight and Vera Dunlevie Professor in Pediatric Cardiology at Stanford University. She will give a talk titled\, “Impact of shear stress on chromatin accessibility and gene regulation.” \nDownload poster \nThis talk will be be live streamed \nTalk Abstract\nIt is well known that laminar shear stress as opposed to static or disturbed flow induces vasculoprotective endothelial (EC) genes such as endothelial nitric oxide synthase (eNOS)\, but how changes in flow affect chromatin accessibility at specific transcription factor binding sites is not known. We used the Ibidi flow system with cultured pulmonary arterial (PA) EC and applied ATAC Seq\, ChIPSeq and RNA Seq to determine why certain regions of chromatin open and others close to regulate a distinct program of gene expression. We determined by mass spectrometry and proximity ligation analysis that KLF4 interacts with the Brg complex of chromatin remodelers under laminar flow to regulate genes that protect endothelial cells and that ATF2 interacts with the Brg complex of chromatin remodelers under static or disturbed flow\, to regulate genes that can perturb endothelial function and lead to a pro-inflammatory milieu. We harvested EC from patients with pulmonary arterial hypertension (PAH) associated with a congenital heart defect but could not observe a phenotype that distinguished these from control EC under static or laminar flow conditions.  Based upon computer modeling of a congenital heart defect with PAH\, we subjected the EC to high shear\, 100 or 170 dynes cm2.  In both cases we saw evidence of high eNOS and eNOS un-coupling resulting in an increase in reactive oxygen species (ROS). RNA sequencing revealed increased cholesterol biosynthesis and activation of GTPase that can alter caveoli and result in eNOS uncoupling\, ROS production and perturbation of normal endothelial cell function. \nBiography\nDr. Rabinovitch is the Dwight and Vera Dunlevie Professor in Pediatric Cardiology\, at Stanford University School of Medicine. Dr. Rabinovitch graduated from McGill University Medical School and completed her pediatrics training at the University of Colorado and sub-specialty training in cardiology at Boston Children’s Hospital\, Harvard Medical School\, where she was Assistant Professor. She then became Professor of Pediatrics\, Laboratory Medicine and Pathobiology and Medicine at the University of Toronto\, Director of the Cardiovascular Research Program at the Hospital for Sick Children and the Robert M. Freedom/Heart and Stroke Foundation Chair. \nDr. Rabinovitch has received numerous awards for her research and mentoring. These include: \n\n2017: the American Heart Association Distinguished Scientist Lecturer;\n2016: the prestigious J. Burns Amberson Lectureship from the American Thoracic Society\, and the Robert F. Grover Prize from the Assembly on Pulmonary Circulation;\n2015: Mentorship Awards from the Association for Women in Science and the Stanford Department of Pediatrics;\n2012: the Judith Pool Mentorship Award;\n2010: the Louis and Artur Lucian Award for Research in Circulatory Diseases from McGill University:\n2008: the Recognition Award for Scientific Accomplishment from ATS;\n2006: the American Heart Association’s (AHA) Distinguished Scientist Award;\n2004: AHA’s Basic Research Prize\, and the Canadian Institute of Circulatory and Respiratory Health Lectureship and Prize; and\n2003: the Gill Heart Institute Award for Outstanding Contributions to Cardiovascular Research.\n\nShe has given numerous named lectureships\, including the AHA Paul Dudley White and Dickinson Richards Lectures\, as well as the American Physiological Society Julius Comroe Lecture. She has served as Visiting Professor in many countries worldwide and has over 190 peer-reviewed publications and 124 invited reviews and book chapters. \nDr. Rabinovitch is currently the Director of the Basic Science and Engineering Initiative of the Betty Irene Moore Children’s Heart Center at Stanford University. In addition\, she is the Associate Director in Basic Research at Stanford’s Cardiovascular Institute and on the Executive Committee of the Pulmonary Vascular Research Institute. She has recently served as an External Advisor to the NHLBI Lung Regeneration Program\, the Max Planck Institute for Heart and Lung Research and the German Lung Centers of Excellence\, and has also served on the Scientific Advisory Councils of NHLBI as well as numerous other Research Foundations. She is a member of the American Society for Clinical Investigation\, and the Association of American Physicians\, and has been Associate Editor of Circulation Research and Annual Reviews of Physiology. Her research focuses on uncovering fundamental genetic\, metabolic\, and inflammatory mechanisms causing pulmonary hypertension that can be translated to the clinic.
URL:https://mbd.ccrm.ca/event/global-speaker-series-marlene-rabinovitch-november-2018/
LOCATION:Mount Sinai Hospital\, Ben Sadowski Auditorium\, 18th floor\, 600 University Avenue\, Toronto\, Ontario\, M5G 1X5\, Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181113T120000
DTEND;TZID=America/Toronto:20181113T133000
DTSTAMP:20260406T004853
CREATED:20180820T142410Z
LAST-MODIFIED:20191125T194332Z
UID:5656-1542110400-1542115800@mbd.ccrm.ca
SUMMARY:Computational Biology Discussion Group
DESCRIPTION:The Computational Biology Discussion Group will meet. For more information about topics and speakers and to register\, please contact Maria Abou Chakra or Himanshu Kaul. This group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n Learn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/compbio-discussion-november-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181030T120000
DTEND;TZID=America/Toronto:20181030T133000
DTSTAMP:20260406T004853
CREATED:20180814T221116Z
LAST-MODIFIED:20191125T194332Z
UID:5561-1540900800-1540906200@mbd.ccrm.ca
SUMMARY:Computational and Synthetic Biology Discussion Groups
DESCRIPTION:Kaushik Raj\, a PhD candidate in the laboratory of Professor Krishna Mahadevan (Department of Chemical Engineering & Applied Chemistry)\, will give a talk on “Emergent properties in gene regulation”. \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. \nTalk Abstract\nThis talk will focus on how simple motifs in gene regulatory networks come together to result in complex regulatory programs\, and how mathematical models can help us study them. A special emphasis will be given to modelling and engineering bistability in biological systems. \nLearn more about Medicine by Design discussion groups\n\n 
URL:https://mbd.ccrm.ca/event/joint-discussion-october-2018-2/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
END:VCALENDAR