BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Medicine by Design - ECPv6.16.5//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Medicine by Design X-ORIGINAL-URL:https://mbd.ccrm.ca X-WR-CALDESC:Events for Medicine by Design REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:America/Toronto BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20220313T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20221106T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20230312T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20231105T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20240310T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20241103T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20250309T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20251102T060000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:-0500 TZOFFSETTO:-0400 TZNAME:EDT DTSTART:20260308T070000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:-0400 TZOFFSETTO:-0500 TZNAME:EST DTSTART:20261101T060000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;VALUE=DATE:20250602 DTEND;VALUE=DATE:20250612 DTSTAMP:20250325T190740Z CREATED:20250325T190740Z LAST-MODIFIED:20250325T190740Z UID:35240-1748822400-1749686399@mbd.ccrm.ca SUMMARY:Summer by Design 2025 DESCRIPTION:How do you move innovative discoveries out of the lab efficiently and effectively so patients benefit sooner? What are the steps involved in translating and commercializing regenerative medicine discoveries? What career opportunities exist beyond academia? \nSummer by Design is an intensive program for PhD students and post-doctoral fellows from Canadian and international universities that will run from June 10 to 19\, 2024\, at the University of Toronto. \nThis eight-day program will feature expert-led\, interactive sessions including lectures\, group work and case studies. \nParticipants will: \n\nMake connections with international peers\nExplore Toronto’s dynamic life sciences hub by meeting with clinical and industry leaders in regenerative medicine\nMeet and collaborate with other Summer by Design participants\, a diverse group of international peers\n\nLearn more about Summer by Design. \n  URL:https://mbd.ccrm.ca/event/summer-by-design-2025/ CATEGORIES:Partner Events END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20250508T150000 DTEND;TZID=America/Toronto:20250508T170000 DTSTAMP:20250403T161618Z CREATED:20250325T184952Z LAST-MODIFIED:20250403T161618Z UID:35227-1746716400-1746723600@mbd.ccrm.ca SUMMARY:Building a Biotech Venture Pitch Competition DESCRIPTION:Register now\n \n  \nJoin us in-person for the Building a Biotech Venture Pitch Competition\, where the next generation of regenerative and precision medicine innovators will showcase their entrepreneurial vision. \nSix trainee-led teams from the University of Toronto and its affiliated hospitals will pitch their cutting-edge ventures to an expert panel of judges. The winning team will receive $25\,000 in research funding to propel their technology toward real-world impact. \nThis year\, the program is led by the PRiME Next-Generation Precision Medicine in close partnership with Medicine by Design\, Health Innovation Hub (H2i) and Talk Boutique. \nOver the past months\, teams have worked with mentors to advance early-stage company concepts based on their research and have participated in a series of workshops to develop their business cases. \nThis competition represents the culmination of their journey\, where ground-breaking research meets commercialization. \nCome support these up-and-coming entrepreneurs as they take the stage to drive the future of biotechnology! \n  \nMeet the Finalist Teams\n\nA2O\nReprogramming for brain recovery \nMany central nervous system diseases are characterized by a loss of oligodendrocytes\, the cells that enable fast and efficient communication in the brain\, as well as dysfunction of astrocytes. A2O has developed a platform gene therapy technology to generate new oligodendrocytes by reprogramming these dysfunctional astrocytes – a two birds with one stone approach to brain repair. \nTeam members: Maryam Faiz\, Justine Bajohr \n\nBoutIQ Solutions Inc. \nBoutIQ Solutions Inc. leverages AI/ML-driven optimization to revolutionize cell culture media. Our cutting-edge approach enables the rapid development of complex\, custom formulations. We are pioneering next-generation\, chemically defined media that enhances physiological function and maturity\, unlocking new possibilities for disease modeling\, drug discovery\, and cell therapy. BoutIQ Solutions is redefining media innovation for the future of regenerative medicine. \nTeam members: Julie Audet\, Craig Simmons\, Neal Callaghan\, Alice Feng\, Doris Adao\, Heta Lad \n\nChase Biotherapeutics\nBreaking barriers to advance tissue regeneration \nChase Biotherapeutics is pioneering a breakthrough therapy to improve the quality of life of stroke and spinal cord injury survivors. With no viable treatments for over 12 million patients worldwide\, our disruptive technology enables the precise and localized promotion of neurorepair. Proven safe and effective in preclinical studies\, we are now advancing toward clinical trials with expert collaborators\, addressing a critical unmet need with a truly disease-modifying solution. \nTeam Members: Molly Shoichet\, Nitzan Letko Khait\, Quinton Sirianni\, Elisa Guo\, David Li \n\nLinker\nThe missing lnc for regenerative medicine \nLinker mined the dark transcriptome of humans to re-engineer long non-coding RNA (lncRNA) molecules into therapeutic products that treat inflammation associated with atherothrombotic cardiovascular disease\, which addresses a significant and underserved global clinical need. \nTeam members: Omar F. Khan\, Janice Pang \n\nPI16 Biosciences\nPioneering regenerative medicine-based solutions for skin vitality. \nOur vision at PI16 Biosciences is to harness the potential of regenerative fibroblasts to treat skin conditions with clinical grade skincare formulations that prevent infection and promote vitality. \nTeam members: Matthew Buechler\, Anthony Altieri\, Maye Cheng\, Erika McCartney\, Jia Du\, Yein Chung \n\nZearUp\nPutting an End to Low Blood Sugar: No Pill\, no Pain\, just a Patch! \nZearUp is a team of UofT pharmaceutical scientists dedicated to translating their diabetes research technology into a first-in-class clinical solution for hypoglycemia prevention in insulin-dependent individuals. Their patented ‘smart’ microgel formulation embedded within a biocompatible\, user-friendly microneedle patch is designed to raise blood sugar only when needed. Eliminating dependence on glucose monitoring and hypoglycemia rescue solutions (e.g.\, glucose pills/juice\, glucagon injections/inhalers)\, ZearUp’s patch offers unparalleled peace-of-mind\, transformative to diabetes management. \nTeam members: Xiao Yu (Shirley) Wu\, Jackie Fule Liu\, Brian Lu\, Jamie Lugtu-Pe URL:https://mbd.ccrm.ca/event/pitch-comp-biotech-venture/ LOCATION:Myhal Centre for Engineering Innovation and Entrepreneurship\, Room 150\, 55 St George St\, Toronto\, Ontario\, M5S 0C9\, Canada CATEGORIES:Co-hosted Events END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20250422T120000 DTEND;TZID=America/Toronto:20250422T130000 DTSTAMP:20250401T182418Z CREATED:20240416T192233Z LAST-MODIFIED:20250401T182418Z UID:33777-1745323200-1745326800@mbd.ccrm.ca SUMMARY:Global Speaker Series: Karen Hirschi\, PhD - University of Virginia School of Medicine DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design is pleased to welcome Karen Hirschi\, PhD\, for a talk titled\, ‘Regulation of Endothelial Specialization in Development and Disease.’ \nKaren Hirschi is an Alumni Professor of Cell Biology\, University of Virginia School of Medicine\, Director\, UVA Developmental Genomics Center\, Associate Director for Scientific Programs\, UVA Medical Scientist Training Program\, and Adjunct Professor\, Yale University School of Medicine & Baylor College of Medicine. \nThis event will be held at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room. \nRegister here\n\n \nAbout Karen Hirschi\nKaren K. Hirschi received an Honors BS at Pennsylvania State University and PhD in Nutritional Biochemistry at the University of Arizona. She did her postdoctoral training in vascular cell and developmental biology at Harvard Medical School\, and began her first tenure-track faculty position at Baylor College of Medicine\, where she became a tenured Professor and was the founding Deputy Director of the Stem Cell and Regenerative Medicine Center. Dr. Hirschi moved to Yale University School of Medicine\, where she served as a Professor in the Departments of Medicine and Genetics and as a Co-Director of the Cardiovascular Research Center. Her lab is currently at University of Virginia School of Medicine\, where she serves as the Alumni Professor of Cell Biology and founding Director of the Developmental Genomics Center that focuses on identifying genetic mutations that cause developmental disorders. The Hirschi lab is primarily interested in vascular development and focuses on elucidating regulators of endothelial cell differentiation and specialization\, as well as modulators of endothelial cell proliferation during vessel formation. They use the mouse model system to study the regulation of these processes in vivo. Insights gained are applied to the modulation of the commitment of pluripotent human stem cells toward vascular cell fates\, and to the genesis and optimization of clinically relevant strategies to promote endogenous vascular regeneration and repair in disease conditions. URL:https://mbd.ccrm.ca/event/global-speaker-series-karen-hirschi/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Global Speaker Series ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20250312T120000 DTEND;TZID=America/Toronto:20250312T130000 DTSTAMP:20250220T145524Z CREATED:20250213T143125Z LAST-MODIFIED:20250220T145524Z UID:35156-1741780800-1741784400@mbd.ccrm.ca SUMMARY:Careers Beyond Academia DESCRIPTION:What are you doing after you graduate? This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nThis session will focus on medical affairs and feature the following speakers: \nMichelle Francisco\, MSc \nMedical Excellence and Operations Manager\, Astellas Pharma \nBryan Tennant CD\, PhD \nScientific Director\, GSK Canada \nREGISTER HERE URL:https://mbd.ccrm.ca/event/careers-beyond-academia-5/ LOCATION:Online CATEGORIES:Career Speaker Series,Co-hosted Events END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20250304T120000 DTEND;TZID=America/Toronto:20250304T130000 DTSTAMP:20250225T161919Z CREATED:20241024T142418Z LAST-MODIFIED:20250225T161919Z UID:34708-1741089600-1741093200@mbd.ccrm.ca SUMMARY:Global Speaker Series: Lorenz Studer\, MD - Memorial Sloan-Kettering Cancer Center DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design is pleased to welcome\, Lorenz Studer\, MD\, Director\, Center for Stem Cell Biology\, Memorial Sloan-Kettering Cancer Center. \nTalk title: Applications of human PSCs in modeling and treating neural disease \nThis event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room. \nREGISTER HERE\nAbout Lorenz Studer \n\nLorenz Studer investigates human stem cells as tools to understand normal and pathological development in the nervous system and to develop cell-based therapies.  \nHis interest in medicine began when he was about 18. He had been in the hospital himself for an unusual type of bone infection and had also lost several close relatives to cancer. He decided to go to medical school\, spending my first two years at the University of Fribourg and the latter four at the University of Bern. There\, he met Christian Spenger\, a neurosurgery fellow who thought we might be able to treat Parkinson’s disease in animals by implanting fetal tissue to yield healthy new brain cells. This idea of replacing damaged brain cells seemed revolutionary to him. \nAfter he earned my MD degree in 1991\, Christian and he set up a laboratory at the University of Bern. We were given a room that had been used to store brooms. But it was a good size\, and they managed to get funding for the resources they needed. \nThey began tissue culture studies and developed ways to ensure quality control of the animal fetal tissue cells. He developed an assay to measure the cells’ ability to produce dopamine — the chemical whose deficiency causes the symptoms of Parkinson’s. They also studied the effects of proteins necessary for the growth of specific brain cells. Their early work culminated in 1995\, when they implanted human fetal nerve cells into a Parkinson’s patient. \nTalk abstract \nHuman pluripotent stem cells (hPSCs) present a powerful tool for studying human disease and for developing novel cell-based therapies in regenerative medicine. Our group has developed strategies to coax human PSCs into many specific neuron subtypes on demand and at scale. For some lineages\, such as midbrain dopamine neurons\, those efforts have recently translated into a first-in-human clinical trial using clinical grade\, “off-the-shelf” dopamine neurons for treating patients with advanced Parkinson’s disease (PD). I will provide an update on the results from this trial and discuss some of the next steps and potential next generation products in PD cell therapy development. \nI will further discuss recent progress in the lab on chemical and genetic strategies to drive neuronal maturation and aging in human PSC-derived neural cells type that enable improved modeling neural disorders including neurodegenerative disease. Similarly\, new protocols enable the derivation of fast spiking PV+ cortical interneurons\, a neuronal cell type that has been very difficult to generate in past studies\, as PV marker expression and maturation occurs largely during postnatal development\, while hPSC-derived neurons typically capture fetal stages of neural development. Using hPSC-derived PV neurons we applied this protocol to study a set of structural variants highly associated with increased risk for schizophrenia development. This study enabled us to investigate novel interneuron-mediated defects that may be linked to aspects of neuropsychiatric disease. \n  URL:https://mbd.ccrm.ca/event/global-speaker-series-lorenz-studer/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Global Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20250225T120000 DTEND;TZID=America/Toronto:20250225T130000 DTSTAMP:20250211T192412Z CREATED:20241001T173114Z LAST-MODIFIED:20250211T192412Z UID:34554-1740484800-1740488400@mbd.ccrm.ca SUMMARY:Global Speaker Series: Glen Tibbits\, PhD - BC Children's Hospital Research Institute DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design is pleased to welcome\, Glen Tibbits\, PhD\, Distinguished Professor at Simon Fraser University and Co-Director of the Cellular and Regenerative Medicine Centre at the BC Children’s Hospital Research Institute. \nTalk title: Investigating inherited arrhythmias\, and cardiomyopathies using hiPSC-derived cardiomyocytes \nThis event will be held virtually only via Zoom. \nREGISTER HERE\nAbout Glen Tibbits \n\nAfter completing his Bachelor’s degree at McGill University\, Glen subsequently pursued graduate studies at the University of California\, Los Angeles. During his graduate studies at UCLA\, Glen developed a profound curiosity about the electrical and contractile properties of the heart while completing his MSc and PhD at the Brain Research Institute. With an American Heart Association Post-Doctoral Fellowship (PDF)\, he studied cardiac pharmacology in Niigata\, Japan in year one and cardiac biophysics at the UCLA School of Medicine in year two. He subsequently was appointed an Assistant Research Professor of Pediatric Cardiology at UCLA and then moved to Seattle\, WA to become an Assistant Professor at the University of Washington. When a faculty position opened at Simon Fraser University\, he chose to return to Canada after an absence of 15 years. At SFU he was appointed a Tier I Canada Research Chair in Molecular Cardiac Physiology from 2004-2018. The latter allowed him to start building a research program incorporating the use of human induced pluripotent stem cells differentiated into cardiomyocytes (hiPSC-CMs) to understand better inherited cardiac arrhythmias and cardiomyopathies\, more than a decade ago. In June 2024\, he was awarded a Distinguished Professorship at SFU. He is currently the Co-director of the Cellular and Regenerative Medicine Centre (CRMC) at the BC Children’s Hospital Research Institute which is a state-of-the-art facility for generating and phenotyping hiPSC-derived cardiomyocytes and pancreatic β cells.    \nTalk abstract \nAs Co-Director of the Cellular and Regenerative Medicine Centre (CRMC) at the BC Children’s Hospital Research Institute (BCCHR)\, we have been very fortunate to have the resources to build a state-of-the-art facility dedicated to the use of human induced pluripotent stem cell-derived cardiomyocytes (hiPSCCMs) to study cardiac diseases. While it is well established that a hiPSC-CM model offers distinct advantages in modeling cardiac disease and developing new therapies\, there can be limitations. The first part of this talk will address how the CRMC uses technology to overcome some of these disadvantages. The talk will then focus on using hiPSC-CM models to investigate inherited cardiac arrhythmias that can lead to sudden cardiac arrest (SCA). Genetic variants in cardiac ion channels can cause channel dysfunction or channelopathies\, and hiPSC-CM models have been insightful in investigating the mechanisms of these diseases. However\, the leading known cause of sudden cardiac arrest in youth and elite athletes is hypertrophic cardiomyopathy (HCM) which is generally caused by genetic variants of sarcomeric proteins such as the myosin heavy chain and the troponin complex. Exploring the mechanisms of these diseases and discovering improved therapeutics using hiPSC-CMs will be an important focus of the talk. URL:https://mbd.ccrm.ca/event/global-speaker-series-glen-tibbits/ CATEGORIES:Global Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20250212T120000 DTEND;TZID=America/Toronto:20250212T130000 DTSTAMP:20250122T190458Z CREATED:20250122T184931Z LAST-MODIFIED:20250122T190458Z UID:35114-1739361600-1739365200@mbd.ccrm.ca SUMMARY:Careers Beyond Academia DESCRIPTION:What are you doing after you graduate? This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nThis session will focus on regulatory affairs and feature the following speakers: \nZoe Anderson-Jenkins\nAssociate Director – Regulatory CMC\nBlueRock Therapeutics \nTracy Porter\nAssociate Director\, Regulatory Strategy\,\nVertex Pharmaceuticals \nLearn more and register URL:https://mbd.ccrm.ca/event/careers-beyond-academia-4/ LOCATION:Online CATEGORIES:Career Speaker Series,Co-hosted Events END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20250121T120000 DTEND;TZID=America/Toronto:20250121T130000 DTSTAMP:20241121T171053Z CREATED:20241001T172632Z LAST-MODIFIED:20241121T171053Z UID:34550-1737460800-1737464400@mbd.ccrm.ca SUMMARY:Global Speaker Series: Juan Melero-Martin\, PhD - Boston Children's Hospital\, Harvard Medical School DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, is pleased to welcome\, Juan Melero-Martin\, PhD. Dr. Melero-Martin is an Associate Professor of Surgery at Harvard Medical School\, a principal faculty at the Harvard Stem Cell Institute\, and the inaugural incumbent of an endowed Chair in Cardiac Surgery at Boston Children’s Hospital.  \nTalk title: Advancing Vascularization Strategies in Regenerative Medicine \nThis event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room. \nREGISTER HERE\nAbout Juan Melero-Martin \n\nDr. Melero-Martin graduated in Chemical Engineering from the University of Seville\, Spain\, in 1998. After working for three years in Industry\, he earned a Ph.D. in Biochemical Engineering from the University of Birmingham\, UK\, in 2005. He then trained as a post-doctoral fellow in the Vascular Biology Program at Boston Children’s Hospital. In 2008\, he joined the Department of Cardiac Surgery at Boston Children’s Hospital to run a biomedical research laboratory. Currently\, he is an Associate Professor of Surgery at Harvard Medical School\, a principal faculty at the Harvard Stem Cell Institute\, and the inaugural incumbent of an endowed Chair in Cardiac Surgery at Boston Children’s Hospital.  \nDr. Melero-Martin’s research interest is primarily centered on bioengineering blood vessels. He investigates how vascular networks are formed from stem cell differentiation and has developed novel bioengineering applications with clinical translational potential. Dr. Melero-Martin strives to investigate questions that can have a long-lasting impact on regenerative medicine. His research goals are divided into four general categories:  \n\nTherapeutic revascularization of ischemic tissues (i.e.\, vascular cell therapy). \nEngineering organ-specific vascular niches for tissue regeneration. \nGenetically engineering vascular networks for drug delivery.  \nVascularization of organoid systems.  \n\nDr. Melero-Martin’s laboratory is a reference in human progenitor and pluripotent stem cell-derived vascular cells\, areas in which he has contributed multiple original papers. His group has developed novel approaches to bioengineer vascular networks and has shown that bioengineered vascular networks can be used to harness the regenerative potential of other stem cells. In addition\, his group developed a model that uses genetically engineered blood vessels to achieve the controlled release of therapeutic proteins in vivo.  \nDr. Melero-Martin routinely collaborates and provides expertise to other laboratories in the US and abroad. People from other groups continue to come to his laboratory to learn about stem cell-derived vascular cells and models for building blood vessels. Dr. Melero-Martin has a track record of successfully obtaining funds from multiple sources\, including the NIH\, the private sector\, foundations\, and intramural support. The NIH has continuously funded his research since 2009.   URL:https://mbd.ccrm.ca/event/global-speaker-series-juan/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Global Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20241209T081500 DTEND;TZID=America/Toronto:20241209T180000 DTSTAMP:20240730T175236Z CREATED:20240509T165908Z LAST-MODIFIED:20240730T175236Z UID:33825-1733732100-1733767200@mbd.ccrm.ca SUMMARY:Medicine by Design's 9th Annual Symposium DESCRIPTION:Medicine by Design’s 9th Annual Symposium will bring together principal investigators and trainees from across the University of Toronto and its affiliated hospitals along with representatives from our ecosystem partners across industry\, the investment community\, government and the not-forprofit sector\, and international collaborators. \nInvited speakers and Medicine by Design principal  investigators and trainees will share the impacts of their research across the innovation continuum. We will also hold a poster session featuring the research of select trainees working on Medicine by Designfunded projects. \nMore details will be available soon. URL:https://mbd.ccrm.ca/event/medicine-by-designs-9th-annual-symposium/ LOCATION:MaRS Auditorium\, 101 College Street\, Toronto\, Ontario\, M5G 1L7\, Canada CATEGORIES:Symposium END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20241121T153000 DTEND;TZID=America/Toronto:20241121T170000 DTSTAMP:20241121T144033Z CREATED:20241022T165602Z LAST-MODIFIED:20241121T144033Z UID:34674-1732203000-1732208400@mbd.ccrm.ca SUMMARY:Building a Biotech Venture Program Information Session and Networking DESCRIPTION:Join us on November 21 for an information session to learn about the Building a Biotech Venture program.\nREGISTER HERE\nProgram Information Session and Networking\nNovember 21 from 3:30pm-5:00pm \nDonnelly Centre\, Red Room (160 College Street\nToronto)\nAt the program information session: \n– Learn how to successfully apply to the program \n– Get an overview of the business canvas\, a key component of the application \n– Hear from previous years’ pitch finalists \n– Network with other interested trainees and/or form a team \n \nTake your first steps toward entrepreneurship with the Building a Biotech Venture program\, where regenerative medicine or precision medicine-focused trainee teams learn from industry experts to develop their venture concepts\, create a pitch deck and business canvas\, and set milestones for building their company. \nThe Building a Biotech Venture program will include a series of workshops where teams will:  \n\nLearn how to think about their research in terms of a product or business\nBuild a business canvas and develop their product or venture concept\nReceive guidance from industry experts on intellectual property\, clinical translation\, and early-stage stage investment\, and preclinical experimental de-risking.\nCreate a pitch deck and receive coaching on telling their venture story\nReceive mentoring throughout the process.\n\nThe program will culminate in a pitch competition for selected teams where the top teams will receive up to $25\,000 in research funding to advance their venture. \n\n\nPlease email any questions about this program to prime.initiative@utoronto.ca. URL:https://mbd.ccrm.ca/event/building-a-biotech-venture-program-information-session-and-networking-2/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Partner Events,Workshops END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20241120T120000 DTEND;TZID=America/Toronto:20241120T130000 DTSTAMP:20241029T184932Z CREATED:20241029T184732Z LAST-MODIFIED:20241029T184932Z UID:34735-1732104000-1732107600@mbd.ccrm.ca SUMMARY:Careers Beyond Academia - Danielle Spice and Kevin Robb DESCRIPTION:Speakers:\nDanielle Spice\, PhD\nLead Scientist I\, Stealth Mode Biotech \nKevin Robb\, PhD\nScientist\, STEMCELL Technologies \n\nCareers Beyond Academia\n“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. For previous recordings of Careers Beyond Academia see here. \nWho Should Attend?\nAttendees should be research trainees‡ who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \n‡ A research trainee is a graduate student\, post-doc\, research associate and/or technician currently working a Canadian lab. \nLearning Objectives:\n\nHelp trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be\nExpose candidates to careers that they might not have previously considered as typical careers in the life sciences\n\n\n\n\n\n\nDate\nConfirmed Speakers\nLink to Register\n\n\n\n\nNovember 20\, 2024\nDanielle Spice\, PhD\nLead Scientist I\, Stealth Mode Biotech  \nKevin Robb\, PhD\nScientist\, STEMCELL Technologies\nSign up here! URL:https://mbd.ccrm.ca/event/careers-beyond-academia-danielle-spice-and-kevin-robb/ CATEGORIES:Career Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20241107T110000 DTEND;TZID=America/Toronto:20241107T120000 DTSTAMP:20241015T193636Z CREATED:20241001T172231Z LAST-MODIFIED:20241015T193636Z UID:34548-1730977200-1730980800@mbd.ccrm.ca SUMMARY:Global Speaker Series: Emily R. Miraldi\, PhD - Cincinnati Children's Hospital Medical Center DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, is pleased to welcome\, Emily R. Miraldi\, PhD. Dr. Miraldi is an Associate Professor of Immunobiology and Biomedical Informatics at the Cincinnati Children’s Hospital Medical Center. \nTalk title: “Inference of gene regulatory mechanisms from scRNA-seq and scATAC-seq” \nThis event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room as well as virtually. \nThis event is co-sponsored by the Donnelly Centre for Cellular & Biomolecular Research. \n\n  \nREGISTER HERE\nAbout Emily R. Miraldi \n\nDr. Miraldi is an Associate Professor of Immunobiology and Biomedical Informatics at the Cincinnati Children’s Hospital Medical Center. \nHer lab’s research goal is immuno-engineering: to alter the behavior of specific immune cell populations in disease contexts (autoimmune disease\, organ transplant\, and cancer) without compromising the body’s homeostatic immune function (e.g. defense against pathogens). Thus\, it is critical to develop a nuanced understanding of how different immune cells sense and respond to environmental cues across the body\, in both physiological and disease settings. To this end\, her lab’s major focus is reverse-engineering the underlying logic of immune cells (molecular networks that drive cellular responses) from high-dimensional molecular measurements of immune cells in action (sensing and responding to perturbations\, disease conditions\, etc.). \nThe lab’s focus is transcriptional regulatory network inference\, modeling gene expression as a function of transcription factor activities\, from gene expression and measurements of chromatin state. Chromatin accessibility measurements by ATAC-seq\, together with transcription-factor DNA-binding preferences (motifs)\, can be used to broadly profile potential transcription factor binding events in relatively small populations of cells. Thus\, we have used ATAC-seq with RNA-seq to enable de novo inference of transcriptional regulatory networks in physiological settings where sample material is limiting (e.g.\, intestinal immune cells in response to microbial/genetic perturbations). To date\, most of these efforts have been in mouse models\, as it is generally not possible to obtain sufficient sample material for similar experimental designs in human. To build human immune cell models\, we are developing multi-task learning approaches to leverage evolutionarily conserved relationships and borrow statistical power from mouse datasets for inference in human. We are also developing methods to enable transcriptional regulatory network inference in very rare cell populations\, as measured from single-cell RNA-seq experiments. URL:https://mbd.ccrm.ca/event/global-speaker-series-emily-miraldi/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Global Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20241016T120000 DTEND;TZID=America/Toronto:20241016T130000 DTSTAMP:20240905T143550Z CREATED:20240905T143550Z LAST-MODIFIED:20240905T143550Z UID:34424-1729080000-1729083600@mbd.ccrm.ca SUMMARY:Careers Beyond Academia - Kristel Bermejo and Jenny Crick DESCRIPTION:Speakers:\nKristel Bermejo\nFreelance Medical Writer at MKB MedSolutions \nJenny Crick\nEditorial Outreach Specialist at Canadian Science Publishing \n\nCareers Beyond Academia\n“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. For previous recordings of Careers Beyond Academia see here. \nWho Should Attend?\nAttendees should be research trainees‡ who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \n‡ A research trainee is a graduate student\, post-doc\, research associate and/or technician currently working a Canadian lab. \nLearning Objectives:\n\nHelp trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be\nExpose candidates to careers that they might not have previously considered as typical careers in the life sciences\n\n\n\n\n\n\nDate\nConfirmed Speakers\nLink to Register\n\n\n\n\nOctober 16\, 2024\nKristel Bermejo\nFreelance Medical Writer at MKB MedSolutions \nJenny Crick\nEditorial Outreach Specialist at Canadian Science Publishing\nSign up here! URL:https://mbd.ccrm.ca/event/careers-beyond-academia-kristel-bermejo-and-jenny-crick/ CATEGORIES:Career Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20241007T120000 DTEND;TZID=America/Toronto:20241007T130000 DTSTAMP:20240808T132739Z CREATED:20240416T192016Z LAST-MODIFIED:20240808T132739Z UID:33775-1728302400-1728306000@mbd.ccrm.ca SUMMARY:Global Speaker Series: Robert Signer\, PhD - University of California\, San Diego DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Robert Signer\, PhD. Dr. Signer is Deputy Director of the Stem Cell Discovery Center and an Associate Professor of Medicine in the Division of Regenerative Medicine at the University of California San Diego. \nHosted by Medicine by Design\, in partnership with the McEwen Stem Cell Institute.  \nTalk title: “Stem Cell Fitness & Longevity: The Role of Proteostasis”  \nThis event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room. \nREGISTER HERE\nAbout Robert Signer \n\nDr. Robert Signer is a stem cell biologist whose trailblazing work on protein synthesis and homeostasis in blood-forming stem cells opened the door to unchartered areas of cellular investigation. Dr. Signer is currently the Deputy Director of the Sanford Stem Cell Discovery Center and an Associate Professor of Medicine in the Division of Regenerative Medicine at UC San Diego.  \nPreviously\, Dr. Signer trained as a Postdoctoral Fellow at the UT Southwestern Medical Center. He earned a Ph.D. in Cellular and Molecular Pathology at UCLA\, and a Bachelor’s in Engineering Science from the University of Toronto. His discoveries have been recognized by numerous awards from the Leukemia and Lymphoma Society\, the V Foundation for Cancer Research\, and the California Institute for Regenerative Medicine\, among others. He was named a Distinguished International Young Investigator in Stem Cell Research and is the 2024 recipient of the prestigious Janet Rowley Award from the International Society of Experimental Hematology.  \nTalk abstract \nHematopoietic stem cells (HSCs) persist throughout life to regenerate blood cells lost to physiological turnover\, injury and disease. But how stem cells preserve their immense regenerative potential while simultaneously sustaining their remarkable longevity remains a mystery. The regulation of protein homeostasis (proteostasis) has emerged as being fundamentally and preferentially important for HSCs. Proteostasis is maintained by an integrated network of physiological mechanisms and stress response pathways that coordinate protein synthesis\, folding\, trafficking and degradation to regulate the content and quality of the proteome. Many of these highly-conserved pathways have long been thought of as housekeeping functions\, performed similarly by most cells. However\, we found that HSCs exhibit unique cell-type-specific configuration of the proteostasis network that is critical for preserving their fitness\, health and longevity. Young adult HSCs exhibit unusually low protein synthesis rates to restrict the biogenesis of misfolded proteins in vivo and utilize non-canonical protein trafficking and degradation pathways to limit the accumulation of protein aggregation to preserve their long-term self-renewal potential. Challenges to proteostasis during aging cause HSCs to remodel their proteostasis network to sustain their fitness and regenerative potential. However\, adapting to these selective pressures comes at the cost of increasing the risk of premalignant and malignant disease. Overall\, unique and dynamic regulation of proteostasis is key for balancing stem cell regeneration and longevity. URL:https://mbd.ccrm.ca/event/global-speaker-series-robert-signer-phd-uc-san-diego/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Global Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20240918T120000 DTEND;TZID=America/Toronto:20240918T130000 DTSTAMP:20240917T124114Z CREATED:20240827T150326Z LAST-MODIFIED:20240917T124114Z UID:34326-1726660800-1726664400@mbd.ccrm.ca SUMMARY:Careers Beyond Academia - Francis Jeanson and Brendan Behan DESCRIPTION:Speakers:\nFrancis Jeanson\, PhD – Head of Centre for Analytics at Ontario Brain Institute \nBrendan Behan\, PhD – Director\, Data Strategy and Partnerships at Vector Institute \n\nCareers Beyond Academia\n“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. For previous recordings of Careers Beyond Academia see here. \nWho Should Attend?\nAttendees should be research trainees‡ who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \n‡ A research trainee is a graduate student\, post-doc\, research associate and/or technician currently working a Canadian lab. \nLearning Objectives:\n\nHelp trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be\nExpose candidates to careers that they might not have previously considered as typical careers in the life sciences\n\n\n\n\n\n\nDate\nConfirmed Speakers\nLink to Register\n\n\n\n\nSeptember 18\, 2024\nFrancis Jeanson\, PhD – Head of Centre for Analytics at Ontario Brain Institute \nBrendan Behan\, PhD – Director\, Data Strategy and Partnerships at Vector Institute \n \nSign up here! URL:https://mbd.ccrm.ca/event/careers-beyond-academia-francis-jeason-and-brendan-behan/ CATEGORIES:Career Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;VALUE=DATE:20240610 DTEND;VALUE=DATE:20240620 DTSTAMP:20240509T145323Z CREATED:20240509T145323Z LAST-MODIFIED:20240509T145323Z UID:33823-1717977600-1718841599@mbd.ccrm.ca SUMMARY:Summer by Design 2024 DESCRIPTION:How do you move innovative discoveries out of the lab efficiently and effectively so patients benefit sooner? What are the steps involved in translating and commercializing regenerative medicine discoveries? What career opportunities exist beyond academia? \nSummer by Design is an intensive program for PhD students and post-doctoral fellows from Canadian and international universities that will run from June 10 to 19\, 2024\, at the University of Toronto. \nThis eight-day program will feature expert-led\, interactive sessions including lectures\, group work and case studies. \nParticipants will: \n\nMake connections with international peers\nExplore Toronto’s dynamic life sciences hub by meeting with clinical and industry leaders in regenerative medicine\nLearn from experts across the technology translation continuum and be introduced to important topics in the commercialization of regenerative medicine\n\nLearn more about Summer by Design. \n  URL:https://mbd.ccrm.ca/event/summer-by-design-2024/ CATEGORIES:Partner Events ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20240514T120000 DTEND;TZID=America/Toronto:20240514T130000 DTSTAMP:20240402T164948Z CREATED:20240105T165551Z LAST-MODIFIED:20240402T164948Z UID:33214-1715688000-1715691600@mbd.ccrm.ca SUMMARY:Global Speaker Series: Mingxia Gu\, MD\, PhD - Cincinnati Children's Hospital Medical Center DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nJoin speaker\, Mingxia Gu\, Assistant Professor of Pediatrics at Cincinnati Children’s Hospital Medical Center. \nHosted by Medicine by Design\, in partnership with the McEwen Stem Cell Institute.  \nTalk title: Unveiling the Mysteries of Vascular Development and Regeneration with Advanced Human Organoid Models \nREGISTER HERE\nAbout Mingxia Gu \n\n  \n  \n  \n  \nDr. Mingxia Gu is an Assistant Professor of Pediatrics at Cincinnati Children’s Hospital Medical Center. She received her medical training from Peking University in Beijing\, China\, and pursued a joint-training Ph.D. program at Peking University and Stanford University in Dr. Joseph Wu’s laboratory. Following her time as an AHA postdoctoral fellow in Dr. Marlene Rabinovitch’s lab at Stanford\, she joined Cincinnati Children’s Hospital Medical Center in early 2020\, holding joint appointments in the Center for Stem Cell & Organoid Medicine (CuSTOM) and Divisions of Pulmonary Biology\, Molecular Cardiovascular Biology\, and Developmental Biology. Dr. Gu has published at top-tier journals\, such as Cell Stem Cell\, Science Translational Medicine\, and Circulation Research\, and her lab is well-funded by NIH\, the Single Ventricle Research Foundation\, and the American Heart Association. The Gu lab focuses on dissecting signaling mechanisms guiding tissue-specific endothelial cell fate commitment and developing innovative therapeutic strategies for regenerating vascular beds in congenital heart and lung defects. \nTalk abstract \nTo investigate the co-development of vasculature\, mesenchyme\, and epithelium crucial for organogenesis and the acquisition of organ-specific characteristics\, we constructed a human pluripotent stem cell-derived organoid system comprising lung or intestinal epithelium surrounded by organotypic mesenchyme and vasculature. We demonstrated the pivotal role of co-differentiating mesoderm and endoderm via precise BMP regulation in generating multilineage organoids and gut tube patterning. Single-cell RNA-seq analysis revealed organ specificity in endothelium and mesenchyme\, and uncovered key ligands driving endothelial specification in the lung (e.g.\, WNT2B and Semaphorins) or intestine (e.g.\, GDF15). Upon transplantation under the kidney capsule in mice\, these organoids further matured and developed perfusable human-specific sub-epithelial capillaries. Additionally\, our model recapitulated the abnormal endothelial-epithelial crosstalk in patients with FOXF1 deletion or mutations. Multilineage organoids provide a unique platform to study developmental cues guiding endothelial and mesenchymal cell fate determination\, and investigate intricate cell-cell communications in human organogenesis and disease. \nThis event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room. URL:https://mbd.ccrm.ca/event/global-speaker-series-mingxia-gu-md-phd-cincinnati-childrens-hospital-medical-center/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Global Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20240429T120000 DTEND;TZID=America/Toronto:20240429T130000 DTSTAMP:20240402T164803Z CREATED:20240116T203138Z LAST-MODIFIED:20240402T164803Z UID:33380-1714392000-1714395600@mbd.ccrm.ca SUMMARY:Global Speaker Series: Erika Moore\, PhD - University of Maryland\, College Park DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nJoin speaker\, Erika Moore\, Assistant Professor\, Fischell Department of Bioengineering\, A. James Clark School of Engineering\, University of Maryland\, College Park. \nHosted by Medicine by Design\, in partnership with the McEwen Stem Cell Institute.  \nTalk title: Bridging the Gap: In vitro Preclinical Models to Investigate the Role of Macrophages in Tissue Regeneration \nRegister here\nAbout Erika Moore \n\nDr. Erika Moore is an Assistant Professor in the Fischell Department of Bioengineering at the University of Maryland\, College Park. She defended her Ph.D. in Biomedical Engineering from Duke University in May 2018. She earned her bachelor’s degree in Biomedical Engineering from the Johns Hopkins University in 2013. Her work focuses on understanding the role of macrophage immune cells in tissue repair and regeneration through the design of in vitro preclinical models\, spanning age-associated macrophage function\, macrophage-vasculitis mediation in lupus\, and macrophage integrin ligand interactions within the extracellular matrix. The mission of the Moore lab is to engineer biomaterial models that leverage the regenerative potential of the immune system across health inequities. To execute on this mission\, Dr. Moore develops compassionate innovators equipped to transform biomedical research. Recently acknowledged as Forbes 30 Under 30 in the Healthcare category\, Dr. Moore’s notable awards include the N.I.H. R35 Maximizing Investigators Research Award\, the Lupus Research Alliance Career Development Award\, the BMES Rita Schaffer Award\, the 3M Non-Tenured Faculty Award and NSF CAREER Award. \nThis event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room. URL:https://mbd.ccrm.ca/event/global-speaker-series-erika-moore-phd-university-of-maryland-college-park/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Global Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20240327T150000 DTEND;TZID=America/Toronto:20240327T170000 DTSTAMP:20240322T152245Z CREATED:20240229T161928Z LAST-MODIFIED:20240322T152245Z UID:33476-1711551600-1711558800@mbd.ccrm.ca SUMMARY:Pitch Competition: Building a Biotech Venture program DESCRIPTION:Join us in-person for the Building a Biotech Venture Pitch Competition to learn how the next generation of regenerative and precision medicine researchers are preparing to translate their discoveries toward impact. \nRegister here\nWatch as six trainee-led teams from the University of Toronto and its affiliated hospitals pitch their ventures to an expert panel of judges. The winning team will receive $25\,000\, and the second-place team will receive $10\,000 in research funding to advance their product concept. \nThe competition is the culmination of Medicine by Design’s Building a Biotech Venture program\, offered in partnership with the Precision Medicine Initiative (PRiME)\, Health Innovation Hub (H2i) and Talk Boutique. Over the past several months\, teams have worked with mentors to advance early-stage company concepts based on their research and have participated in a series of workshops to develop their business cases. \nCome cheer on these up-and-coming entrepreneurs as they showcase their innovative technologies. \nLocation: \nWilliam Doo Auditorium \n45 Willcocks St\, Toronto\, ON M5S 2H3 \n\n\nMeet the judges\nElla Korets-SmithMathew Platt Robin QuirkSuman Rao Ella Korets-Smith Chief Strategy Officer and Co-Founder\, Virica Biotech \nElla is an entrepreneur and business development executive for over 15 years. She has a strong track record of deals\, working with companies such as IMV Inc.\, Nordion Inc\, and Antibe Therapeutics Inc\, driving fundraising and liquidity events. In roles of increasing responsibility\, she has lead successful marketing and business development programs resulting in annual sales of over $50M. Ms. Korets-Smith has an M.Sc. in Medical Genetics from the University of Toronto and an M.B.A. from Dalhousie University. \nMathew Platt Global Head of Venture Recruitment\, Creative Destruction Lab\nMathew is an academic by training who received his PhD in Human Health from the University of Guelph in 2019. He launched his post-academic career in deep tech startups as a Health Venture Manager at the Creative Destruction Lab (CDL) in February of 2020. In his time at CDL-Toronto\, Mathew reviewed over 500 health startup applications to the program\, worked directly with 35 health ventures spanning devices to diagnostics to drug discovery/development\, led their Health-Therapeutics stream in the fall of 2021 as a Senior Venture Manager\, and helped launch CDL-Advanced Therapies and CDL-Biomedical Engineering in the spring of 2022 as Toronto’s Associate Director of Health Streams. \nRobin Quirk Vice President Technology Sourcing & Venture Development\, CCRM\nRobin has over 20 years of experience working with regenerative medicine start-up companies. He started his career as an industry-trained pharmacist before moving into tissue engineering research. Robin joined CCRM to support the commercial development of early-stage ideas. He leads the team responsible for identifying and developing promising technologies and nurturing them to the company creation stage by strategically leveraging CCRM’s expertise and infrastructure. \nSuman Rao Senior Associate\, Lumira Ventures \n                                                                                     Suman joined Lumira in 2021 as an Associate and focuses on conducting scientific and technical diligence of investment opportunities.  Prior to joining Lumira Ventures\, Suman worked in healthcare consulting at L.E.K. Consulting in Boston as a Life Sciences Specialist. During her time at L.E.K.\, she provided strategic advice on growth opportunities\, pipeline expansion\, potential M&A partnerships and financial modeling. Before joining L.E.K.\, Suman spent 4 years doing a Postdoctoral Fellowship at Harvard Medical School and Dana Farber Cancer Institute. During this time\, she worked with a multidisciplinary team to develop therapies to treat advanced cancers.   \n\nMeet the teams\n\nCHI Diagnostics\nThe problem is inflammation.\nAt CHI Diagnostics\, we have developed a blood test that can revolutionize post-transplant care by accurately detecting genetic markers associated with inflammation and identifying which patients are at risk of complications. This empowers us to offer personalized healthcare interventions\, minimizing invasive tests for low-risk individuals and ensuring proactive measures for those at higher risk\, ultimately optimizing post-transplant outcomes. \nTeam members: Tafsia Hussain\, Filio Billia\, John Dick\, Sagi Abelson\, Fernando Luis Scolari\, Jessie Medeiros\, Darshan H. Brahmbhatt\, Gary Bader \n\nHelixir\nEnhancing the physicians’ MR eyes.\nHelixir will use stem cell therapies to treat heart attack to demonstrate that regenerative therapies need the complement of our proprietary delivery technology to enable improved accuracy and increased therapeutic retention. This will then open the door for more minimally invasive regenerative therapies that require our pinpoint treatment delivery system. \nTeam members: Daniel Djayakarsana\, Jaykumar Patel\, Moses Cook \n\nNorthMiRs\, Inc.\nDeveloping nanotechnology-enables gene therapies to address the underlying immune dysregulation of sepsis.\nSepsis is the most common cause of death in critically ill patients\, doctors have to rely on supportive care for these patients as there are no specific treatments addressing the underlying immune dysregulation of the condition. NorthMiRs is changing this standard of care by developing a library of microRNA-based therapies that treats both systemic inflammation and organ-specific dysfunctions to ultimately improve patient outcomes\, free up space in the ICU\, and reduce the financial burden on the health system. \nTeam members: Samantha McWhirter\, Logan Zettle\, Chirag Vaswani\, Amin Ektesabi \n\nRe:Pair Genomics\nRepairing the “cures”.\nWe’ve developed AI software to design compact GPS DNAs for gene therapy to make it safe and increase product success in the clinic. What traditionally takes scientists 3-6 months can now be generated within a day. Our innovation holds significant promise for biotech and pharmaceutical firms engaged in gene therapy research and development. \nTeam members: Luca Hategan\, Yosuke Niibori\, Shiron Lee\, Swapna Prakash \n\nTwenty-nine Therapeutics\nHarnessing the power of the copper atom (element 29) to diagnose and treat metastatic disease.\nProject Twenty Nine Therapeutics includes the exploration of a promising radiopharmaceutical candidate\, Copper 67 (Cu-67)\, including its various nanomedicine applications. Cu-67 usage is novel and holds potential in theranostics and diagnostic imaging. The project Twenty Nine Therapeutics team is proposing a theranostic pairing of Copper 64 and Copper 67\, making this the first combination of these two isotopes in a nanoparticle. The isotope also has unexplored promise in the treatment of various cancers\, particularly those that have metastasized to the peritoneal lining. The team is exploring ways to firstly\, manufacture and safely ship Cu-67 and secondly\, examining its various therapeutic applications. \nTeam members: Michael Valic\, Gang Zheng \n\nVrit\nA macroporous collagen particle (MCP) based bioink and handheld bioprinter for treating full thickness skin defects.\nAt Vrit\, we’re pioneering a future where autografts are no longer necessary for surgeries. Our handheld bioprinter\, part of our broader biomaterials initiative\, empowers surgeons to provide advanced care to patients by eliminating the reliance on traditional invasive techniques. \nTeam members: Sushant Singh\, Zhenglin Lu\, Michael Li Diao URL:https://mbd.ccrm.ca/event/pitch-competition-building-a-biotech-venture-program-2024-2/ LOCATION:William Doo Auditorium\, 45 Willcocks St\, Toronto\, Ontario\, M5S 2H3\, Canada CATEGORIES:Co-hosted Events ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20240313T120000 DTEND;TZID=America/Toronto:20240313T130000 DTSTAMP:20231220T162922Z CREATED:20231220T162922Z LAST-MODIFIED:20231220T162922Z UID:33195-1710331200-1710334800@mbd.ccrm.ca SUMMARY:Careers Beyond Academia - Ahmed Tanashi and Elisa Porfilio DESCRIPTION:Speakers:\nAhmed Tanashi – Advisor\, Business Development\, Mitacs \nElisa Porfilio – Engagement Leader\, Shift Health \n\nCareers Beyond Academia\n“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. For previous recordings of Careers Beyond Academia see here. \nWho Should Attend?\nAttendees should be research trainees‡ who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \n‡ A research trainee is a graduate student\, post-doc\, research associate and/or technician currently working a Canadian lab. \nLearning Objectives:\n\nHelp trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be\nExpose candidates to careers that they might not have previously considered as typical careers in the life sciences\n\n\n\n\n\n\nDate\nConfirmed Speakers\nLink to Register\n\n\n\n\nMarch 13\, 2024\nAhmed Tanashi – Advisor\, Business Development\, Mitacs \nElisa Porfilio – Engagement Leader\, Shift Health \n \n\n\n\n\nSign up here! URL:https://mbd.ccrm.ca/event/careers-beyond-academia-ahmed-tanashi-and-elisa-porfilio/ CATEGORIES:Career Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20240312T120000 DTEND;TZID=America/Toronto:20240312T130000 DTSTAMP:20240213T154021Z CREATED:20230921T175724Z LAST-MODIFIED:20240213T154021Z UID:21198-1710244800-1710248400@mbd.ccrm.ca SUMMARY:Global Speaker Series: Shruti Naik\, PhD - New York University Grossman School of Medicine DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nJoin speaker\, Shruti Naik\, Associate Professor in Pathology\, Medicine and Dermatology and Associate Director of the Colton Center for Autoimmunity at NYU Grossman School of Medicine. \nTalk title: Immune-mediated mechanisms of tissue adaptation and maladaptation. \nREGISTER HERE\nAbout Shruti Naik \n\n  \n  \n  \n  \nDr. Shruti Naik\, Ph.D.\, holds the position of Associate Professor in Pathology\, Medicine and Dermatology and also serves as the Associate Director of the Colton Center for Autoimmunity at NYU Grossman School of Medicine. \nDr. Naik is an international leader in immunology and regenerative medicine. Her research examines how Psoriasis and Inflammatory Bowel Disease\, the most common chronic inflammatory diseases that collectively affect ~5% of the Western population\, profoundly impair organ function. By leveraging cutting-edge technologies to study mechanisms of how immune cells comminate with tissues in health and disease\, Naik seeks to develop curative therapies that halt inflammatory damage and rejuvenate organs at the cellular and molecular level. \nDr. Naik earned her B.S. in Cell and Molecular Biology from the University of Maryland College Park and subsequently obtained her Ph.D. through the University of Pennsylvania-NIH graduate partnership program under the mentorship of Drs. Yasmine Belkaid and Julie Segre. She further honed her expertise as s Damon Runyon Postdoctoral Fellow at the Rockefeller University in New York City. \nIn addition to her outstanding research contributions\, Dr. Naik is a strong advocate for increasing diversity in science. She is also committed to mentoring the next generation of scientists and physicians. Her involvement extends to serving on Scientific Advisory Board of the Keystone Symposium and her role as an Executive Producer of the film Six Degrees from Science. Dr. Naik has received numerous accolades for her groundbreaking research and advocacy including the Regeneron Award for Creative Innovation\, the L’Oréal For Women in Science Award\, the Damon Runyon Dale F. Frey Award for Breakthrough Scientist\, the Blavatnik Award for Young Scientists\, the International Takeda International Innovators in Science Award\, Pew-Stewart Scholar\, NIH Directors Innovator Award DP2\, Packard Fellow\, Burrows Welcome PATH award\, and is a NYSCF Robertson Stem Cell Investigator. \nTalk abstract \nThe epithelial tissues that line our body routinely experience inflammation inducing pathogenic and noxious agents. The mechanisms and consequences of how epithelial tissues\, and in particular their long-lived stem cells\, sense\, respond to\, and remember such encounters are only now beginning to unfold. I discuss the crosstalk between immune cells\, epithelial stem cells\, and c microbes and its importance for epithelial health and repair. Understanding these dynamic interactions may provide unique means of boosting epithelial barrier function and healing by modulating immune and microbial signals perceived by stem cells \nHosted by Medicine by Design\, in partnership with the McEwen Stem Cell Institute.  \n This event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room. \n  URL:https://mbd.ccrm.ca/event/global-speaker-series-shruti-naik-phd-new-york-university-school-of-medicine/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Global Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20240207T120000 DTEND;TZID=America/Toronto:20240207T130000 DTSTAMP:20231220T162622Z CREATED:20231220T162622Z LAST-MODIFIED:20231220T162622Z UID:33193-1707307200-1707310800@mbd.ccrm.ca SUMMARY:Careers Beyond Academia - John Preece and Kori St Cyr DESCRIPTION:Speakers:\nJohn Preece – Sector Development Officer\, Life Sciences\, City of Toronto\, Economic Development & Culture \nKori St Cyr – Director\, Policy and Government Relations\, Natural Sciences and Engineering Research Council of Canada (NSERC) \n\nCareers Beyond Academia\n“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. For previous recordings of Careers Beyond Academia see here. \nWho Should Attend?\nAttendees should be research trainees‡ who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \n‡ A research trainee is a graduate student\, post-doc\, research associate and/or technician currently working a Canadian lab. \nLearning Objectives:\n\nHelp trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be\nExpose candidates to careers that they might not have previously considered as typical careers in the life sciences\n\n\n\n\n\n\nDate\nConfirmed Speakers\nLink to Register\n\n\n\n\nFebruary 7\, 2024\nJohn Preece – Sector Development Officer\, Life Sciences\, City of Toronto\, Economic Development & Culture \nKori St Cyr – Director\, Policy and Government Relations\, Natural Sciences and Engineering Research Council of Canada (NSERC)\n\n\n\n\nSign up here! URL:https://mbd.ccrm.ca/event/careers-beyond-academia-john-preece-and-kori-st-cyr/ CATEGORIES:Career Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20240206T120000 DTEND;TZID=America/Toronto:20240206T130000 DTSTAMP:20240131T150148Z CREATED:20230921T175131Z LAST-MODIFIED:20240131T150148Z UID:21193-1707220800-1707224400@mbd.ccrm.ca SUMMARY:Global Speaker Series: Bernard Thébaud\, MD\, PhD – Ottawa Hospital Research Institute DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nJoin speaker Bernard Thébaud\, Senior Scientist\, Regenerative Medicine Program\, Ottawa Hospital Research Institute\, Neonatologist\, Department of Pediatrics\, The Ottawa Hospital and the Children’s Hospital of Eastern Ontario\, Professor\, Department of Pediatrics and Partnership Research Chair\, Regenerative Medicine\, University of Ottawa. \nHosted by Medicine by Design\, in partnership with the McEwen Stem Cell Institute.  \nTalk title: Helping Underdeveloped Lungs with Cells – The HULC trials from Petri dish to Patient  \nREGISTER HERE\nAbout Bernard Thébaud \n\n  \n  \n  \n  \nDr. Bernard Thébaud is a clinician-scientist with a focus on the clinical translation of stem cell-based therapies for lung diseases. He is a senior scientist with the Ottawa Hospital Research Institute and a neonatologist with the Children’s Hospital of Eastern Ontario\, providing care to critically ill newborns. He is also a Professor of Pediatrics at the University of Ottawa.  Dr. Thébaud obtained his MD at the University Louis Pasteur in Strasbourg in France and trained in Pediatrics and Neonatology at the University Paris V\, where he obtained his MSc and PhD before completing a 2-year postdoctoral fellowship at the University of Alberta.  \nDr. Thébaud studies the mechanisms of lung development\, injury and repair to design new treatments for incurable lung diseases. His focus is on answering clinically relevant questions for translation into real-life applications. He is now translating innovative cell and gene therapies from the lab into patients to improve outcomes.  Dr. Thébaud has participated on numerous peer reviews committees and scientific advisory boards at the international\, national and provincial level\, including CIHR and NIH. Dr. Thébaud holds the University of Ottawa Partnership Research Chair in Regenerative Medicine. His research is funded by the Canadian Institutes of Health Research\, the Heart and Stroke Foundation of Canada\, and the Stem Cell Network.  \nTalk abstract \nPreterm birth is a leading cause of infant morbidity and mortality worldwide. Bronchopulmonary dysplasia (BPD)\, the chronic lung disease that follows ventilator and O2 therapy for acute respiratory failure\, is the most common complication of prematurity and accounts for much of the long-term morbidity. BPD lacks effective therapies. Experimental data over the past 15 years have provided some evidence for the potential for cell-based therapies to prevent neonatal lung injury and have led to early phase clinical trials using mesenchymal stromal cells. This presentation will summarize the hazardous path from Petri dish to Patient and acknowledge the current stage of infancy of cell-based therapy. Much more needs to be learned about the biology of these putative repair cells in order to fully harness their therapeutic potential.  \nThis event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room. URL:https://mbd.ccrm.ca/event/global-speaker-series-bernard-thebaud-md-phd-ottawa-hospital-research-institute/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Global Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20240123T120000 DTEND;TZID=America/Toronto:20240123T130000 DTSTAMP:20240111T143704Z CREATED:20230921T175506Z LAST-MODIFIED:20240111T143704Z UID:21196-1706011200-1706014800@mbd.ccrm.ca SUMMARY:Global Speaker Series: Ana Andreazza\, PhD - University of Toronto DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nJoin speaker Ana Andreazza\, Professor in the Departments of Pharmacology & Toxicology and Psychiatry at the University of Toronto\, Tier II Canada Research Chair in Molecular Pharmacology of Mood Disorders\, and Thomas C. Zachos Chair in Mitochondrial Research. \nHosted by Medicine by Design\, in partnership with the McEwen Stem Cell Institute.  \nTalk title: Brain\, mitochondria & metabolism: A transdiagnostic dimension \nREGISTER HERE\n  \nAbout Ana Andreazza \n\n  \n  \n  \n  \nAs a Professor at the University of Toronto in Pharmacology & Toxicology and Psychiatry\, I hold the Tier II Canada Research Chair in Molecular Pharmacology of Mood Disorders and the Thomas C. Zachos Chair in Mitochondrial Research. I am also the Founder and Scientific Director of the Mitochondrial Innovation Initiative\, a Senior Fellow of Massey College\, and a Member of the Royal Society of Canada College of New Scholars. \nMy research primarily explores the role of mitochondrial function in health and disease\, focusing on neurological and psychiatric disorders\, organ transplant and regeneration\, and novel therapeutics for mitochondrial health improvement. A key area is the study of mitochondrial function in mood disorders like bipolar disorder (BD)\, where I’ve identified dysregulation in mitochondrial genes and are now using 3D brain organoids to investigate neurotransmission impacts. This could lead to personalized treatments for mood and mitochondrial disorders. In organ transplantation\, my work centers on preserving donor organs\, especially lungs\, and improving transplantation outcomes. This involves studying cell metabolism and mitochondrial health\, contributing to better donor-recipient matches and enhancing patient care. I also pioneer in mitochondrial transplantation and therapy\, exploring the stability\, safety\, and efficacy of mitochondria transplant for regenerative medicine and chronic diseases. \nFinally\, my approach integrates cross-disciplinary collaboration\, intertwining mitochondrial function with various health aspects. Leading the Mitochondrial Innovation Initiative\, I drive advances in mitochondrial biology and its health implications\, promoting knowledge exchange and groundbreaking discoveries for patient and societal benefits. \nThis event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room. URL:https://mbd.ccrm.ca/event/global-speaker-series-ana-andreazza-phd/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Global Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20240117T120000 DTEND;TZID=America/Toronto:20240117T130000 DTSTAMP:20231220T162235Z CREATED:20231220T162235Z LAST-MODIFIED:20231220T162235Z UID:33190-1705492800-1705496400@mbd.ccrm.ca SUMMARY:Careers Beyond Academia - Christa Studzinski and Paul Nagy DESCRIPTION:Speakers:\nChrista Studzinski  – Director\, Business Development & Partnerships\, Ontario Brain Institute \nPaul Nagy – Medical Director\, Specialty Care and Oncology\, GSK Canada \n\nCareers Beyond Academia\n“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. For previous recordings of Careers Beyond Academia see here. \nWho Should Attend?\nAttendees should be research trainees‡ who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \n‡ A research trainee is a graduate student\, post-doc\, research associate and/or technician currently working a Canadian lab. \nLearning Objectives:\n\nHelp trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be\nExpose candidates to careers that they might not have previously considered as typical careers in the life sciences\n\n\n\n\n\n\nDate\nConfirmed Speakers\nLink to Register\n\n\n\n\nJanuary 17\, 2024\nChrista Studzinski  – Director\, Business Development & Partnerships\, Ontario Brain Institute \nPaul Nagy – Medical Director\, Specialty Care and Oncology\, GSK Canada\n\n\n\n\nSign up here! URL:https://mbd.ccrm.ca/event/careers-beyond-academia-christa-studzinski-and-paul-nagy/ CATEGORIES:Career Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20231206T083000 DTEND;TZID=America/Toronto:20231206T180000 DTSTAMP:20230912T130123Z CREATED:20230823T190308Z LAST-MODIFIED:20230912T130123Z UID:20808-1701851400-1701885600@mbd.ccrm.ca SUMMARY:8th Annual Symposium: Intentional Innovation DESCRIPTION: URL:https://mbd.ccrm.ca/event/8th-annual-symposium-intentional-innovation/ LOCATION:MaRS Auditorium\, 101 College Street\, Toronto\, Ontario\, M5G 1L7\, Canada CATEGORIES:Symposium END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20231115T120000 DTEND;TZID=America/Toronto:20231115T130000 DTSTAMP:20230921T181944Z CREATED:20230824T141215Z LAST-MODIFIED:20230921T181944Z UID:20816-1700049600-1700053200@mbd.ccrm.ca SUMMARY:Careers Beyond Academia - Ursula Nosi and Shivali Joshi DESCRIPTION:Speakers:\nUrsula Nosi\, PhD – Scientist I – Process Development\, BlueRock Therapeutics\nShivali Joshi\, PhD – Development Manager\, OmniaBio \nREGISTER HERE\n\nCareers Beyond Academia\n“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. View previous recordings of Careers Beyond Academia here. \nWho Should Attend?\nAttendees should be research trainees‡ who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \n‡ A research trainee is a graduate student\, post-doc\, research associate and/or technician currently working a Canadian lab. \nLearning Objectives:\n\nHelp trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be\nExpose candidates to careers that they might not have previously considered as typical careers in the life sciences\n\nREGISTER HERE URL:https://mbd.ccrm.ca/event/careers-beyond-academia-3/ CATEGORIES:Career Speaker Series END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20231114T120000 DTEND;TZID=America/Toronto:20231114T130000 DTSTAMP:20231005T173639Z CREATED:20220714T013512Z LAST-MODIFIED:20231005T173639Z UID:17697-1699963200-1699966800@mbd.ccrm.ca SUMMARY:Global Speaker Series: Claudia Fischbach-Teschl\, PhD – Cornell University DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nJoin speaker Claudia Fischbach-Teschl\,  Professor\, Biomedical Engineering\, Cornell University\, Director of Cornell’s Physical Sciences Oncology Center (PSOC) on the Physics of Cancer Metabolism\, and Associate Director of Cornell Nanoscale Science and Engineering Facility (CNF). Read more about Professor Fischbach-Teschl. \nHosted by Medicine by Design\, in partnership with the McEwen Stem Cell Institute. \nTalk title: Physical sciences approaches to analyze tumor-associated ECM dynamics. \nRegister here\nAbout Claudia Fischbach-Teschl \n\n  \nClaudia Fischbach-Teschl is the Stanley Bryer 1946 Professor of Biomedical Engineering at Cornell University and Associate Director of Cornell Nanoscale Science and Engineering Facility (CNF). She received her Ph.D. in Pharmaceutical Technology from the University of Regensburg\, Germany and conducted her postdoctoral work at Harvard University in the Division of Engineering and Applied Sciences. Her lab utilizes engineering tools and strategies to gain a better understanding of how tumor-microenvironment interactions regulate cancer development\, progression\, and therapy resistance with a focus on cell-ECM interactions. She is a fellow of the American Institute for Medical and Biological Engineering (AIMBE)\, the Biomedical Engineering Society\, and the Alexander von Humboldt Foundation in Germany. She is the recipient of the Momentum Mid-Career Award by the Cellular and Molecular Bioengineering Special Interest Group of the Biomedical Engineering Society (BMES) and the inaugural awardee of a Rosalind Franklin Award by the Max Planck Centre for Physics in Medicine in Germany. She is a Senior Editor of Cancer Research\, and serves on the Editorial Board of the ACS journal Biomaterials Science and Engineering and Tissue Engineering. She is an advocate for interdisciplinary cancer research and has written Op-Ed articles on this topic including in Scientific American.  \nTalk abstract \nMicroenvironmental conditions contribute to the pathogenesis of cancer and include altered cellular composition\, extracellular matrix (ECM) deposition\, and mechanical cues. However\, our understanding of the specific mechanisms by which these microenvironmental perturbations impact the development\, progression\, and therapy response of cancer is relatively limited. More intricate models are needed to better understand the complex biochemical and biophysical interactions that drive tumor initiation\, growth\, metastasis\, metabolic adaptation\, and immune evasion. The fields of biomaterials and tissue engineering provide increasingly sophisticated tools and strategies to recapitulate and monitor relevant properties of tumor-microenvironment interactions. These approaches not only bear tremendous potential to advance our current understanding of cancer\, but are also increasingly explored for more clinically relevant drug testing. Indeed\, combining patient-specific cells with engineered culture systems promises to enhance the predictive power of precision medicine pipelines. This talk will highlight specific examples of how the microenvironment regulates the highly dynamic nature of cancer and will outline opportunities and challenges of the field of tumor engineering.  \n This event will be held in-person only at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room. URL:https://mbd.ccrm.ca/event/global-speaker-series-nov-2023/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Global Speaker Series ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20231017T120000 DTEND;TZID=America/Toronto:20231017T130000 DTSTAMP:20230921T134623Z CREATED:20220714T141111Z LAST-MODIFIED:20230921T134623Z UID:17712-1697544000-1697547600@mbd.ccrm.ca SUMMARY:Global Speaker Series: Qizhi Tang\, PhD – University of California\, San Francisco DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Qizhi Tang\, PhD. Professor Tang is a professor of surgery in the Division of Transplant Surgery and director\, Transplantation Research Laboratory from the University of California\, San Francisco. Learn more about the Tang lab. \nRegister for in-person\nThis event will be held in person at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room. \nTalk title: Helping pancreatic beta cells survive after transplant \n\nAbout Qizhi Tang \n\n  \nDr. Qizhi Tang is a professor of immunology in the UCSF Diabetes Center\, the Department of Surgery\, the Gladstone Institute of Genomic Immunology\, and the Institute of Regenerative Medicine at the University of California\, San Francisco (UCSF). She studied medicine at Peking Union Medical College. After a 6-month research internship during year 5 of the 8-year MD program\, she left the program to pursue graduate study in the US. She studied viral immunology at the University of Illinois in Chicago for her PhD. For her postdoctoral fellowship\, she studied cellular and molecular mechanisms of immune tolerance under the tutelage of Jeffrey bluestone\, first at the University Chicago and then at UCSF. She served as the director of the UCSF Transplantation Research Lab for 14 years from 2007 to 2021. She is currently the director of the Northern California JDRF Center of Excellence. \nOne major research focus in the Tang Lab has been on investigating regulatory T cell control of autoimmune diabetes and transplant rejection. In the past 10 years\, she has led translational efforts to design and implement 10 Treg-based clinical trials in autoimmune diseases and organ transplantation. Currently\, pre-clinical research in her lab focuses on developing cellular engineering strategies to enhance human Treg potency and stability. Another area of research in the Tang lab is to optimize beta cell replacement therapy for type 1 diabetes by improving islet survival in ischemia and designing strategies to avoid immune rejection without systemic immunosuppression. \nTalk abstract \nPancreatic beta cell replacement therapy has the potential to cure type 1 diabetes by replacing lost beta cells.  The therapy is limited by the poor survival of the transplanted cells and the need for life-long immunosuppression.  The presentation will describe ongoing efforts to tackle these challenges using cell engineering strategies. URL:https://mbd.ccrm.ca/event/global-speaker-series-oct-2023/ LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada CATEGORIES:Global Speaker Series ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca END:VEVENT BEGIN:VEVENT DTSTART;TZID=America/Toronto:20231011T120000 DTEND;TZID=America/Toronto:20231011T130000 DTSTAMP:20230926T135356Z CREATED:20230824T141127Z LAST-MODIFIED:20230926T135356Z UID:20814-1697025600-1697029200@mbd.ccrm.ca SUMMARY:Careers Beyond Academia - Allison Bethune and Josee Champagne DESCRIPTION:Speakers:\nAllison Bethune\, MSc – Program Manager\, Harquail Centre for Neuromodulation\, Finance\, Strategy and Sustainability\, Sunnybrook Research Institute \nJosee Champagne\, HBSc\, CCRP – Senior Research Associate\, The Ottawa Hospital; Associate Director\, Clinical Development\, Northern Therapeutics; Director of Clinical Development and Business Development\, weCANreg Consulting Group Inc. \n\nCareers Beyond Academia\n“What are you doing after you graduate?” This is one of the biggest questions facing trainees in the life sciences. Stem Cell Network (SCN) and Medicine by Design have partnered to host Careers Beyond Academia\, a virtual career seminar series that will profile a wide variety of different careers available to trainees who hold a degree in the life sciences. The goal of the series is to help trainees understand the different careers available outside of academia\, the skills required for certain positions\, and some of the daily functions of those positions. \nEach session will feature two speaker presentations that will be recorded and available on SCN’s website and YouTube channel. Trainees will be able to participate in a joint Q&A and panel discussion during the session. For previous recordings of Careers Beyond Academia see here. \nWho Should Attend?\nAttendees should be research trainees‡ who are interested in hearing from professionals working in the life sciences industry and are planning their future career development. Emphasis will be on careers available after a graduate degree (MSc or PhD) in the life sciences\, and particularly in stem cells/regenerative medicine where possible. \n‡ A research trainee is a graduate student\, post-doc\, research associate and/or technician currently working a Canadian lab. \nLearning Objectives:\n\nHelp trainees understand different careers available outside of academia\, what skills are required for those positions\, and what the daily functions of those positions would typically be\nExpose candidates to careers that they might not have previously considered as typical careers in the life sciences\n\n\n\n\n\n\nDate\nConfirmed Speakers\nLink to Register\n\n\n\n\nOctober 11\, 2023\nAllison Bethune\, MSc\, Program Manager\, Harquail Centre for Neuromodulation\, Finance\, Strategy and Sustainability\, Sunnybrook Research Institute \nJosee Champagne\, HBSc\, CCRP\, Senior Research Associate\, The Ottawa Hospital; Associate Director\, Clinical Development\, Northern Therapeutics; Director of Clinical Development and Business Development\, weCANreg Consulting Group Inc.\n\n\n\n\nSign up here! URL:https://mbd.ccrm.ca/event/careers-beyond-academia-2/ CATEGORIES:Career Speaker Series END:VEVENT END:VCALENDAR