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DTSTART;TZID=America/Toronto:20200616T120000
DTEND;TZID=America/Toronto:20200616T130000
DTSTAMP:20260405T165340
CREATED:20191127T180959Z
LAST-MODIFIED:20201203T220705Z
UID:7551-1592308800-1592312400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Ulrich Steidl\, MD\, PhD - Albert Einstein College of Medicine
DESCRIPTION:Medicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Ulrich Steidl\, MD\, PhD\, professor of cell biology and medicine at the Albert Einstein College of Medicine. The title of this talk will be\, “Stem cell heterogeneity and transcription state dynamics in normal and malignant hematopoiesis.” \n  \n \nAbout Ulrich Steidl\nDr. Steidl is the Diane and Arthur B. Belfer Faculty Scholar in Cancer Research\, director of the Stem Cell Isolation and Xenotransplantation Facility\, and a professor of cell biology and of medicine at Albert Einstein College of Medicine\, and associate chair for translational research in oncology at Montefiore Medical Centre. \nThe Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians.
URL:https://mbd.ccrm.ca/event/global-speaker-series-ulrich-steidl-june-2020/
LOCATION:Online
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20200218T120000
DTEND;TZID=America/Toronto:20200218T130000
DTSTAMP:20260405T165340
CREATED:20191127T175612Z
LAST-MODIFIED:20200130T202459Z
UID:7543-1582027200-1582030800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Stuart Forbes\, MB\, ChB - University of Edinburgh
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians.  \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute and the Ontario Institute for Regenerative Medicine\, is pleased to welcome Stuart Forbes\, MB\, ChB\, director of the Centre for Regenerative Medicine and professor of transplantation and regenerative medicine at the University of Edinburgh\, and consultant hepatologist at the Scottish Liver Transplant Unit. He will give a talk titled\, “Developing regenerative therapies for the damaged liver.” \n\nDownload event poster\nThe event will be livestreamed (link will be live shortly before event)\n\n  \nTalk Abstract\nThe normal liver regenerates well after injury but in severe or chronic damage the regeneration capability begins to fail and cellular senescence develops. We have studied human liver injury and regeneration to develop mouse models that develop epithelial senescence and model human disease. This has revealed plasticity between the biliary and hepatocyte population. The epithelial senescence also drives liver pathology such as fibrosis and can be targeted using small molecule approaches. \nBased upon our studies of liver injury and regeneration we have been developing cell therapies for liver disease including macrophage cell therapy for liver cirrhosis which is now in phase 2. \n  \nBiography\nStuart Forbes is Professor of Transplantation and Regenerative Medicine\, at the University of Edinburgh and the Scottish Liver Transplant Unit. His research focuses on how the chronically damaged liver regenerates and how these mechanisms process becomes deranged in liver and bile duct cancer. Prof. Forbes is Director of the MRC Centre for Regenerative Medicine\, University of Edinburgh which houses 230+ scientists and clinicians. He is Director of the UK wide UKRMP Hub for engineering and exploiting the stem cell niche which aims to exploit the biology of stem cell niches for translational benefit. Prof. Forbes is a consultant Hepatologist at the Scottish Liver Transplant Unit\, Royal Infirmary of Edinburgh and has clinical interests in liver failure\, cancer and transplantation and is running phase 1 and 2 trials of macrophage cell therapy for liver cirrhosis.
URL:https://mbd.ccrm.ca/event/global-speaker-series-stuart-forbes-february-2020/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20200121T120000
DTEND;TZID=America/Toronto:20200121T130000
DTSTAMP:20260405T165340
CREATED:20191127T174717Z
LAST-MODIFIED:20200110T222642Z
UID:7536-1579608000-1579611600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Naomi Leonard\, PhD - Princeton University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute and the Ontario Institute for Regenerative Medicine\, is pleased to welcome Naomi Leonard\, PhD\, Edwin S. Wilsey Professor in the Department of Mechanical and Aerospace Engineering at Princeton University. She will deliver a talk titled “Resilience and the Dynamics of Spreading Processes“. \n\nDownload poster\nLivestream talk (NOTE: Medicine by Design’s YouTube channel will go live just before the talk begins)\n\n  \nTalk Abstract\nSpreading processes impact biological\, social\, and technological systems. To systematically derive testable predictions and the means to manage spreading\, models are needed that predict spreading dynamics in terms of a few parameters. We study a spreading model in which interacting agents can adjust their susceptibility to the spreading process after first exposure. The model is motivated by an investigation of regulation of foraging by desert harvester ants. Using an analytically tractable model that predicts behaviors exhibited in field data\, we show how resilience of colony foraging rates to changing temperature and humidity can be explained by ants modifying their susceptibility to the spread of foraging\, once exposed to outside conditions. To generalize these results\, we propose and analyze a network contagion model with adjustable susceptibility and agent heterogeneity. We show how four dynamic regimes are distinguished by four numbers that depend on network structure and heterogeneity. In the bi-stable regime\, not captured in traditional models\, there can be a rapid cascade after a long period of quiescence. We show further how our results allow for systematic design of control strategies to suppress or promote spreading. \nThis is joint work with Renato Pagliara and (for the ant foraging study) Deborah Gordon. \nBiography\nNaomi Ehrich Leonard is Edwin S. Wilsey Professor of Mechanical and Aerospace Engineering and associated faculty in Applied and Computational Mathematics at Princeton University.  She is affiliated with the Program in Quantitative and Computational Biology and the Princeton Neuroscience Institute.  Naomi is a control theorist whose work involves analysis and design of feedback and interconnection in complex\, dynamical systems.  She uses mathematical models to study mechanisms of collective motion and collective decision-making for multi-agent systems in biology and in engineering.  She has applied her work to animal group at many scales as well as to rule-based improvisational dance.  She led a multidisciplinary ocean sensing project with a month-long deployment of an automated\, adaptive network of underwater robotic vehicles in Monterey Bay\, CA.  She received her BSE in Mechanical Engineering from Princeton University and her PhD in Electrical Engineering from the University of Maryland.  She is a MacArthur Fellow\, and Fellow of the American Academy of Arts and Sciences\, SIAM\, IEEE\, IFAC\, and ASME. \n\nLearn more
URL:https://mbd.ccrm.ca/event/global-speaker-series-naomi-leonard-phd-january-2020/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20191119T120000
DTEND;TZID=America/Toronto:20191119T130000
DTSTAMP:20260405T165340
CREATED:20181210T172653Z
LAST-MODIFIED:20191126T154104Z
UID:6168-1574164800-1574168400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: James Wells\, PhD - Cincinnati Children's Hospital Medical Centre
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome James Wells\, PhD\, director for research\, Division of Endocrinology\, and chief scientific officer\, Center for Stem Cell and Organoid Medicine (CuSTOM) at the Cincinnati Children’s Hospital Medical Centre\, and a professor in the Department of Pediatrics at the University of Cincinnati. He will give a talk titled\, “Using human pluripotent stem cells to study development\, diabetes and digestive disease.” \n\n 	 Download event poster\n 	 This event will be livestreamed (link will be live shortly before event)\n\nBiography\nDr. Wells is an endowed professor of Pediatrics at the Cincinnati Children’s Hospital Medical Center. He is in the Division of Developmental Biology\, is the Director for Basic Research in the Division of Endocrinology and was appointed Chief Scientific Officer of the Center for Stem Cell and Organoid Medicine. \nDr. Wells’ research focuses on the processes by which gastrointestinal and endocrine organs form in the developing embryo and how they maintain systemic metabolic homeostasis postnatally. This work in developmental biology has provided the basis for the efforts to generate human cells and tissues from pluripotent stem cells. His lab pioneered approaches to generate gastrointestinal (GI) tissue organoids of the stomach\, intestine\, and colon from human pluripotent stem cells. Human organoids and mouse models are being used in the lab to study endocrine control of digestion and metabolism\, congenital defects of the digestive tract\, and enteric pathogens. In addition\, Dr. Wells and his colleagues are using organoids as a basis for tissue engineering efforts to generate functional tissues for transplantation. \n Learn more about James Wells
URL:https://mbd.ccrm.ca/event/global-speaker-series-james-wells-november-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20191022T120000
DTEND;TZID=America/Toronto:20191022T130000
DTSTAMP:20260405T165340
CREATED:20181210T172224Z
LAST-MODIFIED:20200424T173347Z
UID:6166-1571745600-1571749200@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Karen Christman\, PhD - University of California\, San Diego
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Karen Christman\, PhD\, a professor of bioengineering at the Sanford Consortium for Regenerative Medicine at the University of California\, San Diego. She will give a talk titled\, “Decellularized extracellular matrix based hydrogels for regenerative engineering.” \n Download event poster\n This event will be livestreamed (link will be live shortly before event) \nTalk Abstract\nThe extracellular matrix (ECM) is nature’s scaffold\, and in recent years\, researchers have isolated these scaffolds for tissue engineering applications by removing the cellular components\, a process called decellularization. These scaffolds are known to promote cell influx\, regeneration\, and healing in a variety of tissues\, and their degradation products have angiogenic\, chemoattractant\, and antimicrobial properties\, as well as promote cell proliferation. By removal of the cellular antigens\, these scaffolds are considered biocompatible\, and xenogeneic sources can be used. While these scaffolds retain the native ECM structure\, they are not amenable to minimally invasive\, injectable procedures.  We have developed a variety of injectable ECM derived hydrogels that self-assemble to form porous\, nanofibrous scaffolds once injected in vivo or brought to physiological conditions in vitro.  These ECM based scaffolds have been shown to increase tissue specific differentiation and maturation of a variety of progenitor and stem cells in vitro\, and are showing promise in vivo in several tissues including the myocardium and skeletal muscle.  This talk will cover the recent progress with these materials including the first clinical trial in myocardial infarction patients. \nBiography\nDr. Christman is a Professor in the Department of Bioengineering in the Jacobs School of Engineering at UC San Diego.  She received her B.S. in Biomedical Engineering from Northwestern University in 2000 and her Ph.D. from the University of California San Francisco and Berkeley Joint Bioengineering Graduate Group in 2003\, where she examined in situ approaches to myocardial tissue engineering.  She was also a NIH postdoctoral fellow at the University of California\, Los Angeles in the fields of polymer chemistry and nanotechnology.  Dr. Christman joined the Department of Bioengineering in 2007 and is a member of the Institute of Engineering in Medicine at the University of California\, San Diego.  Her lab\, which is housed in the Sanford Consortium for Regenerative Medicine\, focuses on developing novel biomaterials for tissue engineering and regenerative medicine applications\, and has a strong translational focus with the main goal of developing minimally invasive therapies for cardiovascular disease and women’s health.  Dr. Christman is a fellow of the American Heart Association and the American Institute for Medical and Biological Engineering\, and has received several awards including the NIH Director’s New Innovator and Transformative Research Awards\, the Wallace H. Coulter Foundation Early Career Translational Research Award\, the American Heart Association Western States Innovative Sciences Award\, and the Tissue Engineering and Regenerative Medicine Society’s Young Investigator and Senior Scientist Awards.  Dr. Christman is also co-founder of Ventrix\, Inc.\, which has completed a Phase I clinical trial and is currently planning a Phase II trial with the cardiac extracellular matrix hydrogel technology developed in her lab at UC San Diego. \n Learn more about Karen Christman
URL:https://mbd.ccrm.ca/event/global-speaker-series-karen-christman-october-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190917T120000
DTEND;TZID=America/Toronto:20190917T130000
DTSTAMP:20260405T165340
CREATED:20181210T171838Z
LAST-MODIFIED:20191126T154223Z
UID:6164-1568721600-1568725200@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Guo-Li Ming\, MD\, PhD - University of Pennsylvania
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Guo-Li Ming\, MD\, PhD\, professor of neuroscience at the Perelman School of Medicine\, University of Pennsylvania. She will give a talk titled\, “Brain-Region-Specific Organoids for Modeling Neurodevelopment and Disease.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\nTalk Abstract\nThree dimensional (3D) organoid cultures from human iPSCs have been recently developed to recapitulate the development and resemble the cytoarchitecture of various organs. Human brain is probably the most complex organ in the human body.  Several proof of principle studies demonstrate that human brain organoids can serve as a unique experimental model to probe the molecular and cellular mechanisms underlying the human brain development and to model neurodevelopmental disorders\, such as microcephaly and autism. We have developed various protocols to produce brain-region specific organoids derived from human iPSCs using a novel miniaturized spinning bioreactor\, including forebrain\, midbrain and hypothalamus organoids.  I will present our recent progress on using these organoids as model systems to study human neurogenesis. \nLearn more about Guo-Li Ming
URL:https://mbd.ccrm.ca/event/global-speaker-series-guo-li-ming-september-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190718T120000
DTEND;TZID=America/Toronto:20190718T130000
DTSTAMP:20260405T165340
CREATED:20190610T150117Z
LAST-MODIFIED:20191126T154434Z
UID:6713-1563451200-1563454800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Shulamit Levenberg\, PhD — Technion-Israel Institute of Technology
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Shulamit Levenberg\, PhD\, Dean of the Faculty of Biomedical Engineering at Technion-Israel Institute of Technology and the inaugural Medicine by Design Scholar in Residence. The title of her talk is “Vascularization Dynamics in Engineered Tissues.” \n\nDownload event poster\n\nBiography\nProfessor Shulamit Levenberg is the elected Dean of the Biomedical Engineering Department at the Technion. She also serves as the director of the Technion Center for 3D Bioprinting and The Rina & Avner Schneur Center for Diabetes Research. Professor Levenberg earned her PhD at the Weizmann Institute of Science\, where she focused on cell adhesion dynamics and signaling\, and pursued her post-doctoral research in tissue engineering at MIT\, in the lab of Professor Robert Langer. In 2004\, she joined the Technion Faculty of Biomedical Engineering where she conducts interdisciplinary research on stem cells and tissue engineering. She spent a sabbatical year (2011-2012) as a visiting professor at the Wyss Institute for Biology Inspired Engineering at Harvard University and a summer sabbatical (2017) at the University of Western Australia as a winner of the Raine Visiting Professor Award. Professor Levenberg received the Krill Prize for excellence in scientific research\, awarded by the Wolf Foundation\, and was named by Scientific American as a “Research Leader” in tissue engineering\, for her seminal work on vascularization of engineered tissues. She also received the France-Israel Foundation Prize\, the Italian Excellence for Israel Prize\, the Teva Research Prize and the Juludan Prize. In 2018\, she received the Rappaport Prize for Biomedical Sciences. Professor Levenberg has authored more than 100 publications\, and presented her work in over 100 international conferences as an invited or keynote speaker. She is founder and chief scientific officer of two start-up companies in the areas of cultured meat and nanoliter arrays for rapid antimicrobial susceptibility testing.  She is a member of the Israel National Counsel for Bioethics and is actively involved in training young scientists.
URL:https://mbd.ccrm.ca/event/global-speaker-series-shulamit-levenberg-july-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190618T120000
DTEND;TZID=America/Toronto:20190618T130000
DTSTAMP:20260405T165340
CREATED:20190510T164043Z
LAST-MODIFIED:20191126T154411Z
UID:6590-1560859200-1560862800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Kevin Chalut\, PhD — University of Cambridge
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Kevin Chalut\, PhD\, a Royal Society University Research Fellow\, Cavendish Laboratory\, at the University of Cambridge and principal investigator in the Cambridge Stem Cell Institute. He will give a talk titled\, “Mechanical signalling and cell fate.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\n  \nTalk Abstract\nThe role of mechanical signaling in cell fate choice has been largely overlooked; however\, it plays a significant role in tuning cellular response to signals. My lab is investigating the interplay between biochemical signaling and mechanical signaling in cell fate decisions. I will show first in the mouse embryo that biochemical signaling modulates cytoskeletal contractility to influence spatial positioning and solidify cell fate choice. I will then show that mechanics tunes the response of the cell to biochemical signaling to steer fate choice. This hypothetical feedback loop between mechanics and biochemical signaling likely has significant impact on cellular plasticity both in development and stem cells. I will also present an example demonstrating the functional impact of mechanics on stem cell function. In this example\, we have shown that we can reverse the loss of plasticity associated with ageing by controlling the mechanical microenvironment. Ultimately\, I will advance the hypothesis that mechanical sensing acts as a switch to modulate growth factor signaling to modulate cell fate choice. \n  \nBiography\nKevin Chalut is a biophysicist with a PhD in Physics from Duke University. He is currently a group leader at the Wellcome Trust-Medical Research Council Stem Cell Institute in Cambridge. \nHis work focuses on using the tools and concepts of physics to study cell fate choice in stem cells and developing organisms. His lab primarily investigates how the mechanical microenvironment regulates fate decisions\, and exactly how cells process information during that fate choice. The ultimate goal of his laboratory is to apply their physics-based techniques to understand how organisms develop\, and also how to use stem cells for therapeutic use.
URL:https://mbd.ccrm.ca/event/global-speaker-series-kevin-chalut-june-2019/
LOCATION:Medical Sciences Building\, Room 2172\, 1 King's College Circle\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190603T120000
DTEND;TZID=America/Toronto:20190603T130000
DTSTAMP:20260405T165340
CREATED:20181210T171351Z
LAST-MODIFIED:20200429T165518Z
UID:6162-1559563200-1559566800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Daniel G. Anderson\, PhD - Massachusetts Institute of Technology
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Daniel G. Anderson\, PhD\, the Samuel A. Goldblith Professor of Applied Biology\, associate professor in the Department of Chemical Engineering and Institute for Medical Engineering and Science\, and a member of the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology. He will give a talk titled\, “Delivery systems for in vivo genome editing and cell therapy.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\nTalk Abstract\nHigh throughput\, combinatorial approaches have revolutionized small molecule drug discovery.  Here we describe our work on the combinatorial development of biomaterials for medical devices ranging from nanoparticulate delivery systems to macroscopic devices.  One focus of our work is on nanoparticulate\, intracellular delivery systems for RNA therapy and gene editing.  Libraries of degradable polymers and lipid-like materials have been synthesized\, formulated and screened for their ability to delivery macromolecular payloads inside of cells.  A number of delivery formulations have been developed with in vivo efficacy\, enabling gene suppression with siRNA\, gene expression with mRNA\, or permanent genetic editing using the CRISPR/Cas9 system.  These formulations show potential therapeutic application for the treatment of disease in both rodent and primate models.  A second focus of our work is on developing biomaterials that can avoid the fibrotic response common to implanted medical devices.  Using combinatorial chemistry\, we have developed new materials capable of avoiding fibrosis and scar tissue formation. These show particular promise as vehicles for the immune-isolation of transplanted cells\, for the treatment of diabetes.  When formulated into microcapsules these materials enable functional\, long-term islet transplantation in immune competent\, diabetic rodents\, as well as normal non-human primates. \nBiography\nLearn more about Daniel G. Anderson
URL:https://mbd.ccrm.ca/event/global-speaker-series-daniel-anderson-june-2019/
LOCATION:Medical Sciences Building\, Room 2172\, 1 King's College Circle\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190507T120000
DTEND;TZID=America/Toronto:20190507T130000
DTSTAMP:20260405T165340
CREATED:20181210T170927Z
LAST-MODIFIED:20191126T153836Z
UID:6160-1557230400-1557234000@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Abhay Pandit\, PhD - National University of Ireland Galway
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Abhay Pandit\, PhD\, established professor in biomaterials at the National University of Ireland Galway. He will give a talk titled\, “Redefining Identity of Disease\, Tissues and Cells: A Biomaterials Paradigm.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\nLearn more about Abhay Pandit
URL:https://mbd.ccrm.ca/event/global-speaker-series-may-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190423T120000
DTEND;TZID=America/Toronto:20190423T130000
DTSTAMP:20260405T165340
CREATED:20181210T165302Z
LAST-MODIFIED:20191126T153901Z
UID:6157-1556020800-1556024400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Cole DeForest\, PhD - University of Washington
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Cole DeForest\, PhD\, an assistant professor in the Department of Chemical Engineering and core faculty at the Institute of Stem Cell & Regenerative Medicine at the University of Washington. He will give a talk titled\, “User-Programmable Hydrogel Biomaterials to Probe and Direct 4D Stem Cell Fate.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\nTalk Abstract\nThe extracellular matrix directs stem cell function through a complex choreography of biomacromolecular interactions in a tissue-dependent manner. Far from static\, this hierarchical milieu of biochemical and biophysical cues presented within the native cellular niche is both spatially complex and ever changing. As these pericellular reconfigurations are vital for tissue morphogenesis\, disease regulation\, and healing\, in vitro culture platforms that recapitulate such dynamic environmental phenomena would be invaluable for fundamental studies in stem cell biology\, as well as in the eventual engineering of functional human tissue. In this talk\, I will discuss some of our group’s recent success in reversibly modifying both the chemical and physical aspects of synthetic cell culture platforms with user-defined spatiotemporal control. Results will highlight our ability to modulate intricate cellular behavior including stem cell differentiation\, protein secretion\, and cell-cell interactions in 4D. \nBiography\nLearn more about Cole DeForest
URL:https://mbd.ccrm.ca/event/global-speaker-series-cole-deforest-april-2019/
LOCATION:Mount Sinai Hospital\, Ben Sadowski Auditorium\, 18th floor\, 600 University Avenue\, Toronto\, Ontario\, M5G 1X5\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190307T123000
DTEND;TZID=America/Toronto:20190307T133000
DTSTAMP:20260405T165340
CREATED:20181210T164335Z
LAST-MODIFIED:20191126T153958Z
UID:6154-1551961800-1551965400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Weian Zhao\, PhD - University of California\, Irvine
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Weian Zhao\, PhD\, associate professor at the Sue and Bill Gross Stem Cell Research Center\, Chao Family Comprehensive Cancer Center\, and Department of Pharmaceutical Sciences at the University of California\, Irvine. He will give a talk titled\, “Bioengineering technologies for next generation stem cells and immunotherapies.” \n Download event poster \n This event will be livestreamed (link will be live shortly before event) \nLearn more about Weian Zhao
URL:https://mbd.ccrm.ca/event/global-speaker-series-weian-zhao-march-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190122T120000
DTEND;TZID=America/Toronto:20190122T130000
DTSTAMP:20260405T165340
CREATED:20181210T163443Z
LAST-MODIFIED:20191126T154151Z
UID:6151-1548158400-1548162000@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Peter Reddien\, PhD - Massachusetts Institute of Technology
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Peter Reddien\, PhD\, a professor in the Department of Biology at the Massachusetts Institute of Technology. He will give a talk titled\, “The essential components of regeneration.” \nDownload event poster \nThis event will be livestreamed (link will be live shortly before event) \nTalk Abstract\nHow animals regenerate missing body parts is one of the great mysteries of biology. Planarians are flatworms capable of some of the most dramatic known feats of animal regeneration\, including regeneration of new heads. We have uncovered a key set of minimal components and concepts needed to explain how these animals accomplish their regenerative feats. \nBiography\nLearn more about Peter Reddien
URL:https://mbd.ccrm.ca/event/global-speaker-series-peter-reddien-january-2019/
LOCATION:Mount Sinai Hospital\, Ben Sadowski Auditorium\, 18th floor\, 600 University Avenue\, Toronto\, Ontario\, M5G 1X5\, Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181120T120000
DTEND;TZID=America/Toronto:20181120T130000
DTSTAMP:20260405T165340
CREATED:20180820T150235Z
LAST-MODIFIED:20191126T153521Z
UID:5670-1542715200-1542718800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Marlene Rabinovitch\, MD\, Stanford University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Marlene Rabinovitch\, MD\, the Dwight and Vera Dunlevie Professor in Pediatric Cardiology at Stanford University. She will give a talk titled\, “Impact of shear stress on chromatin accessibility and gene regulation.” \nDownload poster \nThis talk will be be live streamed \nTalk Abstract\nIt is well known that laminar shear stress as opposed to static or disturbed flow induces vasculoprotective endothelial (EC) genes such as endothelial nitric oxide synthase (eNOS)\, but how changes in flow affect chromatin accessibility at specific transcription factor binding sites is not known. We used the Ibidi flow system with cultured pulmonary arterial (PA) EC and applied ATAC Seq\, ChIPSeq and RNA Seq to determine why certain regions of chromatin open and others close to regulate a distinct program of gene expression. We determined by mass spectrometry and proximity ligation analysis that KLF4 interacts with the Brg complex of chromatin remodelers under laminar flow to regulate genes that protect endothelial cells and that ATF2 interacts with the Brg complex of chromatin remodelers under static or disturbed flow\, to regulate genes that can perturb endothelial function and lead to a pro-inflammatory milieu. We harvested EC from patients with pulmonary arterial hypertension (PAH) associated with a congenital heart defect but could not observe a phenotype that distinguished these from control EC under static or laminar flow conditions.  Based upon computer modeling of a congenital heart defect with PAH\, we subjected the EC to high shear\, 100 or 170 dynes cm2.  In both cases we saw evidence of high eNOS and eNOS un-coupling resulting in an increase in reactive oxygen species (ROS). RNA sequencing revealed increased cholesterol biosynthesis and activation of GTPase that can alter caveoli and result in eNOS uncoupling\, ROS production and perturbation of normal endothelial cell function. \nBiography\nDr. Rabinovitch is the Dwight and Vera Dunlevie Professor in Pediatric Cardiology\, at Stanford University School of Medicine. Dr. Rabinovitch graduated from McGill University Medical School and completed her pediatrics training at the University of Colorado and sub-specialty training in cardiology at Boston Children’s Hospital\, Harvard Medical School\, where she was Assistant Professor. She then became Professor of Pediatrics\, Laboratory Medicine and Pathobiology and Medicine at the University of Toronto\, Director of the Cardiovascular Research Program at the Hospital for Sick Children and the Robert M. Freedom/Heart and Stroke Foundation Chair. \nDr. Rabinovitch has received numerous awards for her research and mentoring. These include: \n\n2017: the American Heart Association Distinguished Scientist Lecturer;\n2016: the prestigious J. Burns Amberson Lectureship from the American Thoracic Society\, and the Robert F. Grover Prize from the Assembly on Pulmonary Circulation;\n2015: Mentorship Awards from the Association for Women in Science and the Stanford Department of Pediatrics;\n2012: the Judith Pool Mentorship Award;\n2010: the Louis and Artur Lucian Award for Research in Circulatory Diseases from McGill University:\n2008: the Recognition Award for Scientific Accomplishment from ATS;\n2006: the American Heart Association’s (AHA) Distinguished Scientist Award;\n2004: AHA’s Basic Research Prize\, and the Canadian Institute of Circulatory and Respiratory Health Lectureship and Prize; and\n2003: the Gill Heart Institute Award for Outstanding Contributions to Cardiovascular Research.\n\nShe has given numerous named lectureships\, including the AHA Paul Dudley White and Dickinson Richards Lectures\, as well as the American Physiological Society Julius Comroe Lecture. She has served as Visiting Professor in many countries worldwide and has over 190 peer-reviewed publications and 124 invited reviews and book chapters. \nDr. Rabinovitch is currently the Director of the Basic Science and Engineering Initiative of the Betty Irene Moore Children’s Heart Center at Stanford University. In addition\, she is the Associate Director in Basic Research at Stanford’s Cardiovascular Institute and on the Executive Committee of the Pulmonary Vascular Research Institute. She has recently served as an External Advisor to the NHLBI Lung Regeneration Program\, the Max Planck Institute for Heart and Lung Research and the German Lung Centers of Excellence\, and has also served on the Scientific Advisory Councils of NHLBI as well as numerous other Research Foundations. She is a member of the American Society for Clinical Investigation\, and the Association of American Physicians\, and has been Associate Editor of Circulation Research and Annual Reviews of Physiology. Her research focuses on uncovering fundamental genetic\, metabolic\, and inflammatory mechanisms causing pulmonary hypertension that can be translated to the clinic.
URL:https://mbd.ccrm.ca/event/global-speaker-series-marlene-rabinovitch-november-2018/
LOCATION:Mount Sinai Hospital\, Ben Sadowski Auditorium\, 18th floor\, 600 University Avenue\, Toronto\, Ontario\, M5G 1X5\, Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181016T120000
DTEND;TZID=America/Toronto:20181016T130000
DTSTAMP:20260405T165340
CREATED:20180814T224231Z
LAST-MODIFIED:20191126T153439Z
UID:5570-1539691200-1539694800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Jennifer Elisseeff\, PhD\, Johns Hopkins University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Jennifer Elisseeff\, PhD\, Professor and Director\, Translational Tissue Engineering Center\, Wilmer Eye Institute and departments of Biomedical Engineering\, Orthopedic Surgery\, Chemical and Biological Engineering\, and Materials Science and Engineering at Johns Hopkins University. The title of her talk is “Lessons from translation and the development of regenerative immunotherapies”. \nDownload event poster \nThis talk will be be live streamed \nAbstract\nThe immune system is the first responder to trauma and foreign bodies such as biomaterials\, yet this response and its capacity to orchestrate tissue repair has been largely ignored. Today\, biomaterials can be engineered with exquisite control over physical properties and can present an array of spatially controlled biological cues. Until now\, these scaffolds have directly targeted stem cells\, vascular development\, and differentiated cells to stimulate tissue formation or wound healing. Translating tissue engineering technologies to the clinic\, we discovered cells from adaptive immune system responded to the biomaterials. We profiled in depth the immunological response to the wound environment in combination with biological scaffolds. The adaptive immune system\, specifically Th2 T cells\, is required for the scaffold stimulation of wound repair. We are now investigating in detail the innate and adaptive immune response to synthetic versus biological scaffolds and possible candidates for tissue stroma-immune regulation. In parallel\, we are exploiting these discoveries to design immunomodulatory materials for tissue repair. Ultimately\, targeting the immune system represents a paradigm shift for the field and will help to realize the promise of regenerative medicine. \nBiography\nJennifer Elisseeff is the Morton Goldberg Professor and Director of the Translational Tissue Engineering Center at Johns Hopkins University’s Department of Biomedical Engineering and the Wilmer Eye Institute\, with appointments in Chemical and Biological Engineering\, Materials Science and Orthopedic Surgery. She was elected a Fellow of the American Institute of Medical and Biological Engineering\, the National Academy of Inventors\, and a Young Global Leader by World Economic Forum. In 2018\, she was elected to the National Academy of Engineering. \nJennifer received a bachelor’s degree in chemistry from Carnegie Mellon University and a PhD in medical engineering from the Harvard–MIT Division of Health Sciences and Technology. Later she was a Fellow at the National Institute of General Medical Sciences\, Pharmacology Research Associate Program\, where she worked in the National Institute of Dental and Craniofacial Research. She has published over 200 papers\, book chapters\, and patent applications and received a number of awards including the Carnegie Young Alumni Award. In 2002\, she was named by MIT Technology Review as a top innovator under 35. \nJennifer’s research focus is the development of biomaterials for regenerative medicine applications in orthopedics\, plastic and reconstructive surgery\, and ophthalmology.  She is now studying biomaterials-directed regenerative immunology and the role of the adaptive immune system in tissue repair.  She is committed to the translation of regenerative biomaterials and has founded several companies and participates in several industry advisory boards.
URL:https://mbd.ccrm.ca/event/global-speaker-series-2018-october/
LOCATION:Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180918T120000
DTEND;TZID=America/Toronto:20180918T130000
DTSTAMP:20260405T165340
CREATED:20180814T224618Z
LAST-MODIFIED:20191126T153657Z
UID:5573-1537272000-1537275600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Ke Cheng\, PhD\, North Carolina State University/UNC-Chapel Hill
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Ke Cheng\, PhD\, associate professor in the Department of Molecular and Biomedical Sciences at North Carolina State University’s College of Veterinary Medicine and associate professor in the joint Department of Biomedical Engineering at North Carolina State University and the University of North Carolina at Chapel Hill. The title of his talk is “Cell Therapy by Design: Biomaterials and Bioengineering Approaches for More Potent Cell Therapies”. \nDownload event poster \nThis talk will be be live streamed \nAbstract\nNo therapy currently available can reduce the size of an established scar on the heart. Cell therapy aims to alter this fixed trajectory for MI survivors: to intervene adverse heart remodelling\, to reduce scar size\, and to actually regenerate viable myocardial tissue. The last one and half decades witnessed the booming of stem cell therapies for multiple diseases. Our lab has been studying stem cell therapy for heart regeneration in the past decade. Efficacy in cell transplantation is hampered by many hurdles\, including low rates of cell retention and engraftment\, poor targeting to the injury site\, and unstable cell quality during long-term storage. We have developed multiple ​bioengineering strategies to enhance the delivery of stem cells. In addition\, we have been studying alternative mechanisms that can explain the extravasation of injected cells. \nBiography\nDr. Ke Cheng is professor of biomedical engineering and veterinary medicine at UNC-Chapel Hill and NC State University\, where he also serves as the associate director of the Comparative Medicine Institute. His research focuses on stem cells\, biomaterials and nanomedicine approaches for regenerative medicine applications. More particularly\, the results from the Cheng lab have translated into new therapies for cardiovascular and pulmonary diseases such as myocardial infarction and pulmonary fibrosis\, including recently completed and ongoing clinical trials in human patients. The lab has been continuously supported by the National Institutes of Health and has published results in journals such as Nature Biomedical Engineering\, Nature Communications\, Circulation Research\, ACS Nano and Theranostics.
URL:https://mbd.ccrm.ca/event/global-speaker-series-2018-september/
LOCATION:Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180619T120000
DTEND;TZID=America/Toronto:20180619T130000
DTSTAMP:20260405T165340
CREATED:20180820T162619Z
LAST-MODIFIED:20191126T153302Z
UID:5701-1529409600-1529413200@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Prisca Liberali\, Friedrich Miescher Institute for Biomedical Research
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Prisca Liberali\, PhD\, from the Friedrich Miescher Institute for Biomedical Research\, affiliated with the University of Basel. The title of her talk is “Self-organization and symmetry breaking in intestinal organoids.” \nDownload poster \nTalk Abstract\nIntestinal organoids are complex three-dimensional structures that mimic cell type composition and tissue organization of the intestine by recapitulating the self-organizing capacity of cell populations derived from a single stem cell. Crucial in this process is a first symmetry-breaking event\, in which only a fraction of identical cells in a symmetrical cyst differentiate into Paneth cells\, which in turn generates the stem cell niche and leads to asymmetric structures such as crypts and villi. We here combine a quantitative single-cell gene expression and imaging approach to characterize the development of intestinal organoids from a single cell. We show that intestinal organoid development follows a regeneration process driven by transient Yap1 activation. Cell-to-cell variability in Yap1\, emerging in symmetrical cysts\, induces a Notch/Dll1 lateral inhibition event driving the symmetry-breaking event and the formation of the first Paneth cell. Our findings reveal how single cells exposed to a uniform growth-promoting environment have the intrinsic ability to generate emergent\, self-organized behavior resulting in the formation of complex multicellular asymmetric structures.
URL:https://mbd.ccrm.ca/event/global-speaker-series-prisca-liberali-june-2018/
LOCATION:Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180515T120000
DTEND;TZID=America/Toronto:20180515T130000
DTSTAMP:20260405T165340
CREATED:20180820T162954Z
LAST-MODIFIED:20191126T152730Z
UID:5703-1526385600-1526389200@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Jared Toettcher\, PhD\, Princeton University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Jared Toettcher\, PhD\, assistant professor of molecular biology at Princeton University. \nDownload event poster \nLivestream talk (link will be live shortly before event) \nPlease check back soon for more details.
URL:https://mbd.ccrm.ca/event/global-speaker-series-jared-toettcher-may-2018/
LOCATION:Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180426T120000
DTEND;TZID=America/Toronto:20180426T130000
DTSTAMP:20260405T165340
CREATED:20180320T214324Z
LAST-MODIFIED:20191125T220911Z
UID:5049-1524744000-1524747600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Michael Levin\, PhD\, Tufts University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Michael Levin\, PhD\, Vannevar Bush Professor in the Department of Biology at Tufts University and director of both the Allen Discovery Center at Tufts University and the Tufts Center for Regenerative and Developmental Biology. His talk title is “Cracking the bioelectric code: Targeting endogenous physiological networks for advances in regenerative medicine and synthetic bioengineering.” \nDownload event poster \nLive stream the talk (link will be live shortly before the talk begins) \nAbstract \nA key property of living tissues is their ability to perform pattern homeostasis: harnessing individual cell behaviours toward creation and repair of complex anatomies during embryogenesis and regeneration. How can the decision-making abilities of cells be targeted for advances in regenerative medicine and synthetic bioengineering? Our group has discovered that an important aspect of information processing at the tissue and organ level occurs via endogenous bioelectrical signalling: spatio-temporal patterns of resting potential (across all cells\, not just neurons) that store and process pattern memories that help direct growth and form. In this talk\, I will explain the basics of non-neural bioelectricity\, illustrate the new molecular techniques we have developed to read and write patterning information into tissues\, and show examples of the control of large-scale pattern by specific modulation of patterns of resting potential. Recent examples include reprogramming of tumours\, converting gut tissue into complete eyes\, induction of appendage regeneration\, innervation control\, and repair of teratogen- and mutation-induced birth defects. While we have identified transduction machinery and transcriptional targets of bioelectric change in single cells\, the biggest open questions concern computationally understanding the dynamics of large-scale bioelectric circuits for pattern control. I will conclude the talk with a perspective on the exciting opportunities in synthesizing machine learning and electroceutical compounds for advances in regenerative repair\, cancer normalization and synthetic morphology. \nBiography \nMike Levin is a professor in the Department of Biology at Tufts University\, holding the endowed Vannevar Bush Chair and serving as director of the Allen Discovery Center at Tufts. He began as a software engineer\, working in scientific programming and artificial intelligence. He then received two B.S. degrees (in computer science and Biology) at Tufts University\, and then went on to a PhD with Cliff Tabin (Harvard Medical School)\, in which they identified the genetic cascade responsible for consistent left-right asymmetry of the embryonic heart and viscera. In his post-doc with Mark Mercola (also at Harvard Medical School)\, he identified a physiological system of long-range signalling upstream of the transcriptional cascades determining embryonic laterality. He started his own group in 2000 at the Forsyth Institute (Harvard School of Dental Medicine)\, focusing on building new molecular tools to read and control the bioelectrically mediated processing of patterning information in embryogenesis and regeneration. He moved his team to the main campus at Tufts in 2009\, to be closer to collaborators in diverse fields. Currently\, his group uses computational and molecular-genetic techniques at the intersection of developmental biophysics\, primitive cognition and machine learning. They use model systems including embryonic frog\, regenerating flatworms\, Physarum slime molds\, and human cells to understand information processing and computation in a wide range of living systems.
URL:https://mbd.ccrm.ca/event/global-speaker-series-michael-levin-april-2018/
LOCATION:Leslie Dan Faculty of Pharmacy\, Room 850\, 144 College Street\, Toronto\, Ontario\, M5S 3M2\, Canada
CATEGORIES:Global Speaker Series
ATTACH;FMTTYPE=image/jpeg:https://mbd.ccrm.ca/wp-content/uploads/2017/09/MBD-Symposium-full-87-720x480.jpg
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180326T123000
DTEND;TZID=America/Toronto:20180326T133000
DTSTAMP:20260405T165340
CREATED:20180820T153115Z
LAST-MODIFIED:20191126T153246Z
UID:5677-1522067400-1522071000@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Eric Siggia\, PhD\, Rockefeller University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Eric Siggia\, PhD\, the Viola Ward Brinning and Elbert Calhoun Brinning Professor at Rockefeller University. The title of his talk is “Microcolonies of Human Embryonic Stem Cells as Models of Early Embryonic Patterning.” \nDownload event poster \nLive stream talk (link will be live shortly before the event)
URL:https://mbd.ccrm.ca/event/global-speaker-series-eric-siggia-march-2018/
LOCATION:Medical Sciences Building\, Room 2170\, 1 King's College Circle\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180220T120000
DTEND;TZID=America/Toronto:20180220T130000
DTSTAMP:20260405T165340
CREATED:20180820T161012Z
LAST-MODIFIED:20191126T153223Z
UID:5689-1519128000-1519131600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Princess Imoukhuede\, PhD\, University of Illinois at Urbana-Champaign
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Princess Imoukhuede\, PhD\, assistant professor of bioengineering at the University of Illinois at Urbana-Champaign. Professor Imoukhuede will deliver a talk on Systems Biology: Recipes for Advancing Predictive Biology. \nDownload event poster \nLive stream talk (link will be live shortly before the event) \nTalk Abstract\nDirected control of angiogenesis can improve the treatment of over 70 diseases. We hypothesize that such control can be reached by computationally integrating two types of parameters: protein concentrations and protein-protein interaction (PPI) kinetics. In support of this hypothesis\, we report three key advancements: (1) engineering of new quantitative fluorescent nanosensors (qFluors) to measure plasma membrane vascular endothelial growth factor receptor (VEGFR) (Fig. 1) and platelet derived growth factor receptor (PDGFR) concentrations and heterogeneity; (2) discovery and measurement of new cross-family interactions between PDGFs and VEGFR2 (Fig. 2); and (3) development of computational models that accurately predict VEGFR-mediated protein phosphorylation\, cell proliferation\, and cell migration (Fig. 3). \nOur approaches are advancing us towards the goal of directing the growth factor receptor signaling that underlies angiogenesis. Firstly\, our qFluors are establishing a new method for quantifying biomarker heterogeneity\, which can be translated to clinical pathology. More immediately\, this approach is providing the receptor concentration data necessary for accurate computational model development. Additionally\, our discovery and measurement of cross-family binding represents a paradigm shift\, where PPI interaction kinetics\, not family\, define our view of protein function. More immediately\, these kinetic measurements provide the necessary data for predicting cell responses. Finally\, our computational models are integrating each of the parameters and providing validated predictions of angiogenic cell response. \nThis material is based upon work supported by the National Science Foundation (NSF)\, American Heart Association (AHA)\, and American Cancer Society (ACS) under Grant #s: NSF CBET: 1512598; NSF CAREER: 1653925; NSF BPE:1648454; AHA:16SDG26940002; and ACS-IL: 282802 \nBiography\nProfessor Imoukhuede earned her SB in Chemical Engineering from the Massachusetts Institute of Technology (MIT) where her research earned her the coveted Class of 1972 award\, presented annually to the project that most improves the quality of life through its impact on people and/or the environment. Professor Imoukhuede’s research was funded by the National Science Foundation’s Biotechnology Process Engineering Center at MIT and through a Bioengineering Undergraduate Research Award by the MIT Division of Bioengineering and Environmental Health.\nProfessor Imoukhuede was honored with the 2002 Betsy Schumaker Award (also known as the MIT female athlete of the year)\, was selected to a COSIDA/VERIZON Academic All-America team\, and was awarded an NCAA postgraduate scholarship. Professor Imoukhuede championed the importance of social responsibility in the midst of academic excellence by serving as the President of the MIT Committee on Multiculturalism\, President of the MIT chapter of the American Institute of Chemical Engineers (AIChE)\, and held both chapter and zone offices in the National Society of Black Engineers (NSBE). \nAfter earning her undergraduate degree\, Professor Imoukhuede pursued graduate study in bioengineering at the California Institute of Technology (Caltech) in Pasadena\, CA. Here\, she combined sensitive techniques in biomedical optics with nanoparticle imaging towards understanding the structure\, function\, and trafficking of a key protein in epilepsy\, the GABA transporter\, GAT1. She also performed research in nicotine addiction through molecular imaging of nicotinic acetylcholine receptors. Professor Imoukhuede’s research in nanotechnology earned her the Kavli Nanoscience Institute Award and her graduate research was supported by the National Institutes of Health (NIDA). Professor Imoukhuede was the first African-American woman to be awarded a Bioengineering PhD by Caltech and was only the second African-American woman to earn a PhD from Caltech’s Division of Engineering and Applied Science. \nProfessor Imoukhuede completed a post-doctoral fellowship in the Biomedical Engineering Department at the Johns Hopkins University School of Medicine.  During her fellowship at Johns Hopkins\, she was 1 of ten post-doctoral fellows nationwide to earn the prestigious United Negro College Fund/Merck Postdoctoral Research Fellowship\, 1 of 6 young investigators to earn the FASEB Postdoctoral Professional Development Award\, and her work was awarded a Poster Award at the biennial Gordon Conference in Angiogenesis. Her post-doctoral work was also supported by the National Institutes of Health (NHLBI).
URL:https://mbd.ccrm.ca/event/global-speaker-series-princess-imoukhuede-february-2018/
LOCATION:Canada
CATEGORIES:Global Speaker Series
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180116T120000
DTEND;TZID=America/Toronto:20180116T130000
DTSTAMP:20260405T165340
CREATED:20180820T155649Z
LAST-MODIFIED:20191125T194345Z
UID:5683-1516104000-1516107600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Lee Rubin\, PhD\, Harvard University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Lee Rubin\, PhD\, professor in the Department of Stem Cell and Regenerative Biology at Harvard University. This event will be webcast \nBiography\nLee Rubin received his PhD in Neuroscience from The Rockefeller University and completed postdoctoral fellowships in pharmacology at Harvard Medical School and in neurobiology at Stanford University School of Medicine. He has broad experience in both academia and industry\, particularly in the realms of cell-based assays and drug discovery. Prior to Harvard\, he was chief scientific officer of Curis\, Inc.\, a Cambridge-based biotechnology company\, where his group identified the first small molecule regulators of the hedgehog signalling pathway. One of their antagonists was developed by Genentech and is now (as Erivedge) approved as the first oral treatment for metastatic basal cell carcinoma. At Harvard\, much of Rubin’s work is focused on finding key molecular mediators of different neurodegenerative diseases and on searching for effective pre-clinical therapeutic candidates. His group’s research takes advantage of their ability to produce large numbers of patient-derived induced pluripotent stem cell lines and of effective means of deriving large numbers of differentiated neurons from them. They have set up an array of techniques that allow them to identify early cellular and physiological changes in neurons as they become diseased. For example\, they have identified new targets for the treatment of the motor neuron disorders spinal muscular atrophy and amyotrophic lateral sclerosis. They are also studying autism spectrum disorders\, Parkinson’s disease and Alzheimer’s disease. Recently\, his group discovered that a circulating protein\, GDF11\, has the ability to reverse some of the changes in the central nervous system associated with aging. They are actively exploring the therapeutic implications of these observations.
URL:https://mbd.ccrm.ca/event/global-speaker-series-lee-rubin-january-2018/
LOCATION:Canada
CATEGORIES:Global Speaker Series
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