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DTSTART;TZID=America/Toronto:20221018T120000
DTEND;TZID=America/Toronto:20221018T130000
DTSTAMP:20260405T145936
CREATED:20220627T132215Z
LAST-MODIFIED:20221011T130800Z
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SUMMARY:Global Speaker Series: Jacob Hanna\, MD\, PhD -Weizmann Institute of Science
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. Medicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Jacob Hanna\, MD\, PhD\, Senior Scientist and Professor\, Department of Molecular Genetics\, Weizmann Institute of Science. The title of this talk will be\, “Synthetic Ex Utero Embryogenesis: from Naive Pluripotent Stem Cells to Advanced Whole Embryos”. \nIn Person – Register Here \nVirtual – Register Here\nHybrid event\, with in-person and virtual options\n\nIn-person will be held at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room.\nVirtual event links will be sent after registration.\n\nMORE ABOUT JACOB HANNA: \nBorn in Rama\, an Arab Palestinian village in the Galilee region of Israel\, Professor Jacob (Yaqub) Hanna earned his BSc in medical science\, PhD in immunology\, and MD in clinical medicine summa cum laude from the Hebrew University of Jerusalem. He conducted postdoctoral research at the Whitehead Institute for Biomedical Research at MIT. He joined the department of Molecular Genetics at the Weizmann Institute in 2011. \nProfessor Hanna is pioneering techniques in induced naïve pluripotency from adult cell and synthetic whole embryo models made solely from stem cells ex utero. Professor Hanna was the lead researcher in a study that showed how further-modified iPS cells could be used to treat sickle-cell anemia in mice\, the first proof of concept of the therapeutic application of iPS cells. \nDuring his postdoctoral work\, Professor Hanna received a prestigious Novartis Fellowship from the Helen Hay Whitney Foundation. In 2010\, he was awarded the Sir Charles Clore Prize for Outstanding Appointment in the Weizmann Institute. He received an EMBO Young Investigator Award (2012)\, a Rappaport Prize in biomedical research (2013)\, a Krill Prize by the Wolf Foundation (2013)\, and the Helen and Martin Kimmel Award for Innovative Investigation (2014). In 2014\, he was featured among “40 under 40” innovative scientists by the prestigious journal Cell and was elected as a member of EMBO in 2018. In 2021\, he ranked at the top of the list of 50 leading world thinkers by Prospect magazine. \n Learn more about Jacob (Yaqub) Hanna
URL:https://mbd.ccrm.ca/event/global-speaker-series-jacob-hanna-phd-weizmann-institute-of-science/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220920T120000
DTEND;TZID=America/Toronto:20220920T130000
DTSTAMP:20260405T145936
CREATED:20220627T132505Z
LAST-MODIFIED:20220815T210942Z
UID:17495-1663675200-1663678800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Gordon Fishell\, PhD – Harvard University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. Medicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Gordon Fishell\, PhD\, Professor of Neurobiology\, Harvard Medical School and the Stanley Center at the Broad. The title of this talk will be\, “The intimate dependence and remarkable precision of cortical interneurons.” In Person – Register Here \nVirtual – Register Here\nHybrid event\, with in-person and virtual options\n\nIn-person will be held at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room.\nVirtual event links will be sent after registration.\n\nMore About gordon fishell:\nProfessor Fishell teaches in the department of Neurobiology at Harvard Medical center and is an institute member of the Broad institute. He was previously the associate director of the New York University (NYU) Neuroscience Institute\, Julius Raines Professor of Neuroscience and Physiology at NYU\, and director of the graduate program in neuroscience and physiology at the NYU School of Medicine. Professor Fishell completed his Ph.D. in neurobiology from the University of Toronto and conducted postdoctoral research at Columbia University and the Rockefeller University. His laboratory is interested in how the architecture of brain circuits are assembled\, with a special focus on the diverse populations of inhibitory interneurons that are found in both pallial and subpallial telencephalon. Professor Fishell’s laboratory has spent the past 20 years working to understand the inhibitory cells that regulate excitatory signaling in the brain. \n Learn more about Gordon Fishell
URL:https://mbd.ccrm.ca/event/global-speaker-series-gordon-fishell-phd-harvard-university/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220621T120000
DTEND;TZID=America/Toronto:20220621T130000
DTSTAMP:20260405T145936
CREATED:20220517T170108Z
LAST-MODIFIED:20220615T211439Z
UID:17239-1655812800-1655816400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Gilbert Bernier\, PhD - Université de Montréal
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Gilbert Bernier\, PhD\, Associate Professor in the Department of Neuroscience at Université de Montréal. \nThe title of this talk will be\, “Cone photoreceptor sheet transplantation for the treatment of macular degenerations” \nRegister now \nHybrid event\, with in-person and virtual options\n\nIn-person will be held at the Terrence Donnelly Centre for Cellular & Biomolecular Research\, Red Room.\nVirtual event links will be sent after registration.\n\n \nMore About Gilbert bernier:\nProfessor Gilbert Bernier performed is graduated studies in Molecular Biology at Montreal University where he characterized the gene mutated in the mouse neurological disorder dystonia musculorum. In 1997\, he moved to the Max-Planck Institute of Biophysical Chemistry in Germany to study developmental biology of the retina. Since 2001\, he is heading the laboratory of stem cell and developmental biology at Maisonneuve-Rosemont Hospital to exploit the potential of human pluripotent stem cells for the study and treatment of neurodegenerative diseases such as retinal degenerative diseases and Alzheimer’s disease. Professor Bernier has also contributed to the characterization of Polycomb group proteins function in brain cancer\, DNA repair\, and premature ageing. He is Professor at the Neuroscience Department of Montreal University since 2012. He is co-founder and CEO of StemAxonTM\, a Canadian corporation involved in the development of new treatments for neurodegenerative diseases. \n Learn more about Gilbert Bernier
URL:https://mbd.ccrm.ca/event/global-speaker-series-gilbert-bernier-phd-universite-de-montreal/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220517T120000
DTEND;TZID=America/Toronto:20220517T130000
DTSTAMP:20260405T145936
CREATED:20220412T163857Z
LAST-MODIFIED:20220516T134308Z
UID:16939-1652788800-1652792400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Klavs Jensen\, PhD - Massachusetts Institute of Technology
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Klavs Jensen\, PhD\, Warren K. Lewis Professor\, Chemical Engineering\, and Professor\, Materials Science and Engineering\, Massachusetts Institute of Technology. \nThe title of this talk will be\, “Accelerating chemical development with automation and machine learning.” \n Register for this virtual event. \n \nMore About Klavs jensen:\nKlavs F. Jensen is Warren K. Lewis Professor in Chemical Engineering and Materials Science and Engineering at the Massachusetts Institute of Technology. From 2007- July 2015 he was the Head of the Department of Chemical Engineering. His research interests include on-demand multistep synthesis\, methods for automated synthesis\, and machine learning techniques for chemical synthesis and interpreting large chemical data sets. He is a co-director of MIT’s consortium\, Machine Learning for Pharmaceutical Discovery and Synthesis\, which aims to bring machine learning technology into pharmaceutical discovery and development. Professor Jensen is a member of the US National Academy of Sciences\, the US National Academy of Engineering as well as the American Academy of Arts and Science. He is a Fellow of the American Association for the Advancement of Science (AAAS)\, and the American Institute of Chemical Engineers\, and the Royal Society of Chemistry. \n Learn more about Klavs Jensen’s lab
URL:https://mbd.ccrm.ca/event/global-speaker-series-klavs-jensen-phd-massachusetts-institute-of-technology/
LOCATION:Ontario
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220412T120000
DTEND;TZID=America/Toronto:20220412T130000
DTSTAMP:20260405T145936
CREATED:20220315T134520Z
LAST-MODIFIED:20220327T004408Z
UID:16729-1649764800-1649768400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Elmar Jaeckel\, MD - University Health Network
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Elmar Jaeckel\, MD\, Medical Director at the Liver Transplant Program\, Ajmera Transplant Centre at the University Health Network. \nThe title of this talk will be\, Tissue-specific tolerance by genetically modified regulatory T cells enables endogenous regeneration. \n Register for this virtual event. \nMore About elmar jaeckel:\nDr. Elmar Jaeckel is a trained gastroenterologist/hepatologist as well as endocrinologist/diabetologist and transplantation specialist. He is Medical Director of the Liver Transplant Program at the Transplant Centre\, University Health Network. Dr. Jaeckel studied medicine at University of Hamburg\, Yale University New Haven\, University of California San Diego\, University of Edinburgh and University of Sydney. He completed his medical training at the Hannover Medical School (MHH). He studied medical economics at the University of applied sciences in Hannover and received a bachelor as Medical Hospital Manager. Dr. Jaeckel spent a four years postdoctoral research fellowship with Harald von Boehmer at the Harvard Medical School/Joslin Diabetes Center\, Boston working on central and peripheral tolerance mechanisms in type 1 diabetes. Since 2003\, he has been leading the research group on immune tolerance and metabolic inflammation at the MHH. The group is focusing to establish tissue-specific tolerance in autoimmunity\, transplantation and metabolic inflammation. Since 2008 he is attending for gastroenterology\, hepatology\, endocrinology and diabetology at Hannover Medical School. \nDr. Jaeckel’s working group Immune Tolerance aims in establishing immune tolerance in type 1 diabetes and after biological beta cell replacement. For this purpose\, he is developing new cell and gene therapy approaches. He is involved in pursuing islet xenotransplantation in Germany and to facilitate tolerance to stem cell derived beta cells. One major research focus is the change of specificity of regulatory T cells for beta cells by the use of chimeric antigen-receptors (CARs). In addition\, he aims in local control of immune responses in metabolic inflammation in NASH patients. \nHe was co-chairing the collaborative research center transplantation for 12 years (CRC738)\, the CRC on xenotransplantation (CRC TR127) funded by the German Research Foundation and the Integrated Research Center Transplantation (IFB-Tx) funded by Federal Ministry for research and education. Besides this he received funding from the German Research Foundation\, Ministry of Health\, European Community\, Helmsley Foundation\, Juvenile Diabetes Research Foundation. \nDr. Jaeckel published numerous articles on viral hepatitis\, autoimmune liver disease\, autoimmune diabetes and islet transplantation tolerance. He developed tissue-specific regulatory T cell therapies for local tolerance induction\, which are currently being tested in clinical trials. He has numerous patents on tolerance inducing therapies and is co-founder of Quell Therapeutics aiming to develop clinical therapies for tolerance induction with regulatory T cells.
URL:https://mbd.ccrm.ca/event/global-speaker-series-elmar-jaeckel-phd-university-health-network/
LOCATION:Ontario
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220315T120000
DTEND;TZID=America/Toronto:20220315T130000
DTSTAMP:20260405T145936
CREATED:20220208T154825Z
LAST-MODIFIED:20220308T200651Z
UID:16479-1647345600-1647349200@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Anne Brunet\, PhD - Stanford University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Anne Brunet\, PhD\, Professor of Genetics at Stanford University. \nThe title of this talk will be\, Mechanisms of Aging. \n Register for this virtual event. \n \nMore About anne brunet:\nDr. Brunet obtained her B.Sc. from the Ecole Normale Supérieure in Paris and her Ph.D. from the University of Nice\, France. She did her postdoctoral training with Dr. Michael Greenberg at Harvard Medical School. Dr. Brunet is interested in the molecular mechanisms of aging and longevity. She wants to understand the mechanism of neural stem cell aging. She also seeks to discover novel genes regulating longevity\, notably developing a new short-lived vertebrate\, the African killifish. Dr. Brunet has published over 80 peer-reviewed papers and reviews. She has received several awards\, including the Pfizer/AFAR Innovation in Aging Research Award and the Vincent Cristofalo “Rising Star” Award in Aging Research. She received a Pioneer Award and a Transformative Award from the NIH Director’s fund\, which supports scientists who propose pioneering and transforming approaches to major challenges in biomedical research. \n Learn more about Anne Brunet’s lab
URL:https://mbd.ccrm.ca/event/global-speaker-series-anne-brunet-phd-stanford-university/
LOCATION:Ontario
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220215T120000
DTEND;TZID=America/Toronto:20220215T130000
DTSTAMP:20260405T145936
CREATED:20220114T175715Z
LAST-MODIFIED:20220519T003652Z
UID:16256-1644926400-1644930000@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Lior Zangi\, PhD - Icahn School of Medicine
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Lior Zangi\, PhD\, Associate Professor\, Cardiovascular Research Institute\, Genetics at Icahn School of Medicine. \nThe title of this talk will be\, mRNA-Based Approach for Treating Ischemic Heart Disease. \n Register for this virtual event. \n \nMore About Lior Zangi:\nLior Zangi\, PhD\, is an Associate Professor with Tenure at the Icahn School of Medicine at Mount Sinai\, New York. He completed his education and training at the Weizmann Institute of Science\, and Harvard University. He has established a new method\, mRNA based\, for gene delivery into skeletal and cardiac muscle. In the last year\, these mRNA delivery methods have been used for COVID19 vaccinations and promoting cardiovascular regeneration in ischemic heart disease. Currently\, Prof. Zangi’s laboratory investigates mRNA delivery method into healthy or unhealthy specific cell types and organs\, top fight different diseases such as heart failure and cancer. \n Learn more about Lior Zangi’s lab
URL:https://mbd.ccrm.ca/event/global-speaker-series-lior-zangi-phd-icahn-school-of-medicine/
LOCATION:Ontario
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20220118T120000
DTEND;TZID=America/Toronto:20220118T130000
DTSTAMP:20260405T145936
CREATED:20211214T213150Z
LAST-MODIFIED:20220117T214918Z
UID:16071-1642507200-1642510800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Trey Ideker\, PhD - University of California San Diego
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Trey Ideker\, PhD\, Professor in the Departments of Medicine\, Bioengineering and Computer Science at UC San Diego. \nThe title of this talk will be\, Building the Mind of Cancer. \n Register for this virtual event. \n \nMore About trey ideker:\nTrey Ideker\, Ph.D. is a Professor in the Departments of Medicine\, Bioengineering and Computer Science at UC San Diego. Additionally\, he is the Director or Co-Director of the National Resource for Network Biology (NRNB)\, the Cancer Cell Map Initiative (CCMI)\, the Psychiatric Cell Map Initiative (PCMI)\, and the UCSD Bioinformatics PhD Program\, and former Chief of Genetics in the Department of Medicine. Dr. Ideker received Bachelor’s and Master’s degrees from MIT in Electrical Engineering and Computer Science and his Ph.D. from the University of Washington in Molecular Biology under the supervision of Dr. Leroy Hood. He currently serves on the Editorial Boards for Cell\, Cell Reports\, Molecular Systems Biology\, and PLoS Computational Biology and is a Fellow of AAAS and AIMBE. He is a member of the Web of Science Highly Cited Researchers list\, reserved each year for the top 1% of scientists by citations. He was named a Top 10 Innovator by Technology Review and was the recipient of the Overton Prize from the International Society for Computational Biology. His work has been featured in news outlets such as NPR\, BBC\, New York Times\, Scientific American\, Smithsonian\, Discover\, Forbes magazine\, Popular Mechanics and People Magazine. \nThe Ideker Laboratory seeks to map the molecular networks governing cancer and neurological disorders and to use these maps in artificially intelligent systems for precision medicine. The laboratory also produces the Cytoscape ecosystem of network analysis tools\, which has been cited over 25\,000 times. \n Learn more about Trey Ideker’s lab
URL:https://mbd.ccrm.ca/event/global-speaker-series-trey-ideker-phd-university-of-california-san-diego/
LOCATION:Ontario
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20211116T120000
DTEND;TZID=America/Toronto:20211116T130000
DTSTAMP:20260405T145936
CREATED:20210729T141929Z
LAST-MODIFIED:20211108T163620Z
UID:14767-1637064000-1637067600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Elly Tanaka\, PhD - Research Institute of Molecular Pathology (IMP)
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Elly Tanaka\, PhD\, senior scientist at the Research Institute of Molecular Pathology (IMP) in Vienna\, Austria. \nThe title of this talk will be\, Deciphering the cellular and molecular basis of limb regeneration ability and inability. \n Register for this virtual event. \n \nMore About ELLY TANAKA:\nElly Tanaka is currently a senior scientist at the Research Institute of Molecular Pathology (IMP) in Vienna\, Austria. \nProfessor Tanaka studies the molecular cell biology of limb and spinal cord regeneration as well as the evolution of regeneration. She received her PhD from University of California in San Francisco where she worked with Marc Kirschner in the Department of Biochemistry. She did her post-doctoral research on limb regeneration with Jeremy Brockes at the Ludwig Institute and University College London. \nIn 1999 she moved to the Max-Planck Institute of Molecular Cell Biology and Genetics in Dresden where she started a junior research group working on axolotl spinal cord regeneration. In 2004 she was promoted to associate level. In 2008 she became Chair of the Animal Models of Regeneration in the Center for Regenerative Therapies\, Dresden at the Technische Universität Dresden where she holds an honorary professorship. In 2016 she moved to the Institute of Molecular Pathology as a senior scientist. She has received a number of awards including the Schering Prize\, the Schroedinger Prize and the FEBS EMBO Women in Science Award. \n Learn more about Elly Tanaka’s lab
URL:https://mbd.ccrm.ca/event/global-speaker-series-elly-tanaka-phd/
LOCATION:Ontario
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20211019T120000
DTEND;TZID=America/Toronto:20211019T130000
DTSTAMP:20260405T145936
CREATED:20210729T141125Z
LAST-MODIFIED:20210804T141519Z
UID:14762-1634644800-1634648400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Wilson Wong\, PhD - Boston University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Wilson Wong\, PhD\, Associate Professor in the Department of Biomedical Engineering at Boston University. \nThe title of this talk will be\, Mammalian Cell Design Using Synthetic Biology \n Register for this virtual event. \n \nMore About WILSON WONG:\nWilson Wong is an Associate Professor in the Biomedical Engineering Department at Boston University\, and a core member of the BU Biological Design Center. His lab is focused on developing synthetic biology tools in mammalian systems for cell-based immunotherapy. He received his B.S. degree in Chemical Engineering from UC Berkeley and a Ph.D. degree in Chemical Engineering from UCLA under the guidance from Dr. James Liao. He did his postdoctoral work with Dr. Wendell Lim and Arthur Weiss at UCSF. He is the recipient of the NIH Director’s New Innovator and NSF CAREER Award. \n Learn more about Wilson Wong’s lab
URL:https://mbd.ccrm.ca/event/global-speaker-series-wilson-wong-phd-boston-university/
LOCATION:Ontario
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20210921T120000
DTEND;TZID=America/Toronto:20210921T130000
DTSTAMP:20260405T145936
CREATED:20210728T195206Z
LAST-MODIFIED:20210831T134648Z
UID:14756-1632225600-1632229200@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Dale Greiner\, PhD - University of Massachusetts Medical School
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Dale Greiner\, PhD\, Professor of Molecular Medicine and Co-Director of the Diabetes Center of Excellence at University of Massachusetts Medical School. \nThe title of this talk will be\, TBC \n Register for this virtual event. \n \nMore About DALE GREINER:\nDr. Greiner is nationally and internationally recognized for pioneering the development and use of mice engrafted with functional human cells and tissues. This work has generated high interest in the biomedical research community for use as a preclinical model for the investigation of human diabetes\, cancer\, infectious disease\, regenerative medicine and autoimmunity. The unique animal model allows Dr. Greiner and his team to investigate autoimmune type 1 diabetes and the cells that regulate immune responses in humans. \nHe currently serves as Vice Chair of the Institutional Animal Care and Use Committee and member of the Diabetes Research Center Executive Committee and the Flow Cytometry Advisory Committee. Over the past four decades\, he has co-authored more than 300 publications in the research specialization areas of Immunology\, Transplantation\, Autoimmunity\, and Diabetes. \nDr. Greiner has served as a regular member of the National Institutes of Health Immunology Sciences Study Section and the Hypersensitivity\, Autoimmune\, and Immune-mediated Diseases Study Section. He has also served as Chair of the Veterans Administration Immunology Review Subcommittee B and Chair of many ad hoc NIH and JDRF study sections. In addition\, he has served as Chair of the Medical Science Review Committee for the Juvenile Diabetes Research Foundation\, Chairman of the American Diabetes Association Scientific Sessions Committee\, as well as Program Chair and Council Chair of the American Diabetes Association Council on Immunology\, Immunogenetics and Transplantation. \nThe recipient of numerous awards for his research\, Dr. Greiner has received the A.J. Julian Scholarship for Academic Excellence\, the Basil O’Connor Scholar Research Award from the March of Dimes\, and the Kayla and Gerald Grodsky and the David Rumbough Awards from the Juvenile Diabetes Research Foundation\, Int. \n Learn more about Dale Greiner’s lab
URL:https://mbd.ccrm.ca/event/global-speaker-series-dale-greiner-phd-university-of-massachusetts-medical-school/
LOCATION:Ontario
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20210622T120000
DTEND;TZID=America/Toronto:20210622T130000
DTSTAMP:20260405T145936
CREATED:20210527T191759Z
LAST-MODIFIED:20210601T190458Z
UID:13747-1624363200-1624366800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Juan Melero-Martin\, PhD - Harvard Medical School
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Juan Melero-Martin\, PhD\, Associate Professor of Surgery\, Boston Children’s Hospital\, Harvard Medical School. \nThe title of this talk will be\, “Bioengineering drug-secreting vascular networks from pluripotent stem cells” \n Register for this virtual event. \n \nMore About Juan Melero-Martin:\nProfessor Melero-Martin graduated in Chemical Engineering from the University of Seville\, Spain\, in 1998. After working three years in industry\, he went on to earn a PhD in Biochemical Engineering from the University of Birmingham\, UK\, in 2005. He then trained as a post-doctoral fellow in the Vascular Biology Program at Boston Children’s Hospital. He joined the Department of Cardiac Surgery at Boston Children’s Hospital in 2008. Currently\, he is an Associate Professor of Surgery\, Harvard Medical School\, and the inaugural incumbent of an endowed Chair in Cardiac Surgery at Boston Children’s Hospital. \nProfessor Melero-Martin’s research is focused on how to build vascular networks and vascularize tissues. His laboratory is a reference in human blood-derived circulating endothelial colony-forming cells (ECFCs) and has contributed multiple original papers on various aspects of ECFC biology. His group has developed novel approaches to bioengineer vascular networks and has shown that bioengineered vascular networks can be generally used to harness the regenerative potential of other stem cells. In addition\, his group developed a model that uses genetically engineered blood vessels to achieve the controlled release of therapeutic proteins in vivo. \n Learn more about Juan Melero-Martin’s lab
URL:https://mbd.ccrm.ca/event/global-speaker-series-juan-melero-martin-phd-harvard-medical-school/
LOCATION:Ontario
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20210518T120000
DTEND;TZID=America/Toronto:20210518T130000
DTSTAMP:20260405T145936
CREATED:20210316T173415Z
LAST-MODIFIED:20210728T154522Z
UID:13217-1621339200-1621342800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Jeffrey Millman\, PhD - Washington University in St. Louis
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Jeffrey Millman\, PhD\, Assistant Professor of Medicine and Biomedical Engineering\, Washington University in St. Louis. \nThe title of this talk will be\, “Engineering Human Islets From Stem Cells For Diabetes Cellular Therapy” \n Register for this virtual event. \n \nMore About Jeffrey Millman:\nProfessor Jeffrey Millman received his bachelor’s degree from North Carolina State University and PhD in Chemical Engineering from MIT. He completed his post-doctoral training in the laboratory of Dr. Douglas Melton at Harvard University. He was recruited by the Division of Endocrinology\, Metabolism and Lipid Research in the Department of Medicine at the Washington University School of Medicine as an Assistant Professor in 2015 and is an affiliated faculty in the Department of Biomedical Engineering. \nHis current research is focused on synergizing both biomedical engineering and cell biology approaches to use stem cells for the study and treatment of diabetes. He is developing new approaches for the differentiation of insulin-producing islets from stem cells and improving their utility for cell replacement therapy and in vitro disease models. His innovations have been licensed to several biotechnology and startup companies in the diabetes space. His laboratory is supported by the NIH NIDDK and JDRF. \nProfessor Millman received an American Institute of Chemical Engineering 35 Under 35 Award in 2017\, Chemical and Biomolecular Engineering Distinguish Young Alumni Award from North Carolina State University in 2019\, and was named a Cellular and Molecular Bioengineering (CMBE) Rising Star by Biomedical Engineering Society in 2021. \n Learn more about Jeffrey Millman’s lab
URL:https://mbd.ccrm.ca/event/global-speaker-series-jeffrey-millman-phd-washington-university-in-st-louis/
LOCATION:Ontario
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20210414T120000
DTEND;TZID=America/Toronto:20210414T130000
DTSTAMP:20260405T145936
CREATED:20210323T181821Z
LAST-MODIFIED:20210409T164438Z
UID:13297-1618401600-1618405200@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Sonja Schrepfer\, PhD\, University of California San Francisco (UCSF)
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Sonja Schrepfer\, PhD\, Professor\, University of California San Francisco (UCSF)\, and Scientific Founder and SVP\, Sana Biotechnology Inc. \nThe title of this talk will be\, “Identifying and overcoming the immunological hurdle in stem cell therapy for regenerative medicine” \n Register for this virtual event. \n \nMore About Sonja Schrepfer:\nDr. Schrepfer’s research career has been dedicated to making fundamental discovers in transplant and stem cell immunobiology. Work by Dr. Schrepfer is at the forefront of stem immunobiology and paves the way for treatment of a wide range of diseases – from supporting functional recovery of failing myocardium to the derivation of other cell types to treat diabetes\, blindness\, cancer\, lung\, neurodegenerative\, and related diseases. She spent many years examining in detail the fetomaternal interface for application to the envisioned cell therapy. Her work with one of the most antigenic phenotypes\, antigen-presenting endothelial cells\, demonstrates that hypo-immunogenic cells reliably evade immune rejection in allogeneic recipients that are entirely mismatched in their major histocompatibility complex profile\, and further\, these cells show long-term survival without immunosuppression in mice and humanized mice (published in Nature Biotechnology in 2019 and JEM in 2021). These findings – truly hypo-immunogeneic iPSCs – achieve the “holy grail” of stem cell immunobiology. \nDr. Schrepfer\, Professor at the University of California San Francisco (UCSF)\, and Scientific Founder and SVP from Sana Biotechnology Inc.\, was trained as cardiac surgeon in the Cardiothoracic Surgery Departments in Munich and Hamburg\, Germany before pursuing a career as a full-time scientist. She received her PhD in transplant immunology and joined Stanford University to start her own research group in 2007 in the Department of Cardiothoracic Surgery. Dr. Schrepfer’s findings have been highlighted in leading journals such as Nature and Science and she received numerous awards\, such as the prestigious DFG-Heisenberg professorship (2009)\, the Innovation Award from Academia (Germany; 2014)\, the science award from the German Academy of Sciences (Leopoldina; 2015)\, and the Galenus-von-Pergamon Medal in Basic Medical Sciences (2019). \n Learn more about Sonja Schrepfer’s lab
URL:https://mbd.ccrm.ca/event/global-speaker-series-sonja-schrepfer-phd-professor-university-of-california-san-francisco-ucsf/
LOCATION:Ontario
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20210316T120000
DTEND;TZID=America/Toronto:20210316T130000
DTSTAMP:20260405T145936
CREATED:20210211T171832Z
LAST-MODIFIED:20210216T201224Z
UID:12647-1615896000-1615899600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Magdalena Götz\, PhD - University of Munich and Helmholtz Center Munich
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Magdalena Götz\, PhD\, professor at the Biomedical Center\, University of Munich and Institute for Stem Cell Research\, Helmholtz Center Munich\, Germany. \nThe title of this talk will be\, “Novel mechanisms of neurogenesis and neural repair” \n Register for this virtual event. \n \nMore About Magdalena Götz: \nProfessor Götz’s lab studies the mechanisms of neurogenesis in order to implement them for neuronal repair. She will present recent work on a novel centrosomal protein\, Akna\, regulated with great precision in subsets of neural stem cells. This led Professor Götz’s lab to unravel an unprecedented centrosome heterogeneity in human neural stem cells revealing and verifying novel disease candidates. She will proceed to present recent data on a master regulator of nuclear compartmentalization by liquid phase transition with key roles in promoting neural stem cell self-renewal and neurogenesis. Trnp1 is also critical for direct neuronal reprogramming which leads to discuss recent progress in direct neuronal reprogramming as a means to replace lost neurons after brain injury. The presentation will be concluded by discussing the integration of replaced neurons into the circuitry of the murine cerebral cortex and present unpublished data about the mechanisms regulating this integration. Taken together\, our knowledge about basic mechanisms of neurogenesis allowed making great strides towards neuronal repair. \n Learn more about Magdalena Götz’s lab
URL:https://mbd.ccrm.ca/event/global-speaker-series-magdalena-gotz-phd-university-of-munich-and-helmholtz-center-munich/
LOCATION:Virtual
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20210216T120000
DTEND;TZID=America/Toronto:20210216T130000
DTSTAMP:20260405T145936
CREATED:20201222T071349Z
LAST-MODIFIED:20210202T165247Z
UID:11577-1613476800-1613480400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Manu Platt\, PhD - Georgia Institute of Technology\, and Emory University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Manu Platt\, PhD\, associate professor at the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology\, and Emory University. \nThe title of this talk will be\, “Things Fall Apart: Proteolytic Networks in Tissue Destructive Diseases” \n Register for this virtual event \n \nMore About Manu Platt:\nManu Platt received his BS in biology from Morehouse College in 2001 and his PhD from the Georgia Tech and Emory joint program in biomedical engineering in 2006. He finished his post–doctoral training at MIT in orthopedic tissue engineering and systems biology prior to returning to Georgia Tech and Emory’s Joint Department of Biomedical Engineering in 2009\, where he has since been promoted and tenured. His research centres on proteolytic mechanisms of tissue remodeling during disease progression using both experimental and computational approaches. \nIntegrated with his research program is his mentoring goal of changing the look of the next generation of scientists and engineers to include all colours\, genders\, and backgrounds. Aligned with that goal\, Dr. Platt\, along with Bob Nerem\, co-founded and co-directs Project ENGAGES (Engaging the Next Generation At Georgia Tech in Engineering and Science)\, a program paying African-American high school students from Atlanta Public Schools to be researchers in Georgia Tech labs since 2013.
URL:https://mbd.ccrm.ca/event/global-speaker-series-manu-platt-phd-georgia-institute-of-technology-and-emory-university/
LOCATION:Ontario
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20210119T120000
DTEND;TZID=America/Toronto:20210119T130000
DTSTAMP:20260405T145936
CREATED:20201221T222251Z
LAST-MODIFIED:20210113T203542Z
UID:11573-1611057600-1611061200@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Allon Klein\, PhD - Harvard University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Allon Klein\, PhD\, an Associate Professor of Systems Biology at Harvard Medical School. \nThe title of this talk will be\, “Lineage tracing on transcriptional landscapes” \n Register for this virtual event. \n  \n \nMore About Allon Klein: \nProfessor Klein is an Associate Professor of Systems Biology at Harvard Medical School. He obtained his PhD in physics with Prof. Ben Simons (Cambridge University)\, and a postdoc in experimental systems biology with Prof. Marc Kirschner (Harvard Medical School). Dr. Klein studies how cells make fate choices in developing and adult tissues. He pioneered droplet microfluidics for single-cell RNA-Seq\, computational methods for analyzing single-cell genomics data\, and methods for quantitative clonal analysis. He focuses on the early embryo\, epithelial tissues and the hematopoietic system as model systems. His work includes the discovery of a cell type in the airway epithelium (the pulmonary ionocyte)\, defining the identity of red blood cell progenitors\, and establishing the transcriptional dynamics of early vertebrate development at single cell resolution. In 2018\, Dr. Klein’s work mapping embryonic development in vertebrates was recognized by the AAAS “Breakthrough of the Year\,” and in 2020 he received the Dr. Susan Lim Award for Outstanding Young Investigator from the International Society for Stem Cell Research (ISSCR). \n Learn more about Allon Klein’s lab
URL:https://mbd.ccrm.ca/event/global-speaker-series-allon-klein-phd-harvard-medical-school/
LOCATION:Virtual
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20201117T120000
DTEND;TZID=America/Toronto:20201117T130000
DTSTAMP:20260405T145936
CREATED:20200204T180647Z
LAST-MODIFIED:20201103T223731Z
UID:7803-1605614400-1605618000@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Fei Chen\, PhD - Broad Institute of MIT and Harvard
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Fei Chen\, PhD\, a Schmidt Fellow at the Broad Institute of Harvard University and the Massachusetts Institute of Technology. \nThe title of this talk will be\, “Next generation tools for spatial and temporal genomics” \nClick HERE to register for this virtual event. \n  \n \nMore About Fei Chen: \nFei Chen is currently a core faculty member at the Broad Institute of MIT and Harvard\, and assistant professor at Harvard Stem Cell and Regenerative Biology. He obtained his PhD in biological engineering from the Massachusetts Institute of Technology in 2016. Fei was a Schmidt Fellow at the Broad Institute of MIT and Harvard from 2017-2020. Fei was an Axline scholar at the California Institute of Technology and graduated with a bachelor’s degree in Electrical Engineering in 2011. At the Broad Institute of MIT and Harvard\, his lab sets out pioneer novel tools at the intersection of genomics and microscopy to bridge single-cell genomics with space and time to enable discoveries of where cell types are localized within intact tissues\, when relevant transcriptional modules are active. His awards include the National Institutes of Health Director’s Early Independence Award and the Allen Distinguished Investigator Award.
URL:https://mbd.ccrm.ca/event/global-speaker-series-fei-chen-phd-broad-institute/
LOCATION:Virtual
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20201020T120000
DTEND;TZID=America/Toronto:20201020T130000
DTSTAMP:20260405T145936
CREATED:20191127T181319Z
LAST-MODIFIED:20200918T210631Z
UID:7553-1603195200-1603198800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Bryan Dickinson\, PhD - University of Chicago
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Bryan Dickinson\, PhD\, associate professor of chemistry at the University of Chicago. \nThe title of this talk will be\, “Synthetic biology approaches to study and exploit RNA regulation” \nClick HERE to register for this virtual event. \n \nMore About Bryan Dickinson: \nBryan Dickinson earned his BS in biochemistry from the University of Maryland\, College Park and his PhD in chemistry from the University of California at Berkeley for work performed with Professor Christopher Chang. His graduate work focused on the synthesis and application of small molecule fluorescent probes for the detection of hydrogen peroxide in living systems. Then\, as a Jane Coffin Childs Memorial post-doctoral fellow with Professor David Liu at Harvard University\, he developed new methods to rapidly evolve proteins to perform novel functions. Bryan joined the faculty at the University of Chicago in the Department of Chemistry in the summer of 2014 and is a member of the University of Chicago Comprehensive Cancer Center. He was promoted to Associate Professor in 2019.
URL:https://mbd.ccrm.ca/event/global-speaker-series-bryan-dickinson-october-2020/
LOCATION:Virtual
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20200915T120000
DTEND;TZID=America/Toronto:20200915T130000
DTSTAMP:20260405T145936
CREATED:20200204T180324Z
LAST-MODIFIED:20200820T135938Z
UID:7801-1600171200-1600174800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: James J. Collins\, PhD - Massachusetts Institute of Technology (MIT)
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome James J. Collins\, PhD\, Termeer Professor of Medical Engineering & Science and Professor of Biological Engineering at MIT\, as well as a Member of the Harvard-MIT Health Sciences & Technology Faculty. \nThe title of this talk will be\, “Harnessing synthetic biology and AI to address the COVID-19 pandemic” \nClick HERE to register for this Virtual Event. \n  \n \nMore About Professor James J. Collins: \nProfessor Collins is also a Core Founding Faculty member of the Wyss Institute for Biologically Inspired Engineering at Harvard University\, an Institute Member of the Broad Institute of MIT and Harvard and a member of the Medicine by Design’s Scientific Advisory Board. He is one of the founders of the field of synthetic biology\, and his research group is currently focused on using synthetic biology to create next-generation diagnostics and therapeutics. Professor Collins’ patented technologies have been licensed by over 25 biotech\, pharma and medical devices companies\, and he has helped to launch a number of companies\, including Synlogic and Sherlock Biosciences. He has received numerous awards and honors\, including a Rhodes Scholarship and a MacArthur “Genius” Award\, and he is an elected member of all three national academies – the National Academy of Sciences\, the National Academy of Engineering\, and the National Academy of Medicine.
URL:https://mbd.ccrm.ca/event/global-speaker-series-september-2020/
LOCATION:Online
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20200616T120000
DTEND;TZID=America/Toronto:20200616T130000
DTSTAMP:20260405T145936
CREATED:20191127T180959Z
LAST-MODIFIED:20201203T220705Z
UID:7551-1592308800-1592312400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Ulrich Steidl\, MD\, PhD - Albert Einstein College of Medicine
DESCRIPTION:Medicine by Design\, in partnership with the McEwen Stem Cell Institute\, is pleased to welcome Ulrich Steidl\, MD\, PhD\, professor of cell biology and medicine at the Albert Einstein College of Medicine. The title of this talk will be\, “Stem cell heterogeneity and transcription state dynamics in normal and malignant hematopoiesis.” \n  \n \nAbout Ulrich Steidl\nDr. Steidl is the Diane and Arthur B. Belfer Faculty Scholar in Cancer Research\, director of the Stem Cell Isolation and Xenotransplantation Facility\, and a professor of cell biology and of medicine at Albert Einstein College of Medicine\, and associate chair for translational research in oncology at Montefiore Medical Centre. \nThe Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians.
URL:https://mbd.ccrm.ca/event/global-speaker-series-ulrich-steidl-june-2020/
LOCATION:Online
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20200218T120000
DTEND;TZID=America/Toronto:20200218T130000
DTSTAMP:20260405T145936
CREATED:20191127T175612Z
LAST-MODIFIED:20200130T202459Z
UID:7543-1582027200-1582030800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Stuart Forbes\, MB\, ChB - University of Edinburgh
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians.  \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute and the Ontario Institute for Regenerative Medicine\, is pleased to welcome Stuart Forbes\, MB\, ChB\, director of the Centre for Regenerative Medicine and professor of transplantation and regenerative medicine at the University of Edinburgh\, and consultant hepatologist at the Scottish Liver Transplant Unit. He will give a talk titled\, “Developing regenerative therapies for the damaged liver.” \n\nDownload event poster\nThe event will be livestreamed (link will be live shortly before event)\n\n  \nTalk Abstract\nThe normal liver regenerates well after injury but in severe or chronic damage the regeneration capability begins to fail and cellular senescence develops. We have studied human liver injury and regeneration to develop mouse models that develop epithelial senescence and model human disease. This has revealed plasticity between the biliary and hepatocyte population. The epithelial senescence also drives liver pathology such as fibrosis and can be targeted using small molecule approaches. \nBased upon our studies of liver injury and regeneration we have been developing cell therapies for liver disease including macrophage cell therapy for liver cirrhosis which is now in phase 2. \n  \nBiography\nStuart Forbes is Professor of Transplantation and Regenerative Medicine\, at the University of Edinburgh and the Scottish Liver Transplant Unit. His research focuses on how the chronically damaged liver regenerates and how these mechanisms process becomes deranged in liver and bile duct cancer. Prof. Forbes is Director of the MRC Centre for Regenerative Medicine\, University of Edinburgh which houses 230+ scientists and clinicians. He is Director of the UK wide UKRMP Hub for engineering and exploiting the stem cell niche which aims to exploit the biology of stem cell niches for translational benefit. Prof. Forbes is a consultant Hepatologist at the Scottish Liver Transplant Unit\, Royal Infirmary of Edinburgh and has clinical interests in liver failure\, cancer and transplantation and is running phase 1 and 2 trials of macrophage cell therapy for liver cirrhosis.
URL:https://mbd.ccrm.ca/event/global-speaker-series-stuart-forbes-february-2020/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20200121T120000
DTEND;TZID=America/Toronto:20200121T130000
DTSTAMP:20260405T145936
CREATED:20191127T174717Z
LAST-MODIFIED:20200110T222642Z
UID:7536-1579608000-1579611600@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Naomi Leonard\, PhD - Princeton University
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the McEwen Stem Cell Institute and the Ontario Institute for Regenerative Medicine\, is pleased to welcome Naomi Leonard\, PhD\, Edwin S. Wilsey Professor in the Department of Mechanical and Aerospace Engineering at Princeton University. She will deliver a talk titled “Resilience and the Dynamics of Spreading Processes“. \n\nDownload poster\nLivestream talk (NOTE: Medicine by Design’s YouTube channel will go live just before the talk begins)\n\n  \nTalk Abstract\nSpreading processes impact biological\, social\, and technological systems. To systematically derive testable predictions and the means to manage spreading\, models are needed that predict spreading dynamics in terms of a few parameters. We study a spreading model in which interacting agents can adjust their susceptibility to the spreading process after first exposure. The model is motivated by an investigation of regulation of foraging by desert harvester ants. Using an analytically tractable model that predicts behaviors exhibited in field data\, we show how resilience of colony foraging rates to changing temperature and humidity can be explained by ants modifying their susceptibility to the spread of foraging\, once exposed to outside conditions. To generalize these results\, we propose and analyze a network contagion model with adjustable susceptibility and agent heterogeneity. We show how four dynamic regimes are distinguished by four numbers that depend on network structure and heterogeneity. In the bi-stable regime\, not captured in traditional models\, there can be a rapid cascade after a long period of quiescence. We show further how our results allow for systematic design of control strategies to suppress or promote spreading. \nThis is joint work with Renato Pagliara and (for the ant foraging study) Deborah Gordon. \nBiography\nNaomi Ehrich Leonard is Edwin S. Wilsey Professor of Mechanical and Aerospace Engineering and associated faculty in Applied and Computational Mathematics at Princeton University.  She is affiliated with the Program in Quantitative and Computational Biology and the Princeton Neuroscience Institute.  Naomi is a control theorist whose work involves analysis and design of feedback and interconnection in complex\, dynamical systems.  She uses mathematical models to study mechanisms of collective motion and collective decision-making for multi-agent systems in biology and in engineering.  She has applied her work to animal group at many scales as well as to rule-based improvisational dance.  She led a multidisciplinary ocean sensing project with a month-long deployment of an automated\, adaptive network of underwater robotic vehicles in Monterey Bay\, CA.  She received her BSE in Mechanical Engineering from Princeton University and her PhD in Electrical Engineering from the University of Maryland.  She is a MacArthur Fellow\, and Fellow of the American Academy of Arts and Sciences\, SIAM\, IEEE\, IFAC\, and ASME. \n\nLearn more
URL:https://mbd.ccrm.ca/event/global-speaker-series-naomi-leonard-phd-january-2020/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20191119T120000
DTEND;TZID=America/Toronto:20191119T130000
DTSTAMP:20260405T145936
CREATED:20181210T172653Z
LAST-MODIFIED:20191126T154104Z
UID:6168-1574164800-1574168400@mbd.ccrm.ca
SUMMARY:Global Speaker Series: James Wells\, PhD - Cincinnati Children's Hospital Medical Centre
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome James Wells\, PhD\, director for research\, Division of Endocrinology\, and chief scientific officer\, Center for Stem Cell and Organoid Medicine (CuSTOM) at the Cincinnati Children’s Hospital Medical Centre\, and a professor in the Department of Pediatrics at the University of Cincinnati. He will give a talk titled\, “Using human pluripotent stem cells to study development\, diabetes and digestive disease.” \n\n 	 Download event poster\n 	 This event will be livestreamed (link will be live shortly before event)\n\nBiography\nDr. Wells is an endowed professor of Pediatrics at the Cincinnati Children’s Hospital Medical Center. He is in the Division of Developmental Biology\, is the Director for Basic Research in the Division of Endocrinology and was appointed Chief Scientific Officer of the Center for Stem Cell and Organoid Medicine. \nDr. Wells’ research focuses on the processes by which gastrointestinal and endocrine organs form in the developing embryo and how they maintain systemic metabolic homeostasis postnatally. This work in developmental biology has provided the basis for the efforts to generate human cells and tissues from pluripotent stem cells. His lab pioneered approaches to generate gastrointestinal (GI) tissue organoids of the stomach\, intestine\, and colon from human pluripotent stem cells. Human organoids and mouse models are being used in the lab to study endocrine control of digestion and metabolism\, congenital defects of the digestive tract\, and enteric pathogens. In addition\, Dr. Wells and his colleagues are using organoids as a basis for tissue engineering efforts to generate functional tissues for transplantation. \n Learn more about James Wells
URL:https://mbd.ccrm.ca/event/global-speaker-series-james-wells-november-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20191022T120000
DTEND;TZID=America/Toronto:20191022T130000
DTSTAMP:20260405T145936
CREATED:20181210T172224Z
LAST-MODIFIED:20200424T173347Z
UID:6166-1571745600-1571749200@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Karen Christman\, PhD - University of California\, San Diego
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Karen Christman\, PhD\, a professor of bioengineering at the Sanford Consortium for Regenerative Medicine at the University of California\, San Diego. She will give a talk titled\, “Decellularized extracellular matrix based hydrogels for regenerative engineering.” \n Download event poster\n This event will be livestreamed (link will be live shortly before event) \nTalk Abstract\nThe extracellular matrix (ECM) is nature’s scaffold\, and in recent years\, researchers have isolated these scaffolds for tissue engineering applications by removing the cellular components\, a process called decellularization. These scaffolds are known to promote cell influx\, regeneration\, and healing in a variety of tissues\, and their degradation products have angiogenic\, chemoattractant\, and antimicrobial properties\, as well as promote cell proliferation. By removal of the cellular antigens\, these scaffolds are considered biocompatible\, and xenogeneic sources can be used. While these scaffolds retain the native ECM structure\, they are not amenable to minimally invasive\, injectable procedures.  We have developed a variety of injectable ECM derived hydrogels that self-assemble to form porous\, nanofibrous scaffolds once injected in vivo or brought to physiological conditions in vitro.  These ECM based scaffolds have been shown to increase tissue specific differentiation and maturation of a variety of progenitor and stem cells in vitro\, and are showing promise in vivo in several tissues including the myocardium and skeletal muscle.  This talk will cover the recent progress with these materials including the first clinical trial in myocardial infarction patients. \nBiography\nDr. Christman is a Professor in the Department of Bioengineering in the Jacobs School of Engineering at UC San Diego.  She received her B.S. in Biomedical Engineering from Northwestern University in 2000 and her Ph.D. from the University of California San Francisco and Berkeley Joint Bioengineering Graduate Group in 2003\, where she examined in situ approaches to myocardial tissue engineering.  She was also a NIH postdoctoral fellow at the University of California\, Los Angeles in the fields of polymer chemistry and nanotechnology.  Dr. Christman joined the Department of Bioengineering in 2007 and is a member of the Institute of Engineering in Medicine at the University of California\, San Diego.  Her lab\, which is housed in the Sanford Consortium for Regenerative Medicine\, focuses on developing novel biomaterials for tissue engineering and regenerative medicine applications\, and has a strong translational focus with the main goal of developing minimally invasive therapies for cardiovascular disease and women’s health.  Dr. Christman is a fellow of the American Heart Association and the American Institute for Medical and Biological Engineering\, and has received several awards including the NIH Director’s New Innovator and Transformative Research Awards\, the Wallace H. Coulter Foundation Early Career Translational Research Award\, the American Heart Association Western States Innovative Sciences Award\, and the Tissue Engineering and Regenerative Medicine Society’s Young Investigator and Senior Scientist Awards.  Dr. Christman is also co-founder of Ventrix\, Inc.\, which has completed a Phase I clinical trial and is currently planning a Phase II trial with the cardiac extracellular matrix hydrogel technology developed in her lab at UC San Diego. \n Learn more about Karen Christman
URL:https://mbd.ccrm.ca/event/global-speaker-series-karen-christman-october-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190917T120000
DTEND;TZID=America/Toronto:20190917T130000
DTSTAMP:20260405T145936
CREATED:20181210T171838Z
LAST-MODIFIED:20191126T154223Z
UID:6164-1568721600-1568725200@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Guo-Li Ming\, MD\, PhD - University of Pennsylvania
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Guo-Li Ming\, MD\, PhD\, professor of neuroscience at the Perelman School of Medicine\, University of Pennsylvania. She will give a talk titled\, “Brain-Region-Specific Organoids for Modeling Neurodevelopment and Disease.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\nTalk Abstract\nThree dimensional (3D) organoid cultures from human iPSCs have been recently developed to recapitulate the development and resemble the cytoarchitecture of various organs. Human brain is probably the most complex organ in the human body.  Several proof of principle studies demonstrate that human brain organoids can serve as a unique experimental model to probe the molecular and cellular mechanisms underlying the human brain development and to model neurodevelopmental disorders\, such as microcephaly and autism. We have developed various protocols to produce brain-region specific organoids derived from human iPSCs using a novel miniaturized spinning bioreactor\, including forebrain\, midbrain and hypothalamus organoids.  I will present our recent progress on using these organoids as model systems to study human neurogenesis. \nLearn more about Guo-Li Ming
URL:https://mbd.ccrm.ca/event/global-speaker-series-guo-li-ming-september-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190718T120000
DTEND;TZID=America/Toronto:20190718T130000
DTSTAMP:20260405T145936
CREATED:20190610T150117Z
LAST-MODIFIED:20191126T154434Z
UID:6713-1563451200-1563454800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Shulamit Levenberg\, PhD — Technion-Israel Institute of Technology
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Shulamit Levenberg\, PhD\, Dean of the Faculty of Biomedical Engineering at Technion-Israel Institute of Technology and the inaugural Medicine by Design Scholar in Residence. The title of her talk is “Vascularization Dynamics in Engineered Tissues.” \n\nDownload event poster\n\nBiography\nProfessor Shulamit Levenberg is the elected Dean of the Biomedical Engineering Department at the Technion. She also serves as the director of the Technion Center for 3D Bioprinting and The Rina & Avner Schneur Center for Diabetes Research. Professor Levenberg earned her PhD at the Weizmann Institute of Science\, where she focused on cell adhesion dynamics and signaling\, and pursued her post-doctoral research in tissue engineering at MIT\, in the lab of Professor Robert Langer. In 2004\, she joined the Technion Faculty of Biomedical Engineering where she conducts interdisciplinary research on stem cells and tissue engineering. She spent a sabbatical year (2011-2012) as a visiting professor at the Wyss Institute for Biology Inspired Engineering at Harvard University and a summer sabbatical (2017) at the University of Western Australia as a winner of the Raine Visiting Professor Award. Professor Levenberg received the Krill Prize for excellence in scientific research\, awarded by the Wolf Foundation\, and was named by Scientific American as a “Research Leader” in tissue engineering\, for her seminal work on vascularization of engineered tissues. She also received the France-Israel Foundation Prize\, the Italian Excellence for Israel Prize\, the Teva Research Prize and the Juludan Prize. In 2018\, she received the Rappaport Prize for Biomedical Sciences. Professor Levenberg has authored more than 100 publications\, and presented her work in over 100 international conferences as an invited or keynote speaker. She is founder and chief scientific officer of two start-up companies in the areas of cultured meat and nanoliter arrays for rapid antimicrobial susceptibility testing.  She is a member of the Israel National Counsel for Bioethics and is actively involved in training young scientists.
URL:https://mbd.ccrm.ca/event/global-speaker-series-shulamit-levenberg-july-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190618T120000
DTEND;TZID=America/Toronto:20190618T130000
DTSTAMP:20260405T145936
CREATED:20190510T164043Z
LAST-MODIFIED:20191126T154411Z
UID:6590-1560859200-1560862800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Kevin Chalut\, PhD — University of Cambridge
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Kevin Chalut\, PhD\, a Royal Society University Research Fellow\, Cavendish Laboratory\, at the University of Cambridge and principal investigator in the Cambridge Stem Cell Institute. He will give a talk titled\, “Mechanical signalling and cell fate.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\n  \nTalk Abstract\nThe role of mechanical signaling in cell fate choice has been largely overlooked; however\, it plays a significant role in tuning cellular response to signals. My lab is investigating the interplay between biochemical signaling and mechanical signaling in cell fate decisions. I will show first in the mouse embryo that biochemical signaling modulates cytoskeletal contractility to influence spatial positioning and solidify cell fate choice. I will then show that mechanics tunes the response of the cell to biochemical signaling to steer fate choice. This hypothetical feedback loop between mechanics and biochemical signaling likely has significant impact on cellular plasticity both in development and stem cells. I will also present an example demonstrating the functional impact of mechanics on stem cell function. In this example\, we have shown that we can reverse the loss of plasticity associated with ageing by controlling the mechanical microenvironment. Ultimately\, I will advance the hypothesis that mechanical sensing acts as a switch to modulate growth factor signaling to modulate cell fate choice. \n  \nBiography\nKevin Chalut is a biophysicist with a PhD in Physics from Duke University. He is currently a group leader at the Wellcome Trust-Medical Research Council Stem Cell Institute in Cambridge. \nHis work focuses on using the tools and concepts of physics to study cell fate choice in stem cells and developing organisms. His lab primarily investigates how the mechanical microenvironment regulates fate decisions\, and exactly how cells process information during that fate choice. The ultimate goal of his laboratory is to apply their physics-based techniques to understand how organisms develop\, and also how to use stem cells for therapeutic use.
URL:https://mbd.ccrm.ca/event/global-speaker-series-kevin-chalut-june-2019/
LOCATION:Medical Sciences Building\, Room 2172\, 1 King's College Circle\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190603T120000
DTEND;TZID=America/Toronto:20190603T130000
DTSTAMP:20260405T145936
CREATED:20181210T171351Z
LAST-MODIFIED:20200429T165518Z
UID:6162-1559563200-1559566800@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Daniel G. Anderson\, PhD - Massachusetts Institute of Technology
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Daniel G. Anderson\, PhD\, the Samuel A. Goldblith Professor of Applied Biology\, associate professor in the Department of Chemical Engineering and Institute for Medical Engineering and Science\, and a member of the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology. He will give a talk titled\, “Delivery systems for in vivo genome editing and cell therapy.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\nTalk Abstract\nHigh throughput\, combinatorial approaches have revolutionized small molecule drug discovery.  Here we describe our work on the combinatorial development of biomaterials for medical devices ranging from nanoparticulate delivery systems to macroscopic devices.  One focus of our work is on nanoparticulate\, intracellular delivery systems for RNA therapy and gene editing.  Libraries of degradable polymers and lipid-like materials have been synthesized\, formulated and screened for their ability to delivery macromolecular payloads inside of cells.  A number of delivery formulations have been developed with in vivo efficacy\, enabling gene suppression with siRNA\, gene expression with mRNA\, or permanent genetic editing using the CRISPR/Cas9 system.  These formulations show potential therapeutic application for the treatment of disease in both rodent and primate models.  A second focus of our work is on developing biomaterials that can avoid the fibrotic response common to implanted medical devices.  Using combinatorial chemistry\, we have developed new materials capable of avoiding fibrosis and scar tissue formation. These show particular promise as vehicles for the immune-isolation of transplanted cells\, for the treatment of diabetes.  When formulated into microcapsules these materials enable functional\, long-term islet transplantation in immune competent\, diabetic rodents\, as well as normal non-human primates. \nBiography\nLearn more about Daniel G. Anderson
URL:https://mbd.ccrm.ca/event/global-speaker-series-daniel-anderson-june-2019/
LOCATION:Medical Sciences Building\, Room 2172\, 1 King's College Circle\, Toronto\, Ontario\, M5S 1A8\, Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190507T120000
DTEND;TZID=America/Toronto:20190507T130000
DTSTAMP:20260405T145936
CREATED:20181210T170927Z
LAST-MODIFIED:20191126T153836Z
UID:6160-1557230400-1557234000@mbd.ccrm.ca
SUMMARY:Global Speaker Series: Abhay Pandit\, PhD - National University of Ireland Galway
DESCRIPTION:The Medicine by Design Global Speaker Series invites established and emerging international leaders in regenerative medicine to engage with our extraordinary community of researchers and clinicians. \nMedicine by Design\, in partnership with the Ontario Institute for Regenerative Medicine\, is pleased to welcome Abhay Pandit\, PhD\, established professor in biomaterials at the National University of Ireland Galway. He will give a talk titled\, “Redefining Identity of Disease\, Tissues and Cells: A Biomaterials Paradigm.” \n\nDownload event poster\nThis event will be livestreamed (link will be live shortly before event)\n\nLearn more about Abhay Pandit
URL:https://mbd.ccrm.ca/event/global-speaker-series-may-2019/
LOCATION:Canada
CATEGORIES:Global Speaker Series
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
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END:VCALENDAR