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X-WR-CALDESC:Events for Medicine by Design
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BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20201027T120000
DTEND;TZID=America/Toronto:20201027T130000
DTSTAMP:20260406T002925
CREATED:20201026T180617Z
LAST-MODIFIED:20201026T180617Z
UID:10241-1603800000-1603803600@mbd.ccrm.ca
SUMMARY:Adipose Biology Seminar Series
DESCRIPTION:The adipose tissue is an organ widely distributed throughout the body\, and it is involved in a large variety of medical conditions and metabolic disorders. In recent years\, there has been a growing interest in adipose tissue biology research\, both internationally and locally\, in different departments and institutes. This seminar series serves to facilitate discussion and foster collaborations between PIs and trainees with an interest in adipose tissue research in the Toronto region and beyond. The Adipose Biology Seminar Series is an online monthly meeting in which PIs and trainees will present and discuss novel data pertinent to adipose tissue biology. We aim to host speakers from diverse research foci such as obesity\, diabetes\, cancer and trauma to provide an opportunity to learn about exciting new developments in the field and build connections within a local network. If you are interested in showcasing your work and ideas to the adipose research community\, please contact the meeting organizers. \nTo join this group\, please send an email.
URL:https://mbd.ccrm.ca/event/adipose-biology-seminar-series-3/
LOCATION:Virtual
CATEGORIES:Discussion Groups
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20191104T131500
DTEND;TZID=America/Toronto:20191104T141500
DTSTAMP:20260406T002925
CREATED:20190226T211610Z
LAST-MODIFIED:20191125T194315Z
UID:6464-1572873300-1572876900@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Dr. Michael Aregger\, a post-doctoral fellow in the Moffat lab\, will give a talk titled “Global mapping of human genetic interactions using CRISPR-Cas screens.” \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups\n\nTalk Abstract\nCRISPR-Cas technology has revolutionized genome editing and has facilitated the elucidation of gene function and therapeutic targets for diseases such as cancer. During my PostDoc in Jason Moffat’s lab I have developed and applied genome-wide CRISPR-Cas9 screens for the identification of fitness genes in human cells. More recently\, I have applied CRISPR screens for the global mapping of genetic interactions for genes functioning in cellular metabolism\, whose rewiring is a cancer hallmark and a major focus in the development of novel therapeutic agents. Our data reveals extensive cross talk between metabolic pathways and uncovered the functional role of previously uncharacterized genes. Finally\, we have developed a novel CRISPR-Cas screening platform that allows for highly specific combinatorial targeting of multiple genes\, genetic elements or genomic sites. We have applied this platform to reveal extensive genetic interactions between paralogous genes and uncovered previously masked phenotypes due to genetic redundancy. \nCollectively\, in this seminar I will present the CRISPR-based screening strategies we have generated to map genetic interaction networks in human cells that can be leveraged to study the wiring of cellular states\, determine novel gene functions and serve as a source for the rational design of combinatorial anti-cancer therapeutic strategies.
URL:https://mbd.ccrm.ca/event/synbio-discussion-group-2019-november/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190923T133000
DTEND;TZID=America/Toronto:20190923T150000
DTSTAMP:20260406T002925
CREATED:20190912T190234Z
LAST-MODIFIED:20191125T194315Z
UID:6872-1569245400-1569250800@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:This meeting will feature two talks: \n\nJared Te (Dr. Jane Batt lab): “Enabling skeletal muscle repair and functional recovery following denervation-induced injury using ultrasound mediated gene delivery (UMGD)”\nLouise Moyle (Dr. Penney Gilbert lab): “Breaking the LINC in satellite cells: does disrupted mechanosignalling affect skeletal muscle regeneration?”\n\nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Louise Moyle. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-2019-september/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Discussion Groups
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190827T120000
DTEND;TZID=America/Toronto:20190827T130000
DTSTAMP:20260406T002925
CREATED:20190226T210846Z
LAST-MODIFIED:20191125T194315Z
UID:6460-1566907200-1566910800@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Dr. Claudio Monetti\, a senior scientist at panCELLa\, will give a talk. \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/synbio-discussion-group-2019-august/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190826T120000
DTEND;TZID=America/Toronto:20190826T140000
DTSTAMP:20260406T002925
CREATED:20190514T203615Z
LAST-MODIFIED:20191125T194315Z
UID:6622-1566820800-1566828000@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:This group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact the group organizers. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-august-2019/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190730T120000
DTEND;TZID=America/Toronto:20190730T130000
DTSTAMP:20260406T002925
CREATED:20190226T210558Z
LAST-MODIFIED:20191125T194315Z
UID:6458-1564488000-1564491600@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Jenise Chen\, a PhD candidate in the Kelley lab\, will give a talk titled “A multiplexed\, electrochemical interface for cell-free synthetic toehold-mediated gene networks”. \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups\n\nTalk abstract\nThe implementation of colorimetric detection techniques has offered a powerful means of producing rapid qualitative results with easy visual readout. However\, these techniques are usually limited to either a “yes” or “no” answer and have difficulty multiplexing over three targets simultaneously. Electrochemical detection is capable of providing solutions to these limitations. The key advantage of electrochemical assays is the ability for signal amplification\, allowing for trace analyte detection. Recent literature has highlighted the promising avenues of synthetic biology and cell-free gene circuits. This project is the first of its kind to detect cell-free synthetic gene circuits through electrochemical readout. A gold-based electrochemical sensor has been designed to implement five different detection sites for restriction enzyme cutting of surface-immobilized DNA labelled with methylene blue. Restriction enzymes are produced through a cell-free toehold gene circuit and are easily redesigned for disease-specific detection. By coupling electrochemical detection and cell-free toehold gene circuits\, we were able to create a multiplexed assay for applications in antibiotics and antibiotic resistance detection.
URL:https://mbd.ccrm.ca/event/synbio-discussion-group-2019-july/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190729T120000
DTEND;TZID=America/Toronto:20190729T140000
DTSTAMP:20260406T002925
CREATED:20190514T203428Z
LAST-MODIFIED:20191125T194316Z
UID:6620-1564401600-1564408800@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:This group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact the group organizers. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-july-2019/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190624T120000
DTEND;TZID=America/Toronto:20190624T140000
DTSTAMP:20260406T002925
CREATED:20190514T203259Z
LAST-MODIFIED:20191125T194316Z
UID:6618-1561377600-1561384800@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:This group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact the group organizers. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-2/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190528T120000
DTEND;TZID=America/Toronto:20190528T140000
DTSTAMP:20260406T002925
CREATED:20190514T201412Z
LAST-MODIFIED:20191125T194316Z
UID:6614-1559044800-1559052000@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:This meeting will feature two speakers \n\nChristine Nguyen (Stewart lab): “Characterizing the electrophysiological properties of 3D bioengineered skeletal muscle”\nBella Xu (Gilbert lab): “An in vitro functional assay to predict in vivo muscle stem cell engraftment outcomes – faster\, cheaper and easier”\n\nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact the group organizers. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group-may-2019/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190528T120000
DTEND;TZID=America/Toronto:20190528T130000
DTSTAMP:20260406T002925
CREATED:20190226T210212Z
LAST-MODIFIED:20191125T194316Z
UID:6456-1559044800-1559048400@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Michael Garton\, an assistant professor at the Institute of Biomaterials & Biomedical Engineering\, will give a talk titled “Bringing protein interface design to the synthetic biology party”. \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/synbio-discussion-group-2019-may/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190430T120000
DTEND;TZID=America/Toronto:20190430T130000
DTSTAMP:20260406T002925
CREATED:20190226T205829Z
LAST-MODIFIED:20191125T194331Z
UID:6454-1556625600-1556629200@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Lyla El-Fayoumi\, a MSc candidate in the van der Kooy lab\, will give a talk titled “Science at the Speed of Light: Optogenetics 101”. \nLyla El-Fayomi is working with in vivo optogenetic tools to study the neural circuits involved in drug addiction. She will discuss with us the opportunities and challenges presented by optogenetics and introduce her newly-created optogenetics working group that is going to focus on discussing methods and troubleshooting protocols. \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/synbio-discussion-group-2019-april/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190429T120000
DTEND;TZID=America/Toronto:20190429T140000
DTSTAMP:20260406T002925
CREATED:20190426T200220Z
LAST-MODIFIED:20191125T194331Z
UID:6570-1556539200-1556546400@mbd.ccrm.ca
SUMMARY:Myogenesis Discussion Group
DESCRIPTION:This meeting will feature two speakers \n\nEge Sarikaya — “Understanding the disease pathogenesis of X-linked myotubular myopathy”\nLily Huang — “Investigating the role of VMA21in relation to autophagy and myopathy with excessive autophagy (MEA)”\n\nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Louise Moyle. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/myogenesis-discussion-group/
LOCATION:Donnelly Centre for Cellular and Biomolecular Research\, Red Room\, 160 College Street\, Toronto\, Ontario\, M5S 3E1\, Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20190326T120000
DTEND;TZID=America/Toronto:20190326T130000
DTSTAMP:20260406T002925
CREATED:20190226T205147Z
LAST-MODIFIED:20191125T194331Z
UID:6451-1553601600-1553605200@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Leo Chou\, an assistant professor at the Institute of Biomaterials & Biomedical Engineering\, will give a talk titled “What can DNA nanotechnology do for synthetic biology?” \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and receive information about upcoming meetings\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups\n\nTalk Abstract\nThe field of DNA nanotechnology uses nucleic acids as a “brick & mortar” toolset to build synthetic molecular structures and devices. These DNA-based tools leverage the sequence-programmability and predictability of nucleic acid hybridization to enable precise spatiotemporal manipulation of macromolecules as well as higher-ordered assemblies. A central motivation of the field is to be able to design and create artificial molecular assemblies that rival the complexity of natural molecular systems\, and that can perform user-defined tasks across molecular to cellular length scales. The pursuit of this goal also aims to contribute towards a bottom-up understanding of how the spatiotemporal dynamics of biomolecular assemblies dictate their function\, which can inform synthetic biology design. \nIn this talk I will provide an overview of DNA nanotechnology and briefly introduce its fundamental as well as emerging capabilities. I will highlight existing examples of DNA-based molecular tools and devices\, including their use for synthetic biology applications\, such as for controlling receptor signaling and gene expression. I will also highlight efforts from our own group to engineer bio-inspired molecular devices for applications in biological sensing and therapeutic discovery.
URL:https://mbd.ccrm.ca/event/synbio-discussion-group-2019-march/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181211T120000
DTEND;TZID=America/Toronto:20181211T133000
DTSTAMP:20260406T002925
CREATED:20180820T142558Z
LAST-MODIFIED:20191125T194331Z
UID:5658-1544529600-1544535000@mbd.ccrm.ca
SUMMARY:Computational Biology Discussion Group
DESCRIPTION:Professor Rudi Winklbauer from the Department of Cell & Systems Biology will give a talk titled “Adhesion mechanisms for a vast range of cell adhesion strengths.” \nFor more information about topics and speakers and to register\, please contact Maria Abou Chakra or Himanshu Kaul. This group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n Learn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/compbio-discussion-december-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181127T120000
DTEND;TZID=America/Toronto:20181127T133000
DTSTAMP:20260406T002925
CREATED:20180814T221947Z
LAST-MODIFIED:20191125T194331Z
UID:5565-1543320000-1543325400@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Keith Pardee\, an assistant professor at the Leslie Dan Faculty of Pharmacy\, will give a talk on “Cell-free Synthetic Biology:  Rapid\, Low-cost Tools for Human Health.” \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up and received information about upcoming meetings\, please contact Laura Prochazka. \nTalk Abstract\nWe see cell-free technologies as important tools in meeting challenges that face health care systems at home and abroad.  As we have demonstrated\, cell-free hosting of diagnostics and drug manufacturing offers a paradigm shift in how health care systems can adapt rapidly to public health needs\, provide emergency response and extend lab-grade molecular capabilities into virtually any environment.  Such applications are enabled by freeze-dried cell-free (FD-CF) enzymes that are sterile yet retain the properties of cellular transcription and translation for deploying poised molecular components to the field.  \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/synbio-discussion-november-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181113T120000
DTEND;TZID=America/Toronto:20181113T133000
DTSTAMP:20260406T002925
CREATED:20180820T142410Z
LAST-MODIFIED:20191125T194332Z
UID:5656-1542110400-1542115800@mbd.ccrm.ca
SUMMARY:Computational Biology Discussion Group
DESCRIPTION:The Computational Biology Discussion Group will meet. For more information about topics and speakers and to register\, please contact Maria Abou Chakra or Himanshu Kaul. This group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n Learn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/compbio-discussion-november-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181030T120000
DTEND;TZID=America/Toronto:20181030T133000
DTSTAMP:20260406T002925
CREATED:20180814T221116Z
LAST-MODIFIED:20191125T194332Z
UID:5561-1540900800-1540906200@mbd.ccrm.ca
SUMMARY:Computational and Synthetic Biology Discussion Groups
DESCRIPTION:Kaushik Raj\, a PhD candidate in the laboratory of Professor Krishna Mahadevan (Department of Chemical Engineering & Applied Chemistry)\, will give a talk on “Emergent properties in gene regulation”. \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. \nTalk Abstract\nThis talk will focus on how simple motifs in gene regulatory networks come together to result in complex regulatory programs\, and how mathematical models can help us study them. A special emphasis will be given to modelling and engineering bistability in biological systems. \nLearn more about Medicine by Design discussion groups\n\n 
URL:https://mbd.ccrm.ca/event/joint-discussion-october-2018-2/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20181002T120000
DTEND;TZID=America/Toronto:20181002T133000
DTSTAMP:20260406T002925
CREATED:20180820T162328Z
LAST-MODIFIED:20191125T194345Z
UID:5699-1538481600-1538487000@mbd.ccrm.ca
SUMMARY:Computational and Synthetic Biology Discussion Groups
DESCRIPTION:Nicole Mideo\, an assistant professor in the Department of Ecology and Evolutionary Biology\, will give a talk titled “Multiscale models for predicting parasite life history.” \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n Learn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/joint-discussion-october-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180911T120000
DTEND;TZID=America/Toronto:20180911T133000
DTSTAMP:20260406T002925
CREATED:20180809T160748Z
LAST-MODIFIED:20191125T194345Z
UID:5426-1536667200-1536672600@mbd.ccrm.ca
SUMMARY:Computational Biology Discussion Group
DESCRIPTION:The Computational Biology Discussion Group will meet. For more information about topics and speakers and to register\, please contact Maria Abou Chakra or Himanshu Kaul. This group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n Learn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/compbio-discussion-september-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180828T120000
DTEND;TZID=America/Toronto:20180828T133000
DTSTAMP:20260406T002925
CREATED:20180809T143453Z
LAST-MODIFIED:20191125T194345Z
UID:5422-1535457600-1535463000@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group
DESCRIPTION:Christian Euler\, a PhD candidate in the laboratory of Professor Krishna Mahadevan\, will give a talk on “Reverse and Forward Engineering: Modelling Real and Synthetic Systems”.  \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up to get more information on upcoming discussion groups\, please contact Laura Prochazka. \n Learn more about Medicine by Design discussion groups\n\n\nAbstract\nOne of the goals of synthetic biology is to recapitulate the dynamics of known biological systems. Modelling these circuits is essential to both explaining how they work and informing the forward design of novel systems with desired dynamic responses to signal inputs. Beyond this\, new dynamic responses may be possible with the rational\, model-driven repurposing of biological parts. In this tutorial\, the basic steps of dynamic modelling will be presented along with several resources to assist you in further exploring model-based design in your synthetic system. All skill levels are welcome and encouraged to attend. 
URL:https://mbd.ccrm.ca/event/synbio-discussion-august-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180508T120000
DTEND;TZID=America/Toronto:20180508T130000
DTSTAMP:20260406T002925
CREATED:20180320T215232Z
LAST-MODIFIED:20191125T194345Z
UID:5052-1525780800-1525784400@mbd.ccrm.ca
SUMMARY:Computational Discussion Group
DESCRIPTION:The Computational Discussion Group will meet. For more information about topics and speakers and to register\, please contact Maria Abou Chakra or Himanshu Kaul. This group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/computational-discussion-group-may-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180410T120000
DTEND;TZID=America/Toronto:20180410T130000
DTSTAMP:20260406T002925
CREATED:20180320T213951Z
LAST-MODIFIED:20191125T194345Z
UID:5047-1523361600-1523365200@mbd.ccrm.ca
SUMMARY:Computational Discussion Group
DESCRIPTION:The Computational Discussion Group will meet. For more information about topics and speakers and to register\, please contact Maria Abou Chakra or Himanshu Kaul. This group is open to investigators\, trainees and staff affiliated with the University of Toronto. \n\nLearn more about Medicine by Design discussion groups
URL:https://mbd.ccrm.ca/event/computational-discussion-group-2018-april/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=America/Toronto:20180327T120000
DTEND;TZID=America/Toronto:20180327T130000
DTSTAMP:20260406T002925
CREATED:20180320T213720Z
LAST-MODIFIED:20191125T194345Z
UID:5045-1522152000-1522155600@mbd.ccrm.ca
SUMMARY:Synthetic Biology Discussion Group — Trevor McKee\, PhD
DESCRIPTION:Trevor McKee\, PhD\, will speak on “Moving from Images to Data: Resources and expertise in computational pathology at the STTARR core facility.” \nThis group is open to investigators\, trainees and staff affiliated with the University of Toronto. To sign up to get more information on upcoming discussion groups\, please contact Laura Prochazka. \n\nLearn more about Medicine by Design discussion groups\n\nTalk abstract \nA major bottleneck in synthetic biology approaches to medicine is the lack of quantitative data on tissue morphology to inform structural information on pathological and healthy tissue states. Excitingly\, the advent of digital pathology with increasing semi-automated computational analysis workflows is moving the discipline towards a quantitative science. Computational pathology is providing new tools that can both augment a clinical pathologist’s toolbox\, as well as provide new insights into tissue structure at single-cell resolution to guide the development of synthetic biology-guided next-generation therapeutics. Single-cell resolution structural and positional information is also a major part of the Human Cell Atlas\, a worldwide consortium to map every cell and cell lineage in the developing and adult human. We are therefore delighted to gain some insight into the work of Dr. Trevor McKee\, visiting from STTARR to talk to us about “Moving from Images to Data: Resources and expertise in computational pathology at the STTARR core facility.” \nDr. McKee is a biological engineer who received his PhD from MIT under the guidance of Dr. Rakesh K. Jain\, on the application of intravital microscopy to studying barriers to drug and gene delivery in tumours. He runs the Computational Pathology core facility within STTARR\, a multi-modality imaging facility within the Princess Margaret Cancer Centre\, where he leads a team of programmers and technicians to build algorithms to quantitatively measure protein and RNA abundance at the single-cell resolution in whole-slide pathology images\, for academic and pharmaceutical clients. \n 
URL:https://mbd.ccrm.ca/event/synbio-discussion-group-march-2018/
LOCATION:Canada
CATEGORIES:Discussion Groups
ORGANIZER;CN="Medicine by Design":MAILTO:info.mbd@utoronto.ca
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